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Gastrointestinal Immunology, Inflammation, and Inflammatory Diseases

The Gastrointestinal Immunology, Inflammation, and Inflammatory Diseases Program supports basic, clinical, and translational research on mucosal immunology, intestinal immunity, and inflammation in gastrointestinal diseases and conditions.  In particular, the program supports research on differentiation of gut-associated lymphoid tissue, regulation of innate and adaptive immune cell differentiation and function, genetic and epigenetic factors regulating immune responses and inflammation, the role of dietary components and nutrients in mediating inflammatory responses, the mechanisms by which the intestinal microbiota interact with the mucosal immune system to regulate inflammation and contribute to inflammatory diseases, immune response to enteric infections and antigens, and interactions between the immune and epithelial compartments in the gastrointestinal tract.  Translational research is encouraged to translate basic mechanisms regulating inflammation and the pathophysiology of inflammatory diseases into novel targets and therapeutic strategies for treating or preventing disease.  This program also supports clinical research, clinical trials, and epidemiology studies on gastrointestinal inflammatory diseases, including, but not limited to, gluten-sensitive enteropathy, inflammatory bowel disease, and gastritis; malabsorption syndromes; diarrhea; gastric and duodenal ulcers; and disease of the salivary glands (excluding cystic fibrosis).  The program also encourages epidemiology research to address risk factors for disease occurrence and disease prognosis or natural history, and it supports databases and biological repositories that advance clinical and epidemiological studies in digestive diseases and nutrition.
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 NIDDK Staff

 
Jill L. Carrington, Ph.D.Basic Neurogastroenterology; Gastrointestinal Development, Epithelial Biology, Stem Cell Biology, and Inflammation
Frank Hamilton, M.D., M.P.H.Gastrointestinal and Nutrition AIDS; Gastrointestinal Endoscopy Research; Gastrointestinal Mucosa and Immunology; Gastrointestinal Motility
Robert W. Karp, Ph.D.Genetics, Genomics, and Microbiome Studies of the GI Tract, Liver, and Pancreatic Diseases, Nutrition, and ObesityPeter Perrin Ph.D.Gastrointestinal Host-Microbial Interactions, Basic Mucosal Immunology and Inflammation

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
10/9/2014Studies of HIV in Digestive Diseases Limited to Gastrointestinal Mucosal Immunology and Liver Diseases (Summary) RFA-DK-14-019
7/30/2014NIDDK Central Repositories Non-renewable Sample Access (X01) (Summary) PAR-14-301
7/29/2014NIDDK Clinician Scientist Mentoring Award to Promote Workforce Diversity (K05) (Summary) RFA-DK-14-005
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
7/2/2014Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) (Summary) PAR-14-270
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The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.

 

 Research Resources

 
Resource NameDescription
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Predicting Response to Standardized Pediatric Colitis Therapy

The mission of the PROTECT Study is to provide a better understanding of how children newly diagnosed with ulcerative colitis (UC) respond to mesalamine and prednisone (corticosteroid), the standard initial therapies used to treat this disorder…

Intestinal Stem Cell Consortium

The mission of the ISCC is to advance the understanding of intestinal epithelial stem cell biology during development, homeostasis, regeneration and disease. The immediate goals of the ISCC are to isolate, characterize, culture and validate…

Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…

NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of dkNET is to develop a community-based network for…

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 NIDDK Active Trials in Gastrointestinal Diseases

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.