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Gastrointestinal Immunology, Inflammation, and Inflammatory Diseases

The Gastrointestinal Immunology, Inflammation, and Inflammatory Diseases Program supports basic, clinical, and translational research on mucosal immunology, intestinal immunity, and inflammation in gastrointestinal diseases and conditions.  In particular, the program supports research on differentiation of gut-associated lymphoid tissue, regulation of innate and adaptive immune cell differentiation and function, genetic and epigenetic factors regulating immune responses and inflammation, the role of dietary components and nutrients in mediating inflammatory responses, the mechanisms by which the intestinal microbiota interact with the mucosal immune system to regulate inflammation and contribute to inflammatory diseases, immune response to enteric infections and antigens, and interactions between the immune and epithelial compartments in the gastrointestinal tract.  Translational research is encouraged to translate basic mechanisms regulating inflammation and the pathophysiology of inflammatory diseases into novel targets and therapeutic strategies for treating or preventing disease.  This program also supports clinical research, clinical trials, and epidemiology studies on gastrointestinal inflammatory diseases, including, but not limited to, gluten-sensitive enteropathy, inflammatory bowel disease, and gastritis; malabsorption syndromes; diarrhea; gastric and duodenal ulcers; and disease of the salivary glands (excluding cystic fibrosis).  The program also encourages epidemiology research to address risk factors for disease occurrence and disease prognosis or natural history, and it supports databases and biological repositories that advance clinical and epidemiological studies in digestive diseases and nutrition.
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 NIDDK Staff

 
Jill L. Carrington, Ph.D.Basic Neurogastroenterology; Gastrointestinal Development, Epithelial Biology, Stem Cell Biology, and Inflammation
Frank Hamilton, M.D., M.P.H.Gastrointestinal and Nutrition AIDS; Gastrointestinal Endoscopy Research; Gastrointestinal Mucosa and Immunology; Gastrointestinal Motility
Robert W. Karp, Ph.D.Genetics, Genomics, and Microbiome Studies of the GI Tract, Liver, and Pancreatic Diseases, Nutrition, and ObesityPeter PerrinGastrointestinal Host-Microbial Interactions, Basic Mucosal Immunology and Inflammation

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
7/2/2014Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) (Summary) PAR-14-270
7/2/2014NIAID SBIR - Technology Transfer Direct Phase II (SBIR-TT) (R44) - See more at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-14-049.html#sthash.5IEWBI1W.dpuf (Summary) RFA-AI-14-049
6/25/2014NIDDK Mentored Research Scientist Development Award (K01) (Summary) PAR-14-266
6/4/2014Research on Chronic Overlapping Pain Conditions (R01) (Summary) PA-14-244
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​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that … (Summary)

NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  … (Summary)
Gastroparesis Clinical Research Consortium

The GpCRC is focusing on the etiology, natural history, and therapy of gastroparesis. The goal of this consortium is to perform clinical, epidemiological, and therapeutic research in gastroparesis … (Summary)

Intestinal Stem Cell Consortium

The mission of the ISCC is to advance the understanding of intestinal epithelial stem cell biology during development, homeostasis, regeneration and disease. The immediate goals of the ISCC … (Summary)

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 NIDDK Active Trials in Gastrointestinal Diseases

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.