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Hematopoiesis and Hematopoietic Stem Cell Biology

The Hematopoiesis and Hematopoietic Stem Cell Biology program focuses on understanding the basic cellular and molecular mechanisms underlying the production and function of blood cells in health and disease.  Major areas of interest include the basic mechanisms involved in regulating the production and terminal development of blood cells, referred to as hematopoiesis.  Specific areas of interest include: hematopoietic stem cell and progenitor cell phenotypes; regulation of gene expression during hematopoiesis; regulatory molecules and cytokines that influence stem cell and progenitor cell survival, proliferation, and maturation; mechanisms of hematopoietic cell cycle control and lineage commitment; comparative studies of hematopoiesis across species; ontogeny of hematopoietic tissue development; hematopoietic stem cell plasticity in mesenchymal tissue development; hematopoietic stem cells and progenitors as vehicles for gene therapy; and hematopoietic stem cell transplantation and the development of techniques for establishing stable hematopoietic chimeras in order to treat heritable blood diseases.​​​​​​​​​​


 NIDDK Staff

Terry Rogers Bishop, Ph.D.Hematology; Hematology Centers; Hematology Training


 Related Funding Opportunities

Posted DateTitleFull Announcement
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
7/3/2014NIDDK Cooperative Hematology Specialized Core Centers (U54) (Summary) RFA-DK-14-001
7/2/2014Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) (Summary) PAR-14-270
6/25/2014NIDDK Mentored Research Scientist Development Award (K01) (Summary) PAR-14-266
6/4/2014Research on Chronic Overlapping Pain Conditions (R01) (Summary) PA-14-244
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​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.

 Research Resources

Resource NameDescription
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Sirt6 LoxP (Sirt6 tm1.1Cxd) Mouse

Generation of floxed Sirtuin 6 for the construction of conditional knockout mice


The Sirtuins (Sirt1-7), a family of seven proteins related to yeast Sir2, are histone deacetylases … (Summary)

Sirt1 LoxP (Sirt1 tm1Cxd) Mouse

Generation of floxed Sirtuin 1 Exon5-Exon6 for the construction of conditional knockout mice


Sirtuin 1 (Sirt1), a homolog of yeast Sir 2, is an NAD-dependent histone and … (Summary)

Stat5a LoxP/Stat5b LoxP (Stat5a/Stat5b tm2Mam) Mouse

Conditional knockout of Stat5a and Stat5b: Combined deletion of conserved Stat5a and Stat5b in mammary epithelium at different times during pregnancy reveal multiple distinct functions.


The … (Summary)

Tg(MMTV-Cre)#Mam Mouse

Cre-recombinase under the control of mouse mammary tumor virus long terminal repeat (MMTV) was expressed in the salivary gland and mammary epithelial cells of adult mice, and induced recombination … (Summary)

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 NIDDK Active Trials in Hematologic Disease

View related clinical trials from ClinicalTrials.gov.


 Related Study Sections

Study sections conduct initial peer review of applications in a designated scientific area. View related study sections​ from the NIH's Center for Scientific Review.