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Iron and Heme Metabolism, Iron Chelation

The Iron and Heme Metabolism, Iron Chelation program supports work on the regulation of iron absorption, utilization, and storage.  Specific areas of interest include: mechanisms underlying disordered iron utilization and sequestration; genetic determinants of inherited and acquired iron overload disorders; heme synthesis, transport, and metabolism; porphyrias; noninvasive measurement of organ and tissue iron load; and iron chelators and chelation therapy.​​​​​​​

 

 NIDDK Staff

 
Terry Rogers Bishop, Ph.D.Hematology; Hematology Centers; Hematology Training

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
7/18/2014Limited Competition for the Continuation of the Adult Acute Liver Failure Study Group (U01) (Summary) RFA-DK-14-504
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
7/3/2014NIDDK Cooperative Hematology Specialized Core Centers (U54) (Summary) RFA-DK-14-001
7/2/2014Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) (Summary) PAR-14-270
6/25/2014NIDDK Mentored Research Scientist Development Award (K01) (Summary) PAR-14-266
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​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Sirt6 LoxP (Sirt6 tm1.1Cxd) Mouse

Generation of floxed Sirtuin 6 for the construction of conditional knockout mice

 

The Sirtuins (Sirt1-7), a family of seven proteins related to yeast Sir2, are histone deacetylases … (Summary)

Sirt1 LoxP (Sirt1 tm1Cxd) Mouse

Generation of floxed Sirtuin 1 Exon5-Exon6 for the construction of conditional knockout mice

 

Sirtuin 1 (Sirt1), a homolog of yeast Sir 2, is an NAD-dependent histone and … (Summary)

Stat5a LoxP/Stat5b LoxP (Stat5a/Stat5b tm2Mam) Mouse

Conditional knockout of Stat5a and Stat5b: Combined deletion of conserved Stat5a and Stat5b in mammary epithelium at different times during pregnancy reveal multiple distinct functions.

 

The … (Summary)

Tg(MMTV-Cre)#Mam Mouse

Cre-recombinase under the control of mouse mammary tumor virus long terminal repeat (MMTV) was expressed in the salivary gland and mammary epithelial cells of adult mice, and induced recombination … (Summary)

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 NIDDK Active Trials in Hematologic Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 

Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.​