The Kidney Genetics and Genomics program advances research that uses genetics and genomics approaches to understand the normal and pathologic functions of the kidney. Studies seek to elucidate the heritability or molecular genetic basis of single-gene or genetically complex familial diseases in humans. This work includes studies that identify and characterize quantitative trait loci or modifier loci affecting single-gene traits in humans or animal models. The program advances studies of mutagenesis and mutant screens and genotype-phenotype correlations.
The research portfolio also includes work to develop statistical techniques for mapping quantitative trait loci or genes contributing to complex traits, such as haplotype mapping. Program-supported researchers may develop microarray and other high-throughput genomics and proteomics technologies and genomics tools for creation of transgenic or knockout animals. Research includes genomic analysis and genome-anatomy projects.