U.S. Department of Health and Human Services
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Kidney Inflammation and Inflammatory Diseases

The Kidney Inflammation and Inflammatory Diseases program advances research on both normal and pathologic renal processes involving immune- or inflammatory-mediated mechanisms.  Specific projects examine the basic processes that induce kidney cell damage and propagate kidney inflammation.  The program encourages research on these processes in the setting of systemic diseases and primary renal disorders, including chronic allograft nephropathy.  Basic processes of interest include the regulation of renal cell-signaling pathways and cell-surface determinant expression.  Also of interest are studies of cellular matrix protein expression and the regulation of cytokine and growth factor expression in inflammatory renal disease. Researchers investigate the interaction of a number of immune cells—including T and B cell lymphocytes, neutrophils, and macrophages—with renal-specific cell subsets.​​​​​​​​​​

 

 NIDDK Staff

 
Michael Flessner, M.D., Ph.D.Clinical CKD; Glomerular Disease; Clinical PKD; PKD Centers

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
7/2/2014Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) (Summary) PAR-14-270
6/25/2014NIDDK Mentored Research Scientist Development Award (K01) (Summary) PAR-14-266
6/11/2014Chronic Kidney Disease Biomarkers Consortium (CKD BioCon) (U01) (Summary) RFA-DK-14-011
6/10/2014Polycystic Kidney Disease (PKD) Research and Translation Core Centers (P30) (Summary) RFA-DK-14-013
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​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
Rare Kidney Stone Consortium

The Consortium facilitates cooperative exchange of information and resources among investigators, clinicians, patients, and researchers in order to improve care and outcomes for patients with … (Summary)

Randomized Intervention for Children with Vesicoureteral Reflux

The purpose of this study is to learn whether all children with vesicoureteral reflux (VUR) should be treated with antibiotics. The study will tell us if prophylactic antibiotic treatment … (Summary)

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in … (Summary)
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  … (Summary)
United States Renal Data System

The United States Renal Data System (USRDS) is a national data system that collects, analyzes, and distributes information about end-stage renal disease (ESRD) in the United States. The USRDS … (Summary)

View Additional Research Resources

 

 NIDDK Active Trials in Kidney Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.