U.S. Department of Health and Human Services

Liver Diseases Genetics and Genomics

The Liver Diseases Genetics and Genomics program supports research to identify genes that influence normal development, function, and diseases of the liver.  The program supports research to identify genes that influence disease and related anatomical and physiological traits, as well as research on patterns and regulation of gene expression associated with these traits.  Through research involving human subjects as well as model organisms, the program encourages both genome-wide and candidate-gene-based approaches that exploit naturally occurring genetic variation and artificially induced mutations.  Typical research approaches include genetic linkage, association, and linkage-disequilibrium studies; QTL mapping, phenotype- and gene-driven mutagenesis screens; and macro- and microarray-based surveys of gene expression.​​​​​​​​​​​​


 NIDDK Staff

Robert W. Karp, Ph.D.Genetics, Genomics, and Microbiome Studies of the GI Tract, Liver, and Pancreatic Diseases, Nutrition, and Obesity
David SaslowskyCareer Development Programs (K awards)


 Related Funding Opportunities

Posted DateTitleFull Announcement
11/6/2015Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) (Summary) PAR-16-034
11/3/2015Studies of HIV in Digestive Diseases Limited to Gastrointestinal Mucosal Immunology and Liver Diseases (R01) (Summary) RFA-DK-16-016
11/2/2015SBIR/STTR Commercialization Readiness Pilot (CRP) Program: Technical Assistance and Late Stage Development (SB1) (Summary) PAR-16-027
8/7/2015Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Admin Supp) (Summary) PA-15-321
6/29/2015Exploration of the Roles of Brown and Beige Adipose Tissue in Humans (R01) (Summary) RFA-DK-15-031
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction

The EPISOD study is a prospective, double-blind, randomized, sham-controlled, multi-center clinical trial. The EPISOD study enrolls subjects who have received a prior cholecystectomy and are diagnosed with the clinical syndrome of Sphincter of Oddi…

Acute Liver Failure Study Group
The Acute Liver Failure Study Group is collecting biosamples and information on the natural history, causes and outcomes of Acute Liver Failure in the United States. In addition to the database, a clinical trial conducted to test whether the drug…
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of dkNET is to develop a community-based network for…

View Additional Research Resources


 NIDDK Active Trials in Liver Disease

View related clinical trials from ClinicalTrials.gov.


 Related Study Sections

Study sections conduct initial peer review of applications in a designated scientific area. View related study sections​ from the NIH's Center for Scientific Review.

NIH Common Fund

Learn about current projects and view funding opportunities sponsored by the​ ​​NIH Common Fund.​