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Liver Diseases Genetics and Genomics

The Liver Diseases Genetics and Genomics program supports research to identify genes that influence normal development, function, and diseases of the liver.  The program supports research to identify genes that influence disease and related anatomical and physiological traits, as well as research on patterns and regulation of gene expression associated with these traits.  Through research involving human subjects as well as model organisms, the program encourages both genome-wide and candidate-gene-based approaches that exploit naturally occurring genetic variation and artificially induced mutations.  Typical research approaches include genetic linkage, association, and linkage-disequilibrium studies; QTL mapping, phenotype- and gene-driven mutagenesis screens; and macro- and microarray-based surveys of gene expression.​​​​​​​​

 

 NIDDK Staff

 
Robert W. Karp, Ph.D.Genetics, Genomics, and Microbiome Studies of the GI Tract, Liver, and Pancreatic Diseases, Nutrition, and Obesity

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
7/18/2014Limited Competition for the Continuation of the Adult Acute Liver Failure Study Group (U01) (Summary) RFA-DK-14-504
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
7/2/2014Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) (Summary) PAR-14-270
7/2/2014NIAID SBIR - Technology Transfer Direct Phase II (SBIR-TT) (R44) - See more at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-14-049.html#sthash.5IEWBI1W.dpuf (Summary) RFA-AI-14-049
6/25/2014NIDDK Mentored Research Scientist Development Award (K01) (Summary) PAR-14-266
View More Funding Opportunities

​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction

The EPISOD study is a prospective, double-blind, randomized, sham-controlled, multi-center clinical trial. The EPISOD study enrolls subjects who have received a prior cholecystectomy and are … (Summary)

Acute Liver Failure Study Group
The Acute Liver Failure Study Group is collecting biosamples and information on the natural history, causes and outcomes of Acute Liver Failure in the United States. In addition to the database, … (Summary)
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in … (Summary)
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  … (Summary)

View Additional Research Resources

 

 NIDDK Active Trials in Liver Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
Study sections conduct initial peer review of applications in a designated scientific area. View related study sections​ from the NIH's Center for Scientific Review.