U.S. Department of Health and Human Services

Metabolic Pathways

The Metabolic Pathways program supports research on the pathways that are involved in intermediary metabolism as they impact endocrine and metabolic diseases such as diabetes and obesity.  Supported are studies that investigate these pathways from a whole-body perspective as well as within specific tissues (e.g., liver, fat, muscle) and at the cellular and molecular level.  Studies address whole-body fluxes in carbohydrate and lipid metabolism as well as the role of single key molecules or set of molecules in the regulation of these metabolic pathways.  The program promotes research that addresses the development, physiology, and life cycle of fat cells, called adipocytes, and the metabolic role of specific fat depots (e.g., white, beige, brown) throughout the body.  Another area of interest includes the mechanisms involved in protein trafficking, secretion, and processing as they relate to metabolic diseases (e.g., vesicle formation and fusion, unfolded protein response, ER stress).  This program also supports metabolic phenotyping studies that aim to identify, characterize, and validate new animal models of endocrine diseases, obesity, and diabetes and its complications.​​​​​​​​​​​​​​​​​


 NIDDK Staff

Kristin M. Abraham, Ph.D.The role of inflammation in the pathophysiology of metabolic disease and the use of mouse models in metabolic phenotypingCarol Renfrew Haft, Ph.D.Adipocyte development and biology in various fat depots; protein trafficking, secretion, processing and ER stress in metabolic diseaseMaren Laughlin, Ph.D.Integrative metabolism and physiology, and in vivo molecular and functional imaging, as relevant to energy balance in metabolic disease
Aaron Pawlyk, Ph.D.​Key regulators of intermediary metabolism; drug discovery; pharmacogenetics and precision medicine.Karen L. Teff, Ph.D.Effects of bariatric surgery on diabetes and related metabolic outcomes; prevention, treatment and pathophysiology of hypoglycemia; effects of sleep/circadian as well as autonomic nervous system effects on diabetes-related metabolism in humans; clinical and basic research on intermediary hepatic metabolism


 Related Funding Opportunities

Posted DateTitleFull Announcement
11/20/2015Psychosocial and Behavioral Mechanisms in Bariatric Surgery (R01) (Summary) RFA-DK-16-017
11/19/2015Development of New Technologies and Bioengineering Solutions for the Advancement of Cell Replacement Therapies for Type 1 Diabetes (R43/R44) (Summary) RFA-DK-16-004
11/6/2015Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) (Summary) PAR-16-034
11/3/2015Elucidating HIV and HIV-treatment Associated Metabolic/Endocrine Dysfunction (R01) (Summary) RFA-DK-16-014
11/2/2015SBIR/STTR Commercialization Readiness Pilot (CRP) Program: Technical Assistance and Late Stage Development (SB1) (Summary) PAR-16-027
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Efficacy and Mechanisms of Glutamine Dipeptide in the Surgical Intensive Care Unit

The GLND trial is a multi-center, double-blind, placebo-controlled, intent-to-treat Phase III trial, designed to determine the effect of parenteral glutamine (GLN) dipeptide on important clinical outcomes in patients requiring surgical intensive care…

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Lifestyle Interventions for Expectant Moms

LIFE-Moms is a consortium comprised of seven clinical centers, a Research Coordinating Unit and NIH program staff.  The overall goal of the Consortium is to identify effective behavioral and lifestyle interventions that will improve weight, glycemic…

View Additional Research Resources


 NIDDK Active Trials in Metabolic Disease

View related clinical trials from ClinicalTrials.gov.


 Related Study Sections

Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.​

Additional Links


NIH Common Fund

Learn about current projects and view funding opportunities sponsored by the​ ​​NIH Common Fund.​