U.S. Department of Health and Human Services
Staff Search  

If you plan to apply, Register Early.

Registration is required at eRA Commons and grants.gov and can take 4 weeks.​

Metabolic Pathways

The Metabolic Pathways program supports research on the pathways that are involved in intermediary metabolism as they impact endocrine and metabolic diseases such as diabetes and obesity.  Supported are studies that investigate these pathways from a whole-body perspective as well as within specific tissues (e.g., liver, fat, muscle) and at the cellular and molecular level.  Studies address whole-body fluxes in carbohydrate and lipid metabolism as well as the role of single key molecules or set of molecules in the regulation of these metabolic pathways.  The program promotes research that addresses the development, physiology, and life cycle of fat cells, called adipocytes, and the metabolic role of specific fat depots (e.g., white, beige, brown) throughout the body.  Another area of interest includes the mechanisms involved in protein trafficking, secretion, and processing as they relate to metabolic diseases (e.g., vesicle formation and fusion, unfolded protein response, ER stress).  This program also supports metabolic phenotyping studies that aim to identify, characterize, and validate new animal models of endocrine diseases, obesity, and diabetes and its complications.

​​​​​​​​​​
 

 NIDDK Staff

 
Kristin M. Abraham, Ph.D.The role of inflammation in the pathophysiology of metabolic disease and the use of mouse models in metabolic phenotypingCarol Renfrew Haft, Ph.D. Adipocyte development and biology in various fat depots; protein trafficking, secretion, processing and ER stress in metabolic disease
Maren Laughlin, Ph.D.Integrative metabolism and physiology, and in vivo molecular and functional imaging, as relevant to energy balance in metabolic diseaseAaron Pawlyk, Ph.D.Key regulators of intermediary metabolism; drug discovery; pharmacogenetics and personalized medicine in the treatment of diabetes

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) (Summary) PA-14-147
3/7/2014Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31 - Diversity) (Summary) PA-14-148
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) (Summary) PA-14-149
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD or Other Dual-Doctoral Degree Fellowship (Parent F30) (Summary) PA-14-150
1/30/2014Change of Grantee Organization (Type 7 Parent) (Summary) PA-14-078
View More Funding Opportunities

 

 Research Resources

 
Resource NameDescription
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Sirt3 KO (Sirt3 tm1.1Cxd) Mouse

Sirt3 KO: Sirt3 is a mitochondrial-localized tumor suppressor that maintains mitochondrial integrity and metabolism during stress.

 

SirT3 is a mitochondrial protein that is … (Summary)

Sirt1 KO (Sirt1 tm1.1Cxd) Mouse

Sirt1 knockout: Sirt1, a protein deacetylase, is a tumor suppressor that promotes genome stability and regulates proteins involved in energy metabolism.

 

Yeast Sir2, a nicotinamide … (Summary)

M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.

M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.

 

The five Muscarinic Acetylcholine (ACh) receptors … (Summary)

Gs Alpha LoxP (Gnas tm1Lsw) Mouse

Generation of a floxed Gnsa gene for the G-protein Gsα for the construction of conditional knockout mice.

 

The heterotrimeric G protein Gsa couples many receptors to adenylyl … (Summary)

View Additional Research Resources

 

 NIDDK Active Trials in Metabolic Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.​