U.S. Department of Health and Human Services

Motility and Functional Gastrointestinal Disorders

The Motility and Functional Gastrointestinal Disorders program supports basic, clinical, and translational research on aspects of gut physiology regulating motility, including research on the structure of gastrointestinal muscles and the biochemistry of contractile processes and mechano-chemical energy conversion relations between metabolism and contractility in smooth muscle; the basic biology of gut smooth muscle and the role of the nervous system in digestion and factors that affect gut motility; and the effect of gastrointestinal diseases and disorders on gastrointestinal motility.  The program also supports clinical trials to test new treatments for functional gastrointestinal disorders and epidemiology studies to address risk factors for disease occurrence, prognosis, or natural history.  Particular clinical areas of interest include irritable bowel syndrome, gastroparesis, functional dyspepsia, colonic diverticular disease, swallowing disorders, and gastroesophageal reflux.​​​​​​​​​​​​​​​​​​​


 NIDDK Staff

Jill L. Carrington, Ph.D.Basic Neurogastroenterology; Gastrointestinal Development, Epithelial Biology, Stem Cell Biology, and Inflammation
Frank Hamilton, M.D., M.P.H.Gastrointestinal and Nutrition AIDS; Gastrointestinal Endoscopy Research; Gastrointestinal Mucosa and Immunology; Gastrointestinal Motility
David SaslowskyCareer Development Programs (K awards)


 Related Funding Opportunities

Posted DateTitleFull Announcement
8/7/2015Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Admin Supp) (Summary) PA-15-321
7/31/2015Pilot and Feasibility Clinical and Translational Research Studies in Digestive Diseases and Nutrition (R21) (Summary) PA-15-317
7/24/2015Lymphatics in Health and Disease in the Digestive System, Kidney, and Urinary Tract (R01) (Summary) PAR-15-306
6/29/2015Exploration of the Roles of Brown and Beige Adipose Tissue in Humans (R01) (Summary) RFA-DK-15-031
6/24/2015Pre-application: Opportunities for Collaborative Research at the NIH Clinical Center (X02) (Summary) PAR-15-286
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The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Predicting Response to Standardized Pediatric Colitis Therapy

The mission of the PROTECT Study is to provide a better understanding of how children newly diagnosed with ulcerative colitis (UC) respond to mesalamine and prednisone (corticosteroid), the standard initial therapies used to treat this disorder…

Intestinal Stem Cell Consortium

The mission of the ISCC is to advance the understanding of intestinal epithelial stem cell biology during development, homeostasis, regeneration and disease. The immediate goals of the ISCC are to isolate, characterize, culture and validate…

Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…

NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of dkNET is to develop a community-based network for…

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 NIDDK Active Trials in Gastrointestinal Disease

View related clinical trials from ClinicalTrials.gov.


 Related Study Sections

Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.