U.S. Department of Health and Human Services
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Neurobiology of Obesity

The Neurobiology of Obesity program encompasses research on the regulation of body composition by circulating factors.  Specific areas of support comprise the endocrinology of body composition, including interactions between nutrition, exercise, and anabolic hormones; neuropeptides and their receptors involved in regulatory pathways controlling feeding behavior, satiety, and energy expenditure; interactions between the hypothalamic-pituitary-adrenal axis and peripheral metabolic signals (e.g., insulin, leptin, glucocorticoids, ghrelin); the hypothalamic integration of peripheral endocrine and metabolic signals; regulatory networks controlling food intake and energy balance; and the ontogeny of neuronal networks related to obesity.​​​​​​​​​​
 

 NIDDK Staff

 
James Hyde, Ph.D.​Neurobiology of energy balance and body composition in obesity; diabetes centers; career development (“K”) programs
Saul Malozowski, M.D., Ph.D., M.B.A.Neuroendocrinology of hypothalamic-pituitary axis, neuropeptide signaling and receptors; hormonal regulation of bone and mineral metabolism

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
7/30/2014NIDDK Central Repositories Non-renewable Sample Access (X01) (Summary) PAR-14-301
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
7/2/2014NIAID SBIR - Technology Transfer Direct Phase II (SBIR-TT) (R44) - See more at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-14-049.html#sthash.5IEWBI1W.dpuf (Summary) RFA-AI-14-049
6/25/2014NIDDK Mentored Research Scientist Development Award (K01) (Summary) PAR-14-266
6/18/2014Long-Term Outcomes of Bariatric Surgery Using Large Datasets (R01) (Summary) PAR-14-262
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​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that … (Summary)

Diabetes Prevention Program
The DPP showed that lifestyle change or metformin delay the development of type 2 diabetes. The DPPOS is a long-term follow-up study of the DPP participants.
(Summary)
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in … (Summary)
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled … (Summary)

View Additional Research Resources

 

 NIDDK Active Trials in Obesity Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.