U.S. Department of Health and Human Services

Neurobiology of Obesity

The Neurobiology of Obesity program encompasses research on the regulation of body composition by circulating factors.  Specific areas of support comprise the endocrinology of body composition, including interactions between nutrition, exercise, and anabolic hormones; neuropeptides and their receptors involved in regulatory pathways controlling feeding behavior, satiety, and energy expenditure; interactions between the hypothalamic-pituitary-adrenal axis and peripheral metabolic signals (e.g., insulin, leptin, glucocorticoids, ghrelin); the hypothalamic integration of peripheral endocrine and metabolic signals; regulatory networks controlling food intake and energy balance; and the ontogeny of neuronal networks related to obesity.​​​​​​​​​​​​​​


 NIDDK Staff

James F. Hyde, Ph.D.Neurobiology of energy balance and body composition in obesity; Diabetes Research Centers; career development (“K”) programs
Luke E Stoeckel, Ph.D.Cognitive and clinical neuroscience of the non-homeostatic (i.e., extra-hypothalamic) contributions to obesity and diabetes and their complications.


 Related Funding Opportunities

Posted DateTitleFull Announcement
11/20/2015Psychosocial and Behavioral Mechanisms in Bariatric Surgery (R01) (Summary) RFA-DK-16-017
11/6/2015Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) (Summary) PAR-16-034
11/2/2015SBIR/STTR Commercialization Readiness Pilot (CRP) Program: Technical Assistance and Late Stage Development (SB1) (Summary) PAR-16-027
9/17/2015Time-Sensitive Obesity Policy and Program Evaluation (R01) (Summary) PAR-15-346
8/7/2015Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Admin Supp) (Summary) PA-15-321
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Lifestyle Interventions for Expectant Moms

LIFE-Moms is a consortium comprised of seven clinical centers, a Research Coordinating Unit and NIH program staff.  The overall goal of the Consortium is to identify effective behavioral and lifestyle interventions that will improve weight, glycemic…

Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…

View Additional Research Resources


 NIDDK Active Trials in Obesity Disease

View related clinical trials from ClinicalTrials.gov.


 Related Study Sections

​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.

NIH Common Fund

Learn about current projects and view funding opportunities sponsored by the​ ​​NIH Common Fund.​