U.S. Department of Health and Human Services

Nutrition and Obesity Genetics and Genomics

The Nutrition and Obesity Genetics and Genomics program supports research to identify genes that influence human nutrition and nutrient metabolism, obesity, and nutritional disorders.  The program supports research to identify genes that influence anatomical, physiological, and behavioral traits associated with nutrition and obesity, including the genetics of body fat composition and distribution, metabolic rate, energy balance, food consumption and preference, and physical activity levels.  Also of interest is research on patterns and regulation of gene expression associated with these traits.  Through research involving human subjects as well as model organisms, the program encourages both genome-wide and candidate-gene-based approaches that exploit naturally occurring genetic variation and artificially induced mutations.  Typical research approaches include genetic linkage, association, and linkage-disequilibrium studies; QTL mapping, phenotype- and gene-driven mutagenesis screens; and macro- and microarray-based surveys of gene expression.​​​​​a​​​​​​​​


 NIDDK Staff

Robert W. Karp, Ph.D.Genetics, Genomics, and Microbiome Studies of the GI Tract, Liver, and Pancreatic Diseases, Nutrition, and Obesity


 Related Funding Opportunities

Posted DateTitleFull Announcement
5/27/2016Native American Research Centers for Health (NARCH) (S06) (Summary) PAR-16-297
5/26/2016NIH Support for Conferences and Scientific Meetings (Parent R13) (Summary) PA-16-294
5/25/2016Research Supplements to Promote Diversity in Health-Related Research (Admin Supp) (Summary) PA-16-288
5/24/2016Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Admin Supp) (Summary) PA-16-287
5/24/2016Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Admin Supp) (Summary) PA-16-289
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Efficacy and Mechanisms of Glutamine Dipeptide in the Surgical Intensive Care Unit

The GLND trial is a multi-center, double-blind, placebo-controlled, intent-to-treat Phase III trial, designed to determine the effect of parenteral glutamine (GLN) dipeptide on important clinical outcomes in patients requiring surgical intensive care…

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Lifestyle Interventions for Expectant Moms

LIFE-Moms is a consortium comprised of seven clinical centers, a Research Coordinating Unit and NIH program staff.  The overall goal of the Consortium is to identify effective behavioral and lifestyle interventions that will improve weight, glycemic…

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 NIDDK Active Trials in Nutrition and Obesity

View related clinical trials from ClinicalTrials.gov.


 Related Study Sections

Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.