The Nutrition and Obesity Genetics and Genomics program supports research to identify genes that influence human nutrition and nutrient metabolism, obesity, and nutritional disorders. The program supports research to identify genes that influence anatomical, physiological, and behavioral traits associated with nutrition and obesity, including the genetics of body fat composition and distribution, metabolic rate, energy balance, food consumption and preference, and physical activity levels. Also of interest is research on patterns and regulation of gene expression associated with these traits. Through research involving human subjects as well as model organisms, the program encourages both genome-wide and candidate-gene-based approaches that exploit naturally occurring genetic variation and artificially induced mutations. Typical research approaches include genetic linkage, association, and linkage-disequilibrium studies; QTL mapping, phenotype- and gene-driven mutagenesis screens; and macro- and microarray-based surveys of gene expression.