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Nutrition and Obesity Genetics and Genomics

The Nutrition and Obesity Genetics and Genomics program supports research to identify genes that influence human nutrition and nutrient metabolism, obesity, and nutritional disorders.  The program supports research to identify genes that influence anatomical, physiological, and behavioral traits associated with nutrition and obesity, including the genetics of body fat composition and distribution, metabolic rate, energy balance, food consumption and preference, and physical activity levels.  Also of interest is research on patterns and regulation of gene expression associated with these traits.  Through research involving human subjects as well as model organisms, the program encourages both genome-wide and candidate-gene-based approaches that exploit naturally occurring genetic variation and artificially induced mutations.  Typical research approaches include genetic linkage, association, and linkage-disequilibrium studies; QTL mapping, phenotype- and gene-driven mutagenesis screens; and macro- and microarray-based surveys of gene expression.​​​​​a​​​

 

 NIDDK Staff

 
Robert W. Karp, Ph.D.Genetics, Genomics, and Microbiome Studies of the GI Tract, Liver, and Pancreatic Diseases, Nutrition, and Obesity

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
6/25/2014NIDDK Mentored Research Scientist Development Award (K01) (Summary) PAR-14-266
6/18/2014Long-Term Outcomes of Bariatric Surgery Using Large Datasets (R01) (Summary) PAR-14-262
5/19/2014Nutrition Obesity Research Centers (NORCs) (P30) (Summary) RFA-DK-14-002
5/2/2014Administrative Supplements for Research on Dietary Supplements (Admin Supp) (Summary) PAR-14-201
View More Funding Opportunities

​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that … (Summary)

Diabetes Prevention Program
The DPP showed that lifestyle change or metformin delay the development of type 2 diabetes. The DPPOS is a long-term follow-up study of the DPP participants.
(Summary)
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Efficacy and Mechanisms of Glutamine Dipeptide in the Surgical Intensive Care Unit

The GLND trial is a multi-center, double-blind, placebo-controlled, intent-to-treat Phase III trial, designed to determine the effect of parenteral glutamine (GLN) dipeptide on important clinical … (Summary)

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in … (Summary)

View Additional Research Resources

 

 NIDDK Active Trials in Nutrition and Obesity

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.