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Obesity Treatment and Prevention

The Obesity Treatment and Prevention program supports research on the prevention and treatment of overweight and obesity across the lifespan.  Research focuses on critical periods for excess weight gain or high-risk populations.

Prevention research includes studies of treatment approaches to stop the initial development of overweight/obesity or to prevent additional weight or fat gain in those already overweight or obese.  These approaches include behavioral, lifestyle, or environmental interventions to improve diet, decrease sedentary behavior, and increase physical activity.  Treatment research focuses on clinical trials that evaluate different approaches to losing weight, improving BMI percentile in growing children, or maintaining weight loss.  These interventions involve behavioral, pharmacologic, and surgical approaches.

Research to understand and address psychosocial risk factors related to weight management is also supported.  For example, obesity research addressing binge eating, stress, impulsivity, and the influence of social networks might be supported if the primary aim is to improve weight management.

The program also promotes research testing environmental, policy-based, and population-based approaches to the prevention and treatment of obesity, including studies evaluating the impact of programs or policies on diet, physical activity, or obesity development.​​​​​​​​​​​​​​​​​​

 

 NIDDK Staff

 
Dana K. Andersen, M.D.Observational and Investigational Clinical Research; Biomedical Devices, Surgical Interventions, and MedicationsMary Evans, Ph.D.Special Projects in Nutrition, Obesity, and Digestive Diseases; Lifestyle Interventions in Obesity; Nutrition Obesity Research Centers; Diet & Physical Activity Assessment Methodology
Mary Horlick, M.D.Clinical Bariatric Surgery; Pediatric Clinical Obesity Research
Christine Hunter, Ph.D., ABPPBehavioral research on the prevention and treatment of obesity and diabetes; Centers for Diabetes TranslationalRobert Kuczmarski, Dr.P.H.Obesity Prevention and Treatment

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
11/14/2014Administrative Supplements for Research on Sex/Gender Differences (Admin Supp) (Summary) PA-15-034
10/28/2014Food Specific Molecular Profiles and Biomarkers of Food and Nutrient Intake, and Dietary Exposure (R01) (Summary) PAR-15-024
9/24/2014Psychosocial and Behavioral Aspects of Bariatric Surgery (R01) (Summary) RFA-DK-14-026
8/25/2014Identification of Novel Targets and Pathways Mediating Weight Loss, Diabetes Resolution and Related Metabolic Disease after Bariatric Surgery in Humans (R01) (Summary) RFA-DK-14-025
8/14/2014Understanding Factors in Infancy and Early Childhood (Birth to 24 months) That Influence Obesity Development (R01) (Summary) PAR-14-323
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The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.

 

 Research Resources

 
Resource NameDescription
Efficacy and Mechanisms of Glutamine Dipeptide in the Surgical Intensive Care Unit

The GLND trial is a multi-center, double-blind, placebo-controlled, intent-to-treat Phase III trial, designed to determine the effect of parenteral glutamine (GLN) dipeptide on important clinical outcomes in patients requiring surgical intensive care…

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Lifestyle Interventions for Expectant Moms

LIFE-Moms is a consortium comprised of seven clinical centers, a Research Coordinating Unit and NIH program staff.  The overall goal of the Consortium is to identify effective behavioral and lifestyle interventions that will improve weight, glycemic…

View Additional Research Resources

 

 NIDDK Active Trials in Obesity and Nutrition

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.