U.S. Department of Health and Human Services

Pathophysiology of Diabetes and Metabolic Disease

The Pathophysiology of Diabetes and Metabolic Disease Program supports basic and clinical research that addresses the pathophysiology of metabolic diseases, including type 1 and type 2 diabetes. This Program also includes studies that address the etiology of type 1 diabetes and other autoimmune endocrine diseases, such as autoimmune thyroid disease.

This Program supports both basic mechanistic and clinical studies that address the effect of the intrauterine environment on subsequent metabolic disease in the offspring, as well as the role of gestational diabetes on the subsequent development of maternal diabetes. Also included are studies that use innovative technologies, such as genetic and epigenetic analyses, systems biology, and bioengineering, to understand the biological networks of underlying disease, with the goal of developing novel therapeutic strategies.​​​


 NIDDK Staff

Kristin M. Abraham, Ph.D.The role of inflammation in the pathophysiology of metabolic disease and the use of mouse models in metabolic phenotypingOlivier Blondel, Ph.D.Pathophysiology of the endocrine pancreas in diabetes; technology development (i.e. genomics and systems biology) in metabolic diseaseAndrew Bremer, M.D., Ph.D.Basic science and clinical research focused on the prevention and treatment of type 2 diabetes; diet and exercise in the prevention and management of type 2 diabetes; gestational diabetes and maternal outcomes; and HIV and HIV-treatment associated metabolic/endocrine dysfunctionBarbara Linder, M.D., Ph.D.Type 2 diabetes in children and youth; medical management of type 1 diabetes in youth and adults; human studies of the effect of the intrauterine environment on subsequent development of metabolic disease in offspring.
Corinne M. Silva, Ph.D.Signaling pathways and nutrient sensing in metabolic tissues; mechanisms involved in the role of intrauterine environment in offspring metabolic diseaseLisa M. Spain, Ph.D.Etiology and pathogenesis of type 1 diabetes and other autoimmune endocrine diseasesKaren L. Teff, Ph.D.Effects of bariatric surgery on diabetes and related metabolic outcomes; prevention, treatment and pathophysiology of hypoglycemia; effects of sleep/circadian as well as autonomic nervous system effects on diabetes-related metabolism in humans; clinical and basic research on intermediary hepatic metabolism


 Related Funding Opportunities

Posted DateTitleFull Announcement
11/19/2015Development of New Technologies and Bioengineering Solutions for the Advancement of Cell Replacement Therapies for Type 1 Diabetes (R43/R44) (Summary) RFA-DK-16-004
11/6/2015Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) (Summary) PAR-16-034
11/3/2015Elucidating HIV and HIV-treatment Associated Metabolic/Endocrine Dysfunction (R01) (Summary) RFA-DK-16-014
11/2/2015SBIR/STTR Commercialization Readiness Pilot (CRP) Program: Technical Assistance and Late Stage Development (SB1) (Summary) PAR-16-027
10/8/2015Research Using Biosamples and Subjects from Type 1 Diabetes Clinical Studies Complications (DP3) (Summary) RFA-DK-15-019
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is to facilitate translation from the lab to the clinic of…
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…

View Additional Research Resources


 NIDDK Active Trials in Diabetes and Metabolic Disease

View related clinical trials from ClinicalTrials.gov.


 Related Study Sections

Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.​

NIH Common Fund

Learn about current projects and view funding opportunities sponsored by the​ ​​NIH Common Fund.​