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Pathophysiology of Diabetes and Metabolic Disease

The Pathophysiology of Diabetes and Metabolic Disease Program supports basic and clinical research that addresses the pathophysiology of metabolic diseases, including type 1 and type 2 diabetes. This Program includes studies that address the etiology of type 1 diabetes and other autoimmune endocrine diseases, such as AITD-autoimmune thyroid disease. Also included is research to investigate the role of pro- or anti- inflammatory pathways in the development and progression of diabetes and metabolic diseases such as obesity.

This Program supports both basic mechanistic and clinical studies that address the effect of the intrauterine environment on subsequent metabolic disease in the offspring, as well as the role of gestational diabetes on the subsequent development of maternal diabetes. Also included are studies that use innovative technologies, such as genetic and epigenetic analyses, systems biology, and bioengineering, to understand the biological networks of underlying disease, with the goal of developing novel therapeutic strategies.​​​​​​​​​​​​​​​​​

 

 NIDDK Staff

 
Kristin M. Abraham, Ph.D.The role of inflammation in the pathophysiology of metabolic disease and the use of mouse models in metabolic phenotypingOlivier Blondel, Ph.D.Pathophysiology of the endocrine pancreas in diabetes; technology development (i.e. genomics and systems biology) in metabolic diseaseAndrew BremerBasic science and clinical research focused on the prevention and treatment of type 2 diabetes; diet and exercise in the prevention and treatment of type 2 diabetesBarbara Linder, M.D., Ph.D.Type 2 diabetes in children and youth; glycemic reduction approaches and hypoglycemia during pregnancy; metabolic imprinting
Corinne M. Silva, Ph.D.Signaling pathways and nutrient sensing in metabolic tissues; mechanisms involved in the role of intrauterine environment in offspring metabolic diseaseLisa M. Spain, Ph.D.Etiology and pathogenesis of type 1 diabetes and other autoimmune endocrine diseasesKaren L. Teff, Ph.D.Prevention, treatment and pathophysiology of hypoglycemia; gestational diabetes; and the effects of bariatric surgery on diabetes and related outcomes

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
7/30/2014NIDDK Central Repositories Non-renewable Sample Access (X01) (Summary) PAR-14-301
7/21/2014Advanced Clinical Trials to test Artificial Pancreas Device Systems in Type 1 Diabetes (UC4) (Summary) RFA-DK-14-024
7/17/2014High Throughput Screening (HTS) to Discover Chemical Probes (R01) (Summary) PAR-14-284
7/2/2014Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) (Summary) PAR-14-270
7/2/2014NIAID SBIR - Technology Transfer Direct Phase II (SBIR-TT) (R44) - See more at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-14-049.html#sthash.5IEWBI1W.dpuf (Summary) RFA-AI-14-049
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​The resources listed below include reagents, data, protocols, etc.  If you would like to utilize any of these resources, contact the person associated with the resource.
 

 Research Resources

 
Resource NameDescription
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is … (Summary)
Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that … (Summary)

Diabetes Prevention Program
The DPP showed that lifestyle change or metformin delay the development of type 2 diabetes. The DPPOS is a long-term follow-up study of the DPP participants.
(Summary)
Diabetes Prevention Program Outcomes Study
The Diabetes Prevention Program Outcomes Study is studying the long term effect of diet and exercise and the diabetes medication, metformin, on the delay of type 2 diabetes in participants of … (Summary)
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

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 NIDDK Active Trials in Diabetes and Metabolic Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.​