The Pathophysiology of Diabetes and Metabolic Disease Program supports basic and clinical research that addresses the pathophysiology of metabolic diseases, including type 1 and type 2 diabetes. This Program includes studies that address the etiology of type 1 diabetes and other autoimmune endocrine diseases, such as AITD-autoimmune thyroid disease. Also included is research to investigate the role of pro- or anti- inflammatory pathways in the development and progression of diabetes and metabolic diseases such as obesity.
This Program supports both basic mechanistic and clinical studies that address the effect of the intrauterine environment on subsequent metabolic disease in the offspring, as well as the role of gestational diabetes on the subsequent development of maternal diabetes. Also included are studies that use innovative technologies, such as genetic and epigenetic analyses, systems biology, and bioengineering, to understand the biological networks of underlying disease, with the goal of developing novel therapeutic strategies.