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Obesity, Pregnancy, and the Intrauterine Environment

The Obesity, Pregnancy, and Intrauterine Environment program supports basic and clinical research to understand the impact of metabolic dysfunction on the intrauterine environment and subsequent metabolic health of both mother and offspring.  The program supports observational and interventional clinical studies on the adverse effects of obesity and gestational/type 2 diabetes during pregnancy on mothers and their offspring.  Interventional studies may involve, but are not limited to, diet (including food components/dietary supplements), physical activity programs, medications, or bariatric surgery that aim to mitigate or prevent adverse effects of over-nutrition during and after pregnancy/delivery in both the mothers and their offspring.  The program also supports basic and clinical research investigating the mechanisms by which the intrauterine environment alters metabolic responses in offspring.  A particular focus is on the role of the pathophysiological consequences of obesity and/or diabetes on the offspring.  The long-term goal of this program is to identify molecular targets that could be therapeutically altered in order to prevent or ameliorate the increasing incidence and deleterious effects of obesity and type 2 diabetes.​​​​​​
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 NIDDK Staff

 
Mary Evans, Ph.D.Special Projects in Nutrition, Obesity, and Digestive Diseases; Lifestyle Interventions in Obesity; Nutrition Obesity Research CentersMary Horlick, M.D.Clinical Bariatric Surgery; Pediatric Clinical Obesity ResearchBarbara Linder, M.D., Ph.D.Type 2 diabetes in children and youth; glycemic reduction approaches and hypoglycemia during pregnancy; metabolic imprinting
Corinne M. Silva, Ph.D.Signaling pathways and nutrient sensing in metabolic tissues; mechanisms involved in the role of intrauterine environment in offspring metabolic diseaseKaren L. Teff, Ph.D.Prevention, treatment and pathophysiology of hypoglycemia; gestational diabetes; and the effects of bariatric surgery on diabetes and related outcomes

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) (Summary) PA-14-147
3/7/2014Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31 - Diversity) (Summary) PA-14-148
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) (Summary) PA-14-149
3/7/2014Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD or Other Dual-Doctoral Degree Fellowship (Parent F30) (Summary) PA-14-150
2/24/2014Behavioral Interventions to Address Multiple Chronic Health Conditions in Primary Care (R01) (Summary) PA-14-114
View More Funding Opportunities

 

 Research Resources

 
Resource NameDescription
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of … (Summary)

Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that … (Summary)

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in … (Summary)
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled … (Summary)
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  … (Summary)

View Additional Research Resources

 

 NIDDK Active Trials in Pregnancy Health

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.