U.S. Department of Health and Human Services

Obesity, Pregnancy, and the Intrauterine Environment

The Obesity, Pregnancy, and Intrauterine Environment program supports basic and clinical research to understand the impact of metabolic dysfunction on the intrauterine environment and subsequent metabolic health of both mother and offspring. The program supports observational and interventional clinical studies on the adverse effects of obesity and gestational/type 2 diabetes during pregnancy on mothers and their offspring. Interventional studies may involve, but are not limited to, diet (including food components/dietary supplements), physical activity programs, medications, or bariatric surgery that aim to mitigate or prevent adverse effects of over-nutrition during and after pregnancy/delivery in both the mothers and their offspring. The program also supports basic and clinical research investigating the mechanisms by which the intrauterine environment alters metabolic responses in offspring. A particular focus is on the role of the pathophysiological consequences of obesity and/or diabetes on the offspring. The long-term goal of this program is to identify molecular targets that could be therapeutically altered in order to prevent or ameliorate the increasing incidence and deleterious effects of obesity and type 2 diabetes.​​​​​​​​​​

 

 NIDDK Staff

 
Andrew Bremer, M.D., Ph.D.Clinical studies related to type 1 and 2 diabetes; gestational diabetes and maternal outcomes; HIV-associated metabolic/endocrine dysfunctionMary Evans, Ph.D.Multi-center Clinical Studies in Nutrition & Obesity; Nutrition Obesity Research Centers; Diet & Physical Activity Assessment Methodology
Barbara Linder, M.D., Ph.D.Type 2 diabetes in children and youth; medical management of type 1 diabetes in children, youth and adults; human studies of metabolic imprintingCorinne M. Silva, Ph.D.Signaling pathways, nuclear receptors and nutrient sensing in metabolic tissues; role of intrauterine environment in offspring metabolic disease

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
5/10/2016BD2K Predoctoral Training in Biomedical Big Data Science (T32) (Summary) RFA-LM-16-002
5/4/2016BD2K Mentored Career Development Award in Biomedical Big Data Science for Clinicians and Doctorally Prepared Scientists (K01) (Summary) RFA-ES-16-002
5/4/2016BD2K Mentored Career Development Award in Biomedical Big Data Science for Intramural Investigators (K22) (Summary) RFA-ES-16-003
4/27/2016Nutrition Obesity Research Centers (NORCs) (P30) (Summary) RFA-DK-16-006
4/21/2016NIDDK Mentored Research Scientist Development Award (K01) (Summary) PAR-16-211
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The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.

 

 Research Resources

 
Resource NameDescription
Integrated Islet Distribution Program

The goal of the Integrated Islet Distribution Program (IIDP) is to work with the leading islet isolation centers in the U.S. to distribute high quality human islets to the diabetes research community, in order to advance scientific discoveries and…

Efficacy and Mechanisms of Glutamine Dipeptide in the Surgical Intensive Care Unit

The GLND trial is a multi-center, double-blind, placebo-controlled, intent-to-treat Phase III trial, designed to determine the effect of parenteral glutamine (GLN) dipeptide on important clinical outcomes in patients requiring surgical intensive care…

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…

View Additional Research Resources

 

 NIDDK Active Trials in Pregnancy Health

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.