|Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction
The EPISOD study is a prospective, double-blind, randomized, sham-controlled, multi-center clinical trial. The EPISOD study enrolls subjects who have received a prior cholecystectomy and are diagnosed with the clinical syndrome of Sphincter of Oddi…
|Efficacy and Mechanisms of Glutamine Dipeptide in the Surgical Intensive Care Unit
The GLND trial is a multi-center, double-blind, placebo-controlled, intent-to-treat Phase III trial, designed to determine the effect of parenteral glutamine (GLN) dipeptide on important clinical outcomes in patients requiring surgical intensive care…
|Acute Liver Failure Study Group
The Acute Liver Failure Study Group is collecting biosamples and information on the natural history, causes and outcomes of Acute Liver Failure in the United States. In addition to the database, a clinical trial conducted to test whether the drug…
|Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial. Treatment in ACCORD ended in 2009 and…
|Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
|Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research. Toward this goal, DiaComp: (1) sponsors annual meetings in…
|Predicting Response to Standardized Pediatric Colitis Therapy
The mission of the PROTECT Study is to provide a better understanding of how children newly diagnosed with ulcerative colitis (UC) respond to mesalamine and prednisone (corticosteroid), the standard initial therapies used to treat this disorder…
|Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network
To help better understand the underlying causes of the two most prominent chronic urological pain syndromes—interstitial cystitis/painful bladder syndrome (IC/PBS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)—the National Institute…
|Intestinal Stem Cell Consortium
The mission of the ISCC is to advance the understanding of intestinal epithelial stem cell biology during development, homeostasis, regeneration and disease. The immediate goals of the ISCC are to isolate, characterize, culture and validate…
|Lifestyle Interventions for Expectant Moms
LIFE-Moms is a consortium comprised of seven clinical centers, a Research Coordinating Unit and NIH program staff. The overall goal of the Consortium is to identify effective behavioral and lifestyle interventions that will improve weight, glycemic…
(Mutant Mouse: Transgene expresess the tetracycline-inhibitable transcription factor driven by the mouse major urinary protein promoter)
Tetracycline-responsive transcriptional activator driven by the liver-specific mouse major urinary protein promoter (MUP-tTA).
The E. Coli tetracycline operon regulatory system was used to generate a liver-specific transcription activation system that…
|Alb-tTA (Tg(Alb1-tTA)3123Lng) Mouse
(Mutant Mouse: Transgene expresess the tetracycline-inhibitable transcription factor driven by the mouse albumin promoter)
Tetracycline-responsive transcriptional activator driven by the liver-specific mouse albumin promoter (Alb-tTA).
The E. Coli tetracycline operon regulatory system was used to generate a liver-specific transcription activation system that was inhibited…
|Gs Alpha LoxP (Gnas tm1Lsw) Mouse
(Mutant Mouse: GNAS (guanine nucleotide binding protein, alpha stimulating))
Generation of a floxed Gnsa gene for the G-protein Gsα for the construction of conditional knockout mice.
The heterotrimeric G protein Gsa couples many receptors to adenylyl cyclase and is essential for hormone-stimulated cAMP generation. Previous…
|UTX LoxP Mouse
(Mutant Mouse: Kdm6a (lysine (K)-specific demethylase 6A))
UTX-flox. Conditional knockout mice for the histone demethylase UTX (Kdm6a) conditional knockout will help understand its role as a tumor suppressor.
Di- and tri-methylations on histone H3 lysine 27 (H3K27me2 and H3K27me3) are epigenetic marks for…
(Mutant Mouse: MMTV-Cre (Mammary tumor virus long terminal repeat-Cre recombinase))
Cre-recombinase under the control of mouse mammary tumor virus long terminal repeat (MMTV) was expressed in the salivary gland and mammary epithelial cells of adult mice, and induced recombination in all tissues.
The Cre recombinase from bacteriophage…
(Mutant Mouse: WAP-Cre (whey acidic protein promoter directs Cre recombinase))
Cre-recombinase under the control of the whey acidic acid protein was only detected in alveolar epithelial epithelial cells of mammary tissue during lactation, and transcription occurred at all stages of mammary development.
The Cre recombinase from…
|Stat5a LoxP/Stat5b LoxP (Stat5a/Stat5b tm2Mam) Mouse
(Mutant Mouse: Stat5a/b)
Conditional knockout of Stat5a and Stat5b: Combined deletion of conserved Stat5a and Stat5b in mammary epithelium at different times during pregnancy reveal multiple distinct functions.
The signal transducer and activator of transcription (STAT…
|Stat5a KO(Stat5a tm1Mam) Mouse
(Mutant Mouse: Stat 5a (Signal transducer and activator of transcription))
Stat 5a Knockout: Stat5a deficiency results in the loss of prolactin-dependent mammary gland development and lactogenesis.
Prolactin induces mammary gland development and lactogenesis. Binding of Prolactin to its receptor leads to the phosphorylation…
|Stat1LoxP (Stat1 tm1Mam) Mouse
(Mutant Mouse: Stat1)
Selective inactivation of Stat 1 in mammary cells indicates that its effect as a tumor suppressor in breast is direct.
STAT1 is considered a tumor suppressor, but it is not known if this effect occurs directly in mammary cells or secondarily by…
|Sphk1 KO Mouse
(Mutant Mouse: Sphk1 (Sphingosine kinase 1))
A Sphingosine kinase 1 (Sphk1) knockout mouse.
Sphingosine kinase 1 and 2 are enzymes that produce sphingosine-1-phosphate (S1P), a potent bioactive compound that activates a family of G-protein coupled receptors known as S1P receptors. Triggering…
|MRI imaging algorithm (U.S. Patent Number 61/692,191)|
Atherosclerosis is the underlying cause of coronary artery disease, the number one cause of death in the United States. It is a slowly progressing chronic disease in which cholesterol deposition, invasion of monocytes and smooth muscle cells, and…
|Antimicrobial Compounds that Inhibit FTSZ Protein (U.S. Patent Number 61/446,978)|
This invention, offered for licensing and commercial development, relates to a new class of naturally occurring antimicrobial compounds called Chrysophaetins, and to their synthetic analogues. Isolated from an alga species, the mechanism of action of…
|Personalized Body Weight Management System Using Monitoring Devices and Mathematical Models of Metabolism|
Attempts to manage body weight are often unsuccessful or only temporary. This is, in part, due to antiquated dieting methods that attempt to address calorie consumption while ignoring metabolic and physical changes. It is becoming clear that…
|Sphk2 KO Mouse
(Mutant Mouse: Sphk2 (Sphingosine Kinase 2))
A knockout mouse for Sphingosine kinase 2 (Sphk2).
Sphingosine kinase 1 and 2 are enzymes that produce sphingosine-1-phosphate (S1P), a potent bioactive compound that activates a family of G-protein coupled receptors known as S1P receptors…
|Podocin-rtTA (Tg(NPHS2-rtTA2*M2)1Jbk Mouse
(Mutant Mouse: The tet transactivator (rtTA) gene placed under the control of the human NPHS2 gene).)
Reverse tetracycline-controlled transgenic mouse model (Tet-On) under the control of the specific promoter for the glomerular podocyte protein (Podocin, NPHS2).
Podocytes are post-mitotic epithelial cells that are positioned on the exterior aspect of…
|mEpoR KO / Tg(hEpoR) Mouse
(Mutant Mouse: human erythropoietin receptor transgene bred onto a mouse erythropoietin receptor null background)
mEpoR-/- hEpoR+: The mouse Erythropoietin Receptor knockout that contains a human Erythropoietin Receptor transgene can be used to define the potency of recombinant erythropoietin preparations used to treat anemia associated with chronic kidney…
|M5 Muscarinic receptor KO (Chrm5 tm1Jwe) Mouse
(Mutant Mouse: Chrm5)
M5 Muscarinic Receptor Knockout: Deficiency of M5Rs reduces drug-seeking behavior.
The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively…
|M4 Muscarinic receptor KO (Chrm4 tm1Jwe) Mouse
(Mutant Mouse: Chrm4)
M4 Muscarinic Receptor Knockout: Activation of M4R may reduce the reinforcing effect of drugs of abuse, and contribute to the analgesic effects observed after administration of muscarinic agonists.
The five Muscarinic Acetylcholine (ACh) receptors are…
|M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.
(Mutant Mouse: M3 Muscarinic receptor KO (Chrm3 tm1Jwe) Mouse)
M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.
The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to…
|M1 Muscarinic receptor KO (Chrm1 tm1Jwe) Mouse
(Mutant Mouse: Chrm1 (Cholinergic Receptor, muscarinic 1))
M1 Muscarinic Receptor Knockout: support involvement in cognitive processes.
The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively couple to…