|Acute Liver Failure Study Group
The Acute Liver Failure Study Group is collecting biosamples and information on the natural history, causes and outcomes of Acute Liver Failure in the United States. In addition to the database, a clinical trial conducted to test whether the drug…
|Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction
The EPISOD study is a prospective, double-blind, randomized, sham-controlled, multi-center clinical trial. The EPISOD study enrolls subjects who have received a prior cholecystectomy and are diagnosed with the clinical syndrome of Sphincter of Oddi…
|Integrated Islet Distribution Program
The goal of the Integrated Islet Distribution Program (IIDP) is to work with the leading islet isolation centers in the U.S. to distribute high quality human islets to the diabetes research community, in order to advance scientific discoveries and…
|MEN1, the gene associated with multiple endocrine neoplasia type 1, menin polypeptides and uses thereof (U.S. Patent Number 7,358,347)|
The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated…
|Use of homo sapiens chromosome 1 open reading frame 28 (c1orf28) in the diagnosis of hyperparathyroidism-jaw tumor syndrome (U.S. Patent Application Number WO 2003094860 A3)|
The present invention provides an isolated or purified oligonucleotide consisting essentially of the nucleotide sequence of Clorf28 and comprising a mutation; a fragment of the oligonucleotide; a vector comprising the oligonucleotide or fragment…
|Anti-HIV Acylthiol & Thioether prodrugs (U.S. Patent Number 12/414,321)|
These inventions provide the compositions, pharmaceutical carrier, and usages of the new Acylthiols (E-329-2000 family) and Thioether pro-drug (E-177-2010 family) compounds in treatment of retroviral infections such as HIV. These compounds target the…
|Programmable self-assembled nanostructures based on sidechain-modified pna for the multivalent display of ligands (U.S. Patent Number EP 2569328 A2)|
The invention concerns compositions comprising strands of polynucleotide and strands of PNA, each PNA strand comprising:
- (i) from 2 to 50 nucleobase subunits and
- (ii) one or more gamma substituents.
The PNA strands are complementary to at least a…
|A3 Adenosine Receptor Antagonists (U.S. Patent Number 6,376,521)|
This invention relates to a method of decreasing intraocular pressure by administrating an A3 subtype adenosine receptor antagonist, a calmodulin antagonist or an antiestrogen such as tamoxifen.
|Epibatidine and derivatives, compositions and methods of treating pain (Patent Number U.S. 5,314,899)|
The present invention is directed to compounds, compositions and methods of treating pain, and derivatives that have potent analgetic activity. The compounds have the formula: ##STR1## wherein R.sup.1 is selected from H, lower alkyl, C.sub.3 -C.sub.9…
|Nicotinic acetylcholine receptor agonists (U.S. Patent Application Number WO 2011116282 A3)|
The invention provides novel nicotinic acetylcholine receptor agonists, for example, phaiitasmidine and derivatives thereof, for example a compound of formula (I). Also disclosed are methods of treating disorders responsive to nicotinic acetylcholine…
|PNA-Detection of Pathogens (U.S. Patent Number 13/592,490)|
The laboratory of Daniel Appella, PhD. has developed a prototype HIV testing kit that employs a peptide nucleic acid probe to capture HIV RNA recovered from patient blood. The probe targets a highly conserved segment of the Gag sequence. Initial…
|Efficacy and Mechanisms of Glutamine Dipeptide in the Surgical Intensive Care Unit
The GLND trial is a multi-center, double-blind, placebo-controlled, intent-to-treat Phase III trial, designed to determine the effect of parenteral glutamine (GLN) dipeptide on important clinical outcomes in patients requiring surgical intensive care…
|Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial. Treatment in ACCORD ended in 2009 and…
|Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
|Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research. Toward this goal, DiaComp: (1) sponsors annual meetings in…
|Predicting Response to Standardized Pediatric Colitis Therapy
The mission of the PROTECT Study is to provide a better understanding of how children newly diagnosed with ulcerative colitis (UC) respond to mesalamine and prednisone (corticosteroid), the standard initial therapies used to treat this disorder…
|Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network
To help better understand the underlying causes of the two most prominent chronic urological pain syndromes—interstitial cystitis/painful bladder syndrome (IC/PBS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)—the National Institute…
|Intestinal Stem Cell Consortium
The mission of the ISCC is to advance the understanding of intestinal epithelial stem cell biology during development, homeostasis, regeneration and disease. The immediate goals of the ISCC are to isolate, characterize, culture and validate…
|Lifestyle Interventions for Expectant Moms
LIFE-Moms is a consortium comprised of seven clinical centers, a Research Coordinating Unit and NIH program staff. The overall goal of the Consortium is to identify effective behavioral and lifestyle interventions that will improve weight, glycemic…
|Pituitary TRH receptor (U.S. Patent Number 5,288,621)|
Disclosed for the first time is the isolation, sequence, and expression cloning of a cDNA encoding for pituitary thyrotropin-releasing hormone receptor, as well as the amino acid sequence for the receptor per se.
|Receptors that regulate cell signaling relating to chemokines (U.S. Patent Number 6,365,356)|
A method for discovering molecules that regulate cell signaling specific to the dual presence of Duffy antigen receptor for chemokines (DARC) and a chemokine receptor selected from the group consisting of a CXC receptor, a CC receptor and a CXXXC…
Hembase is an integrated browser and genome portal designed for web-based examination of the human erythroid transcriptome. To date, Hembase contains 15,752 entries from erythroblast Expressed Sequenced Tags (ESTs) and 380 referenced genes relevant…
(Mutant Mouse: Transgene expresess the tetracycline-inhibitable transcription factor driven by the mouse major urinary protein promoter)
Tetracycline-responsive transcriptional activator driven by the liver-specific mouse major urinary protein promoter (MUP-tTA).
The E. Coli tetracycline operon regulatory system was used to generate a liver-specific transcription activation system that…
|Alb-tTA (Tg(Alb1-tTA)3123Lng) Mouse
(Mutant Mouse: Transgene expresess the tetracycline-inhibitable transcription factor driven by the mouse albumin promoter)
Tetracycline-responsive transcriptional activator driven by the liver-specific mouse albumin promoter (Alb-tTA).
The E. Coli tetracycline operon regulatory system was used to generate a liver-specific transcription activation system that was inhibited…
|Gs Alpha LoxP (Gnas tm1Lsw) Mouse
(Mutant Mouse: GNAS (guanine nucleotide binding protein, alpha stimulating))
Generation of a floxed Gnsa gene for the G-protein Gsα for the construction of conditional knockout mice.
The heterotrimeric G protein Gsa couples many receptors to adenylyl cyclase and is essential for hormone-stimulated cAMP generation. Previous…
|UTX LoxP Mouse
(Mutant Mouse: Kdm6a (lysine (K)-specific demethylase 6A))
UTX-flox. Conditional knockout mice for the histone demethylase UTX (Kdm6a) conditional knockout will help understand its role as a tumor suppressor.
Di- and tri-methylations on histone H3 lysine 27 (H3K27me2 and H3K27me3) are epigenetic marks for…
(Mutant Mouse: MMTV-Cre (Mammary tumor virus long terminal repeat-Cre recombinase))
Cre-recombinase under the control of mouse mammary tumor virus long terminal repeat (MMTV) was expressed in the salivary gland and mammary epithelial cells of adult mice, and induced recombination in all tissues.
The Cre recombinase from bacteriophage…
(Mutant Mouse: WAP-Cre (whey acidic protein promoter directs Cre recombinase))
Cre-recombinase under the control of the whey acidic acid protein was only detected in alveolar epithelial epithelial cells of mammary tissue during lactation, and transcription occurred at all stages of mammary development.
The Cre recombinase from…
|Stat5a LoxP/Stat5b LoxP (Stat5a/Stat5b tm2Mam) Mouse
(Mutant Mouse: Stat5a/b)
Conditional knockout of Stat5a and Stat5b: Combined deletion of conserved Stat5a and Stat5b in mammary epithelium at different times during pregnancy reveal multiple distinct functions.
The signal transducer and activator of transcription (STAT…
|Stat5a KO(Stat5a tm1Mam) Mouse
(Mutant Mouse: Stat 5a (Signal transducer and activator of transcription))
Stat 5a Knockout: Stat5a deficiency results in the loss of prolactin-dependent mammary gland development and lactogenesis.
Prolactin induces mammary gland development and lactogenesis. Binding of Prolactin to its receptor leads to the phosphorylation…