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Research Resources

Resources listed below (reagents, data, protocols, etc.) are derived from publicly available information provided by NIDDK-funded investigators, projects, and publications. Many clinical resources listed are available through the NIDDK Central Repository​.  Please direct inquiries to the contact provided for each resource.

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Resource NameDescription
NIDDK Information Network (dkNET) The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of dkNET is to develop a community-based network for integration (Summary)
Smad4 LoxP Mouse (Mutant Mouse: Smad4) Smad4 conditional KO.  Inactivation of LoxP-flanked Smad 4 makes it possible to explore the role of Smad 4 in embryonic development of different tissues and in tumorigenesis.
 
Members of the TGF-b superfamily (which includes Bone Morphogenic Protein (Summary)
Smad4 KO (Smad4 tm1Cxd) Mouse (Mutant Mouse: Smad4) Smad4 knockout: Smad 4 is essential for epiblast proliferation and mesoderm induction in early embryogenesis.
 
The TGF-β-related superfamily plays an important role in multiple biological systems including embryogenesis.  TGF-β ligands activate specific (Summary)
Smad3 KO (Smad3 tm1Cxd) Mouse (Mutant Mouse: Smad3 (MAD homolog 3 (Drosophila))) Smad 3 knockout: Increased susceptibility to opportunistic infections and massive abscesses result from impaired TGF-β-mediated regulation of T cell activation and mucosal immunity.
 
Smad3 is one of the intracellular mediators that transduce signals (Summary)
Sirt6 LoxP (Sirt6 tm1.1Cxd) Mouse (Mutant Mouse: Sirt6) Generation of floxed Sirtuin 6 for the construction of conditional knockout mice
 
The Sirtuins (Sirt1-7), a family of seven proteins related to yeast Sir2, are histone deacetylases that regulate many critical biological processes including genomic (Summary)
Sirt3 KO (Sirt3 tm1.1Cxd) Mouse (Mutant Mouse: Sirt3) Sirt3 KO: Sirt3 is a mitochondrial-localized tumor suppressor that maintains mitochondrial integrity and metabolism during stress.
 
SirT3 is a mitochondrial protein that is a member of the Sirtuin family of NAD-dependent protein deacetylases.  Sirt3(-/-) (Summary)
Sirt1 LoxP (Sirt1 tm1Cxd) Mouse (Mutant Mouse: Sirt1) Generation of floxed Sirtuin 1 Exon5-Exon6 for the construction of conditional knockout mice
 
Sirtuin 1 (Sirt1), a homolog of yeast Sir 2, is an NAD-dependent histone and protein deacetylase.  It has a wide range of biological functions, ranging from (Summary)
Sirt1 KO (Sirt1 tm1.1Cxd) Mouse (Mutant Mouse: Sirt1 (sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)) Sirt1 knockout: Sirt1, a protein deacetylase, is a tumor suppressor that promotes genome stability and regulates proteins involved in energy metabolism.
 
Yeast Sir2, a nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase, has been (Summary)
S1pr3 KO Mouse (Mutant Mouse: s1pr3) A Spingosine-1-phosphate Receptor-3 (S1pr3) knockout mouse


Sphingosine-1-phosphate (S1P), a sphingolipid metabolite, activates cell signaling by interacting with a family of G-protein-coupled cell-surface S1P receptors that activate different and (Summary)
S1pr2 KO Mouse (Mutant Mouse: S1pr2) A Spingosine-1-phosphate Receptor-2 (S1pr2) knockout mouse


Sphingosine-1-phosphate (S1P), a sphingolipid metabolite, activates cell signaling by interacting with a family of G-protein-coupled cell-surface S1P receptors that activate different and (Summary)
S1pr1 LoxP (S1pr1 tm2Rlp) Mouse (Mutant Mouse: S1pr1) A conditional knockout mouse for S1pr1
 
Sphingosine-1-phosphate (S1P) is a potent bioactive lipid that activates a family of G-protein coupled receptors, S1P1, S1P2, S1P3, S1P4 and S1P5. The S1P1 receptor is widely expressed and has critical functions (Summary)
S1pr1 KO (S1pr1 tm1Rlp) Mouse (Mutant Mouse: S1pr1 (spingosine-1-phosphate receptor 1)) A Sphingosine-1-phosphate Receptor-1 (S1pr1) knockout mouse
 
Sphingosine-1-phosphate (S1P) is a potent bioactive lipid that activates a family of G-protein coupled receptors, S1P1, S1P2, S1P3, S1P4 and S1P5. The S1P1 receptor is widely expressed and (Summary)
Bcl-x LoxP (Bcl2l1 tm1.1Mam) Mouse (Mutant Mouse: Bcl2l1(Bcl2-like 1)) Floxed Bcl-x: Conditional knockout of pro-survival Bcl-x in primordial germ cells was used to study the balance between pro-aptoptotic Bax during embryogenesis.

Bcl-x is a pro-survival protein that opposes the pro-apoptotic action of Bax which interacts (Summary)
Brca1 LoxP Mouse (Mutant Mouse: Brca1 (Breast cancer1)) BRCA1 conditional knockouts.  BRCA1 LoxP mutations allow selective inactivation of the gene in mammary epithelial cells (accelerating breast tumor formation) and in cardiomyocytes (impairing cardiac remodeling that may increase the risk of heart failure (Summary)
Brca1(Brca1tm1Cxd) Mouse (Mutant Mouse: Brca1 (Breast cancer1)) Knockout of the BRCA1 (Breast Cancer 1) gene impairs DNA damage repair resulting in embryonic death.
 
Germ-line mutations of the nuclear protein BRCA1 are responsible for increased susceptibility to familial breast and ovarian cancers.  Targeted mutation (Summary)
Fgfr1 LoxP Mouse (Mutant Mouse: Fgfr1 (Fibroblast Growth Factor Receptor 1)) FGFR1 conditional knockouts.  Inactivation of FGFR1 LoxP in limb mesenchyme early in embryogenesis shows that FGFR1 is indispensable for normal limb development
 
Fibroblast Growth Factor Receptor 1 (FGFR1) is primarily expressed in the mesenchyme (Summary)
FGFR2 knockout is an embryonic lethal mutation and blocks limb bud initiation. (Mutant Mouse: Fgfr2 KO (Fgfr2 tm1Cxd) Mouse) FGFR2 knockout is an embryonic lethal mutation and blocks limb bud initiation.
 
Fibroblast Growth Factor Receptor 2 (FGFR2) is a high affinity receptor for several members of the FGF family.  The FGFR2 gene was inactivated by deleting the entire immunoglobulin-like (Summary)
Fgfr3 KO Mouse (Mutant Mouse: Fgfr3) FGFR3 knockout. Complete knockout of the FGFR3 gene, the gene in which missense mutants cause short statue achrondorplasia, fails to restrain cartilage growth at the bone growth plate, allowing bones to elongate excessively but fail to ossify.
 
Endochondral (Summary)
Fgfr4 KO Mouse (Mutant Mouse: Fgfr4) FGFR4 knockout: Lung alveoli fail to develop normally in double mutant with FGFR4 and FGFR3 knockouts
 
The Fibroblast Growth Factor Receptor (FGFR) 4 gene was inactivated by targeted disruption and homozygous recombination to study its possible role (Summary)
Gaucher Gba-444 knock-in(Gba tm2Rlp) Mouse (Mutant Mouse: Gba (glucosidase, beta, acid).Knock-in P444L ±A456P mimic Gaucher disease.) Gba-444 knock-in mice carrying the milder L444P Gaucher disease mutation (Gba-L444P mice) and the severe Gaucher disease mutation (Gba-L444P A456P mice)
 
Gba-L444P and Gba-L444P A456P mice, respectively, carry common gene mutations for milder or severe (Summary)
M1 Muscarinic receptor KO (Chrm1 tm1Jwe) Mouse (Mutant Mouse: Chrm1 (Cholinergic Receptor, muscarinic 1)) M1 Muscarinic Receptor Knockout: support involvement in cognitive processes
 
The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively couple (Summary)
M2 Muscarinic receptor KO (Chrm2 tm1Jwe) Mouse (Mutant Mouse: Chrm2) M2 Muscarinic Receptor Knockout: role in learning and memory, and mediating analgesic effectsof muscarinic agonists
 
The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to (Summary)
M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity. (Mutant Mouse: M3 Muscarinic receptor KO (Chrm3 tm1Jwe) Mouse) M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.
 
The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple (Summary)
M4 Muscarinic receptor KO (Chrm4 tm1Jwe) Mouse (Mutant Mouse: Chrm4) M4 Muscarinic Receptor Knockout: Activation of M4R may reduce the reinforcing effect of drugs of abuse, and contribute to the analgesic effects observed after administration of muscarinic agonists.
 
The five Muscarinic Acetylcholine (ACh) receptors (Summary)
M5 Muscarinic receptor KO (Chrm5 tm1Jwe) Mouse (Mutant Mouse: Chrm5) M5 Muscarinic Receptor Knockout: Deficiency of M5Rs reduces drug-seeking behavior
 
The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively (Summary)
mEpoR KO / Tg(hEpoR) Mouse (Mutant Mouse: human erythropoietin receptor transgene bred onto a mouse erythropoietin receptor null background) mEpoR-/- hEpoR+: The mouse Erythropoietin Receptor knockout that contains a human Erythropoietin Receptor transgene can be used to define the potency of recombinant erythropoietin preparations used to treat anemia associated with chronic kidney disease (Summary)
Podocin-rtTA (Tg(NPHS2-rtTA2*M2)1Jbk Mouse (Mutant Mouse: The tet transactivator (rtTA) gene placed under the control of the human NPHS2 gene).) Reverse tetracycline-controlled transgenic mouse model (Tet-On) under the control of the specific promoter for the glomerular podocyte protein (Podocin, NPHS2)
 
Podocytes are post-mitotic epithelial cells that are positioned on the exterior aspect (Summary)
Sphk2 KO Mouse (Mutant Mouse: Sphk2 (Sphingosine Kinase 2)) A knockout mouse for Sphingosine kinase 2 (Sphk2)


Sphingosine kinase 1 and 2 are enzymes that produce sphingosine-1-phosphate (S1P), a potent bioactive compound that activates a family of G-protein coupled receptors known as S1P receptors.  Triggering (Summary)
Personalized Body Weight Management System Using Monitoring Devices and Mathematical Models of MetabolismAttempts to manage body weight are often unsuccessful or only temporary. This is, in part, due to antiquated dieting methods that attempt to address calorie consumption while ignoring metabolic and physical changes. It is becoming clear that personalized (Summary)
Body Weight Simulator - Java Applet for Modeling Human Metabolism and Energy Expenditure for Adaptive Dieting and Exercise RegimensKnown methods for predicting weight loss fail to account for slowing of metabolism as weight is lost and therefore overestimate the degree of weight loss. While this limitation of the 3500 Calorie per pound rule has been known for some time, it was not (Summary)