Resources listed below (reagents, data, protocols, etc.) are derived from publicly available information provided by NIDDK-funded investigators, projects, and publications. Many clinical resources listed are available through the NIDDK Central Repository. Please direct inquiries to the contact provided for each resource.
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|Gs Alpha LoxP (Gnas tm1Lsw) Mouse
(Mutant Mouse: GNAS (guanine nucleotide binding protein, alpha stimulating))
Generation of a floxed Gnsa gene for the G-protein Gsα for the construction of conditional knockout mice.
The heterotrimeric G protein Gsa couples many receptors to adenylyl cyclase and is essential for hormone-stimulated cAMP generation. Previous…
|M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.
(Mutant Mouse: M3 Muscarinic receptor KO (Chrm3 tm1Jwe) Mouse)
M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.
The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to…
|Sirt1 KO (Sirt1 tm1.1Cxd) Mouse
(Mutant Mouse: Sirt1 (sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae))
Sirt1 knockout: Sirt1, a protein deacetylase, is a tumor suppressor that promotes genome stability and regulates proteins involved in energy metabolism.
Yeast Sir2, a nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase, has been…
|Sirt1 LoxP (Sirt1 tm1Cxd) Mouse
(Mutant Mouse: Sirt1)
Generation of floxed Sirtuin 1 Exon5-Exon6 for the construction of conditional knockout mice
Sirtuin 1 (Sirt1), a homolog of yeast Sir 2, is an NAD-dependent histone and protein deacetylase. It has a wide range of biological functions, ranging from…
|Sirt3 KO (Sirt3 tm1.1Cxd) Mouse
(Mutant Mouse: Sirt3)
Sirt3 KO: Sirt3 is a mitochondrial-localized tumor suppressor that maintains mitochondrial integrity and metabolism during stress.
SirT3 is a mitochondrial protein that is a member of the Sirtuin family of NAD-dependent protein deacetylases…
|Mutant Mouse Regional Resource Centers
The MMRRC distributes and cryopreserves scientifically valuable, genetically engineered mouse strains and mouse ES cell lines with potential value for the genetics and biomedical research community. We are a national network of breeding and…
|Mouse Metabolic Phenotyping Centers
The MMPC is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice.
|Knock-Out Mouse Project
The Knockout Mouse Project (KOMP) is a trans-NIH initiative that aims to generate a comprehensive and public resource comprised of mouse embryonic stem (ES) cells containing a null mutation in every gene in the mouse genome. Live knockout…