Resources listed below (reagents, data, protocols, etc.) are derived from publicly available information provided by NIDDK-funded investigators, projects, and publications. Many clinical resources listed are available through the NIDDK Central Repository. Please direct inquiries to the contact provided for each resource.
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|Gs Alpha LoxP (Gnas tm1Lsw) Mouse
(Mutant Mouse: GNAS (guanine nucleotide binding protein, alpha stimulating))
||Generation of a floxed Gnsa gene for the G-protein Gsα for the construction of conditional knockout mice.
The heterotrimeric G protein Gsa couples many receptors to adenylyl cyclase and is essential for hormone-stimulated cAMP generation. Previous …
|M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.
(Mutant Mouse: M3 Muscarinic receptor KO (Chrm3 tm1Jwe) Mouse)
||M3 Muscarinic Receptor Knockout mice are hypophagic, lean, and have improved glucose tolerance and insulin sensitivity.
The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple …
|Sirt1 KO (Sirt1 tm1.1Cxd) Mouse
(Mutant Mouse: Sirt1 (sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae))
||Sirt1 knockout: Sirt1, a protein deacetylase, is a tumor suppressor that promotes genome stability and regulates proteins involved in energy metabolism.
Yeast Sir2, a nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase, has been …
|Sirt1 LoxP (Sirt1 tm1Cxd) Mouse
(Mutant Mouse: Sirt1)
||Generation of floxed Sirtuin 1 Exon5-Exon6 for the construction of conditional knockout mice
Sirtuin 1 (Sirt1), a homolog of yeast Sir 2, is an NAD-dependent histone and protein deacetylase. It has a wide range of biological functions, ranging from …
|Sirt3 KO (Sirt3 tm1.1Cxd) Mouse
(Mutant Mouse: Sirt3)
||Sirt3 KO: Sirt3 is a mitochondrial-localized tumor suppressor that maintains mitochondrial integrity and metabolism during stress.
SirT3 is a mitochondrial protein that is a member of the Sirtuin family of NAD-dependent protein deacetylases. Sirt3(-/-) …
|Mutant Mouse Regional Resource Centers
||The MMRRC distributes and cryopreserves scientifically valuable, genetically engineered mouse strains and mouse ES cell lines with potential value for the genetics and biomedical research community. We are a national network of breeding and distribution …
|Mouse Metabolic Phenotyping Centers
||The MMPC is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice. (Summary)|
|Knock-Out Mouse Project
||The Knockout Mouse Project (KOMP) is a trans-NIH initiative that aims to generate a comprehensive and public resource comprised of mouse embryonic stem (ES) cells containing a null mutation in every gene in the mouse genome. Live knockout animals will …