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Research Materials

Biological materials such as antibodies, cell lines, and mouse models, experimental therapeutic compounds, and devices developed by NIDDK scientists are made available to the global research community for further research and development.  

A selection of research materials appear below. You can also browse the NIH Office of Technology Transfer's database of resources available for commercial licensing and the NIDDK Central Repository's collection of data and samples, all of which may be available to academics through Material Transfer Agreements. If you are interested in obtaining a Material Transfer Agreement, please contact the NIDDK Technology Advancement Office by email.

If you are a member of industry and are interested in licensing products for commercial use, visit our Licensing page for more information.​

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Research Material DescriptionPrincipal Investigator
MEN1, the gene associated with multiple endocrine neoplasia type 1, menin polypeptides and uses thereof (U.S. Patent Number 7,358,347)
The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated…
Sunita K. Agarwal, Ph.D.
Use of homo sapiens chromosome 1 open reading frame 28 (c1orf28) in the diagnosis of hyperparathyroidism-jaw tumor syndrome (U.S. Patent Application Number WO 2003094860 A3)

The present invention provides an isolated or purified oligonucleotide consisting essentially of the nucleotide sequence of Clorf28 and comprising a mutation; a fragment of the oligonucleotide; a vector comprising the oligonucleotide or fragment…

Sunita K. Agarwal, Ph.D.
Anti-HIV Acylthiol & Thioether prodrugs (U.S. Patent Number 12/414,321)
These inventions provide the compositions, pharmaceutical carrier, and usages of the new Acylthiols (E-329-2000 family) and Thioether pro-drug (E-177-2010 family) compounds in treatment of retroviral infections such as HIV. These compounds target the…
Daniel Appella, Ph.D.
Programmable self-assembled nanostructures based on sidechain-modified pna for the multivalent display of ligands (U.S. Patent Number EP 2569328 A2)

The invention concerns compositions comprising strands of polynucleotide and strands of PNA, each PNA strand comprising:

  • (i) from 2 to 50 nucleobase subunits and
  • (ii) one or more gamma substituents.

The PNA strands are complementary to at least a…

Daniel Appella, Ph.D.
A3 Adenosine Receptor Antagonists (U.S. Patent Number 6,376,521)

This invention relates to a method of decreasing intraocular pressure by administrating an A3 subtype adenosine receptor antagonist, a calmodulin antagonist or an antiestrogen such as tamoxifen. ​

Kenneth A. Jacobson, Ph.D.
Epibatidine and derivatives, compositions and methods of treating pain (Patent Number U.S. 5,314,899)
The present invention is directed to compounds, compositions and methods of treating pain, and derivatives that have potent analgetic activity. The compounds have the formula: ##STR1## wherein R.sup.1 is selected from H, lower alkyl, C.sub.3 -C.sub.9…
H. Martin Garraffo, Ph.D.
Nicotinic acetylcholine receptor agonists (U.S. Patent Application Number WO 2011116282 A3)

The invention provides novel nicotinic acetylcholine receptor agonists, for example, phaiitasmidine and derivatives thereof, for example a compound of formula (I). Also disclosed are methods of treating disorders responsive to nicotinic acetylcholine…

H. Martin Garraffo, Ph.D.
PNA-Detection of Pathogens (U.S. Patent Number 13/592,490)

The laboratory of Daniel Appella, PhD. has developed a prototype HIV testing kit that employs a peptide nucleic acid probe to capture HIV RNA recovered from patient blood.  The probe targets a highly conserved segment of the Gag sequence.   Initial…

Daniel Appella, Ph.D.
MUP-tTA Mouse

Tetracycline-responsive transcriptional activator driven by the liver-specific mouse major urinary protein promoter (MUP-tTA).

The E. Coli tetracycline operon regulatory system was used to generate a liver-specific transcription activation system that…

T. Jake Liang, M.D.
Alb-tTA (Tg(Alb1-tTA)3123Lng) Mouse

Tetracycline-responsive transcriptional activator driven by the liver-specific mouse albumin promoter (Alb-tTA).

The E. Coli tetracycline operon regulatory system was used to generate a liver-specific transcription activation system that was inhibited…

T. Jake Liang, M.D.
Gs Alpha LoxP (Gnas tm1Lsw) Mouse

Generation of a floxed Gnsa gene for the G-protein Gsα for the construction of conditional knockout mice.

The heterotrimeric G protein Gsa couples many receptors to adenylyl cyclase and is essential for hormone-stimulated cAMP generation.  Previous…

Lee S. Weinstein, M.D.
UTX LoxP Mouse

UTX-flox.  Conditional knockout mice for the histone demethylase UTX (Kdm6a) conditional knockout will help understand its role as a tumor suppressor.

Di- and tri-methylations on histone H3 lysine 27 (H3K27me2 and H3K27me3) are epigenetic marks for…

Kai Ge, Ph.D.
Tg(MMTV-Cre)#Mam Mouse

Cre-recombinase under the control of mouse mammary tumor virus long terminal repeat (MMTV) was expressed in the salivary gland and mammary epithelial cells of adult mice, and induced recombination in all tissues.

The Cre recombinase from bacteriophage…

Lothar Hennighausen, Ph.D.
Tg(Wap-cre)11738Mam Mouse

Cre-recombinase under the control of the whey acidic acid protein was only detected in alveolar epithelial epithelial cells of mammary tissue during lactation, and transcription occurred at all stages of mammary development.

The Cre recombinase from…

Lothar Hennighausen, Ph.D.
Stat5a LoxP/Stat5b LoxP (Stat5a/Stat5b tm2Mam) Mouse

Conditional knockout of Stat5a and Stat5b: Combined deletion of conserved Stat5a and Stat5b in mammary epithelium at different times during pregnancy reveal multiple distinct functions.

The signal transducer and activator of transcription (STAT…

Lothar Hennighausen, Ph.D.
Stat5a KO(Stat5a tm1Mam) Mouse

Stat 5a Knockout: Stat5a deficiency results in the loss of prolactin-dependent mammary gland development and lactogenesis.

Prolactin induces mammary gland development and lactogenesis.  Binding of Prolactin to its receptor leads to the phosphorylation…

Lothar Hennighausen, Ph.D.
Stat1LoxP (Stat1 tm1Mam) Mouse

Selective inactivation of Stat 1 in mammary cells indicates that its effect as a tumor suppressor in breast is direct.

STAT1 is considered a tumor suppressor, but it is not known if this effect occurs directly in mammary cells or secondarily by…

Lothar Hennighausen, Ph.D.
Sphk1 KO Mouse

A Sphingosine kinase 1 (Sphk1) knockout mouse.

Sphingosine kinase 1 and 2 are enzymes that produce sphingosine-1-phosphate (S1P), a potent bioactive compound that activates a family of G-protein coupled receptors known as S1P receptors.  Triggering…

Richard L. Proia, Ph.D.
Therapeutic Polypeptides and Their Use (U.S. Patent Application Number 61/890,585)

NIDDK investigators have developed a synthetic polypeptide with beneficial effects and prospective treatment of chronic kidney disease (CKD).  End stage renal disease (ESRD) is a major health and economic burden and requires transplantation or…

Peter Yuen, Ph.D.
M2 Muscarinic receptor KO (Chrm2 tm1Jwe) Mouse

M2 Muscarinic Receptor Knockout: role in learning and memory, and mediating analgesic effectsof muscarinic agonists

The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to…

Jürgen Wess, Ph.D.
Small volume viscometer

NIDDK scientists have developed a capillary-based device and system for measuring the rheological properties of solutions of synthetic and biological polymers. The device automatically serially dilutes and varies the flow rate of a sample, permitting…

Allen P. Minton, Ph.D.
Inducible podocyte-specific gene expression in transgenic mice

The podocyte plays a key role in glomerular function and glomerular disease. To facilitate studies of podocyte function, we have developed a transgenic mouse model with inducible expression in the podocyte. The tetracycline-inducible transgenic…

Jeffrey B. Kopp, M.D.
DNA sequence acting as an insulator for the effects of cis-acting regulatory elements

A newly characterized chromatin insulator element isolated from the DNA of a higher eukaryotic organism and contained in vector constructs is described. The insulator element of the invention comprises a DNA sequence which contains a 5’ constitutive…

Gary Felsenfeld, Ph.D., NIH Distinguished Investigator
Method for Spectrally Selective B1 Insensitive T2 Preparation Contrast Enhancement for High Field Magnetic Resonance Imaging

A T2 preparation sequence uses a segmented BIR-4 adiabatic pulse with two substantially equal delays and is insensitive to B1 field variations and can simultaneously suppress fat signals with low specific absorption rate (SAR). An adiabatic reverse…

Ronald Ouwerkerk, Ph.D.