Continuation of the Human Pancreas Analysis Program (HPAP)

May 2020 Council

Lead Division/Office

DEM

Point(s) of Contact

Oliver Blondel, Ph.D.; Xujing Wang, Ph.D.

Executive Summary

This limited competition would support a single cooperative agreement application to continue the mission of the existing Human Pancreas Analysis Program (HPAP). The HPAP is a large data- and resource-generation program that performs deep phenotyping of the human endocrine pancreas and its interaction with the immune system to better understand the molecular events that precede and lead to the beta cell loss in type 1 diabetes (T1D). HPAP datasets are shared with the research community through a searchable database called PANC DB (https://hpap.pmacs.upenn.edu/). HPAP is a component of the Human Islet Research Network or HIRN that was created in 2014 to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional human beta cell mass.