Dietary Biomarkers of Intake and Exposure

September 2019 Council

Lead Division/Office

DDN

Point(s) of Contact

Padma Maruvada, Ph.D.

Executive Summary

Nutritional epidemiological studies explore the role of dietary constituents in human health and disease. Dietary exposure information, which is critical for establishing such associations, is often derived from self-reported Food Frequency Questionnaires (FFQ), food diaries and other similar dietary assessment instruments. However, these instruments are often liable for systematic errors and further confounded by incomplete databases used for converting the intake information. There is a critical need for independent and objective biomarkers of dietary intake and to validate these assessment methods. The current explosion in the application of unbiased metabolomics platforms provides an unprecedented opportunity for measuring both nutrients and non-nutrients, based on their chemical composition, giving us larger chemical metabolite panels as candidate biomarkers of intake. The purpose of this initiative is to seek support for the development of metabolomics-based dietary intake biomarkers and validate them against current benchmark dietary assessment approaches.