Limited Competition: Continued Follow-up of Subjects and Initiation of a Second Case-control Cohort in The Environmental Determinants of Diabetes in The Young Study (TEDDY)

May 2020 Council

Lead Division/Office


Point(s) of Contact

Arthur L. Castle, Ph.D.; Beena Akolkar, Ph.D.

Executive Summary

Type 1 diabetes is a serious and burdensome chronic disease that usually affects children and young adults. The rate of type 1 diabetes incidence is rising worldwide, especially in the very young. These findings suggest that environmental triggers are responsible for increased and accelerated rates of disease in genetically susceptible individuals. TEDDY was established to identify environmental triggers of T1D, such as infectious agents, dietary factors and/or psychosocial factors, in genetically susceptible individuals that trigger or protect against the development of islet autoimmunity and T1D. TEDDY’s overarching goal is to elucidate the etiology and pathogenesis of T1D and to inform new strategies to prevent or delay the disease. To date, TEDDY has shed light on the heterogeneity of the disease process. TEDDY completed recruitment of the subjects in 2010; retention and data accrual rates are meeting study projections. The study was designed to follow subjects for 15 years to accrue approximately 800 subjects who develop autoantibodies and 400 subjects who develop diabetes. The NIDDK recommends renewal of the TEDDY program to continue to follow the subjects till age 15 and to conduct a second case-control analysis. The program will continue to provide open access to all data and results.