Nuclear Architecture and Regulation of Hematopoiesis

May 2022 Council

Lead Division/Office


Point(s) of Contact

Cindy Roy, Ph.D., Shilpa Hattangadi, M.D.

Executive Summary

Emerging evidence suggests nuclear architecture (e.g. nuclear membrane/envelope, nucleoskeleton, and nuclear structure) significantly impacts cellular developmental states and gene expression, likely through regulation and modification of chromatin conformation and states. The application of structural biology, mechanobiology, cell and developmental biology, and new high resolution cellular imaging tools to hematopoiesis may identify new developmental regulators and may uncover novel therapeutic pathways for inherited blood disorders, such as the Congenital Dyserythropoietic Anemias or acquired blood disorders of aging.