Rare and Atypical Diabetes Network (RADIANT) Renewal

May 2022 Council

Lead Division/Office


Point(s) of Contact

Ellen Leschek, M.D.; Beena Akolkar, Ph.D.; Christine Lee, M.D., M.S.

Executive Summary

The Rare and Atypical Diabetes Network (RADIANT) is multidisciplinary group of investigators with expertise in diabetes, clinical phenotyping, genetics, metabolomics, and bioinformatics at 14 clinical centers, 5 specialized laboratories, and a data coordinating center. RADIANT is enrolling individuals and families with rare and atypical diabetes for in-depth, phenotypic and genetic analyses to help characterize new subtypes of diabetes and to provide insights on mechanisms underlying more common forms of type 2 diabetes. To date, 729 individuals have been screened and of these, 160 individuals have been found to have a new, atypical form of diabetes and were enrolled for deeper phenotyping measures and genetic analyses. Additionally, a data and biospecimen repository is being created to facilitate broader research efforts to understand heterogeneity in type 2 diabetes and to foster precision medicine efforts with more targeted diagnostics and therapeutics.