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Mechanisms and Interactions of SARS-CoV-2 and COVID-19 in Organ Systems and Outcomes of Specific Interest to NIDDK

May 2020 Council

Lead Division/Office

DDN

Point(s) of Contact

Bonnie Burgess-Beusse, Ph.D.; Maren Laughlin, Ph.D.;  Afshin Parsa, M.D., M.P.H.;  David Saslowsky, Ph.D.; Ivonne Schulman, M.D. 

Executive Summary

Emerging evidence suggests that organs and tissues that manifest diseases within NIDDK’s mission are targeted by SARS-CoV-2, which contributes significantly to COVID-19 morbidity and leads to organ-specific complications after recovery from infection. How this occurs is largely unknown, however understanding the mechanisms by which SARS-CoV-2 exerts these effects is expected to contribute to additional strategies for management of SARS-CoV-2 infected individuals with concurrent diseases and conditions or new organ- or system-specific sequalae of infection. NIDDK proposes to support new research in human subjects, isolated tissues, cells, or model organisms to delineate and address mechanisms by which people with diseases of specific interest to NIDDK have poor outcomes from COVID-19 infection and how SARS-CoV-2 and COVID-19 lead to acute or chronic damage to organs of interest to NIDDK. The knowledge gained will contribute a new evidence base to accelerate advances in diagnostics, therapeutics, clinical management, and public health innovation, as related to diseases and outcomes of interest to NIDDK.