Multidisciplinary Research on HIV Cure within the Mission of the NIDDK

May 2020 Council

Lead Division/Office

DDN, KUH, DEM

Point(s) of Contact

Peter Perrin, Ph.D.

Executive Summary

The initiative encourages multidisciplinary teams to engage in basic and/or clinical HIV cure research within the mission of the NIDDK. This includes characterization of HIV reservoirs and mechanisms associated with viral latency, post-treatment control, and viral rebound in the gastrointestinal tract, the male genital tract, adipose tissue, and the kidney as well as other tissues within the NIDDK’s mission. Development of therapeutic strategies for eradicating or controlling residual virus within these tissues using in vitro, ex vivo, and animal models is also appropriate for this initiative. Teams should be comprised of researchers with demonstrable expertise in HIV cure science and the biology, physiology, and metabolism of the host tissue(s) being evaluated. Because this initiative addresses the need to develop such teams, there is no expectation that teams necessarily have previous publications with each other or otherwise have a history of extensive previous collaboration.