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Re-competition of GUDMAP – Lower Urinary Tract Develop Molecular Anatomy Project

September 2019 Council

Lead Division/Office

KUH

Point(s) of Contact

Deborah K. Hoshizaki, Ph.D.

Executive Summary

The purpose of the GenitoUrinary Development Molecular Anatomy Project (GUDMAP) is to provide fundamental information necessary to guide new strategies for repair or replacement of damaged organs; to generate new insights into pathologic processes underlying developmental defects and disease; and to provide a thorough understanding of organogenesis so congenital malformations might be prevented and treated. This GUDMAP initiative focuses on a detailed interrogation of the lower urinary tract to identify new cell types and establish their cell signatures, categorize developmental events, and interrogate a well-chosen set of murine disease or injury models for kidney and lower urinary tract to define disease-associated cell signatures. Where possible analyses of human tissue will be carried out to allow comparison of the cell types and developmental events in mouse.