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Supporting Research in Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)

May 2019 Council

Lead Division/Office

DDN

Point(s) of Contact

Aynur Unalp-Arida, M.D., Ph.D.

Executive Summary

Recurrent acute and chronic pancreatitis in both adults and children are associated with significant morbidity, including pancreatogenic diabetes and increased risk of pancreatic cancer, now the 3rd leading cause of cancer death in the U.S. In addition, new onset type 2 diabetes in adults in a small proportion of cases is the initial manifestation of underlying pancreatic cancer.

Research progress in diseases of the exocrine pancreas (chronic pancreatitis (CP), pancreatogenic diabetes mellitus, and pancreatic cancer) has been hampered by disease heterogeneity, limitations of previous small cross-sectional studies, inability to safely obtain pancreatic tissue for study, and the lack of longitudinal epidemiology studies, genetic testing, and integral biomarker development for disease progression and risk stratification to advance patient surveillance. Mechanism-based research of chronic pancreatitis has suffered from the lack of systematically collected clinical measures in large national administrative databases and electronic health records linked with biospecimens.

The proposed concept would leverage and build upon resources arising from the current NIDDK and NCI-supported Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer. Currently this consortium is conducting multiple longitudinal studies in chronic pancreatitis and diabetes in children and adults.