Extension of the Urinary Stone Disease Research Network (USDRN) PUSH Study

September 2019 Council

Lead Division/Office


Point(s) of Contact

Ziya Kirkali, M.D.; Chris Mullins, Ph.D.

Executive Summary

The NIDDK’s Urinary Stone Disease Research Network (USDRN) seeks to improve our understanding and treatment of urinary stone disease. The USDRN is currently conducting two clinical protocols, the Prevention of Urinary Stones with Hydration (PUSH) Study (a randomized clinical trial) and the Study to Enhance Understanding of Stent Associated Symptoms (STENTS) (an observational cohort study). The randomized PUSH Study will assess if behavioral modifications to increase fluid intake impacts future urologic stone events. A 3-year extension of the USDRN is proposed to fully meet PUSH enrollment and participant follow-up targets, and to allow for resources for data analysis and dissemination of study findings. Successful completion of the PUSH Study will provide key insights expected to directly improve clinical management strategies for this common urologic condition.