Anthony V. Furano, M.D.

Section Chief: Genomic Structure and Function Section, Laboratory of Cell & Molecular Biology

Scientific Focus Areas: Cancer Biology, Computational Biology, Genetics and Genomics, Molecular Biology and Biochemistry, Structural Biology

Publications

A selection of recent and significant publications can be viewed below.

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Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations.: Shen B, Chapman JH, Custance MF, Tricola GM, Jones CE, Furano AV.; Elife (2020 Jan 6) 9. Abstract/Full Text
Cryptic genetic variation enhances primate L1 retrotransposon survival by enlarging the functional coiled coil sequence space of ORF1p.: Furano AV, Jones CE, Periwal V, Callahan KE, Walser JC, Cook PR.; PLoS Genet (2020 Aug) 16:e1008991. Abstract/Full Text
Repair of naturally occurring mismatches can induce mutations in flanking DNA.: Chen J, Miller BF, Furano AV.; Elife (2014 Apr 29) 3:e02001. Abstract/Full Text
L1 retrotransposition requires rapid ORF1p oligomerization, a novel coiled coil-dependent property conserved despite extensive remodeling.: Naufer MN, Callahan KE, Cook PR, Perez-Gonzalez CE, Williams MC, Furano AV.; Nucleic Acids Res (2016 Jan 8) 44:281-93. Abstract/Full Text
Breaking bad: The mutagenic effect of DNA repair.: Chen J, Furano AV.; DNA Repair (Amst) (2015 Aug) 32:43-51. Abstract/Full Text

Additional Publications

The challenge of ORF1p phosphorylation: Effects on L1 activity and its host.: Furano AV, Cook PR.; Mob Genet Elements (2016 Jan-Feb) 6:e1119927. Abstract/Full Text
Polymerization and nucleic acid-binding properties of human L1 ORF1 protein.: Callahan KE, Hickman AB, Jones CE, Ghirlando R, Furano AV.; Nucleic Acids Res (2012 Jan) 40:813-27. Abstract/Full Text
The mutational spectrum of non-CpG DNA varies with CpG content.: Walser JC, Furano AV.; Genome Res (2010 Jul) 20:875-82. Abstract/Full Text
CpG dinucleotides and the mutation rate of non-CpG DNA.: Walser JC, Ponger L, Furano AV.; Genome Res (2008 Sep) 18:1403-14. Abstract/Full Text
Fitness cost of LINE-1 (L1) activity in humans.: Boissinot S, Davis J, Entezam A, Petrov D, Furano AV.; Proc Natl Acad Sci U S A (2006 Jun 20) 103:9590-4. Abstract/Full Text
Human population genetic structure and diversity inferred from polymorphic L1(LINE-1) and Alu insertions.: Witherspoon DJ, Marchani EE, Watkins WS, Ostler CT, Wooding SP, Anders BA, Fowlkes JD, Boissinot S, Furano AV, Ray DA, Rogers AR, Batzer MA, Jorde LB.; Hum Hered (2006) 62:30-46. Abstract/Full Text
The structures of mouse and human L1 elements reflect their insertion mechanism.: Martin SL, Li WL, Furano AV, Boissinot S.; Cytogenet Genome Res (2005) 110:223-8. Abstract/Full Text
The recent evolution of human L1 retrotransposons.: Boissinot S, Furano AV.; Cytogenet Genome Res (2005) 110:402-6. Abstract/Full Text
The insertional history of an active family of L1 retrotransposons in humans.: Boissinot S, Entezam A, Young L, Munson PJ, Furano AV.; Genome Res (2004 Jul) 14:1221-31. Abstract/Full Text
L1 (LINE-1) retrotransposon diversity differs dramatically between mammals and fish.: Furano AV, Duvernell DD, Boissinot S.; Trends Genet (2004 Jan) 20:9-14. Abstract/Full Text
Different rates of LINE-1 (L1) retrotransposon amplification and evolution in New World monkeys.: Boissinot S, Roos C, Furano AV.; J Mol Evol (2004 Jan) 58:122-30. Abstract/Full Text
Fruit flies and humans respond differently to retrotransposons.: Eickbush TH, Furano AV.; Curr Opin Genet Dev (2002 Dec) 12:669-74. Abstract/Full Text
Selection against deleterious LINE-1-containing loci in the human lineage.: Boissinot S, Entezam A, Furano AV.; Mol Biol Evol (2001 Jun) 18:926-35. Abstract/Full Text
L1 (LINE-1) retrotransposon evolution and amplification in recent human history.: Boissinot S, Chevret P, Furano AV.; Mol Biol Evol (2000 Jun) 17:915-28. Abstract/Full Text
The biological properties and evolutionary dynamics of mammalian LINE-1 retrotransposons.: Furano AV.; Prog Nucleic Acid Res Mol Biol (2000) 64:255-94. Abstract/Full Text