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Anthony V. Furano, M.D.
Photo of Anthony Furano.
Section Chief: Genomic Structure and Function Section, Laboratory of Cell and Molecular Biology
Scientific Focus Areas: Cancer Biology, Computational Biology, Genetics and Genomics, Molecular Biology and Biochemistry, Structural Biology
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Publications

A selection of recent and significant publications can be viewed below.

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Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations.
Shen B, Chapman JH, Custance MF, Tricola GM, Jones CE, Furano AV.
Elife (2020 Jan 6) 9. Abstract/Full Text
Cryptic genetic variation enhances primate L1 retrotransposon survival by enlarging the functional coiled coil sequence space of ORF1p.
Furano AV, Jones CE, Periwal V, Callahan KE, Walser JC, Cook PR.
PLoS Genet (2020 Aug) 16:e1008991. Abstract/Full Text
Repair of naturally occurring mismatches can induce mutations in flanking DNA.
Chen J, Miller BF, Furano AV.
Elife (2014 Apr 29) 3:e02001. Abstract/Full Text
L1 retrotransposition requires rapid ORF1p oligomerization, a novel coiled coil-dependent property conserved despite extensive remodeling.
Naufer MN, Callahan KE, Cook PR, Perez-Gonzalez CE, Williams MC, Furano AV.
Nucleic Acids Res (2016 Jan 8) 44:281-93. Abstract/Full Text
Breaking bad: The mutagenic effect of DNA repair.
Chen J, Furano AV.
DNA Repair (Amst) (2015 Aug) 32:43-51. Abstract/Full Text

Additional Publications

The challenge of ORF1p phosphorylation: Effects on L1 activity and its host.
Furano AV, Cook PR.
Mob Genet Elements (2016 Jan-Feb) 6:e1119927. Abstract/Full Text
Polymerization and nucleic acid-binding properties of human L1 ORF1 protein.
Callahan KE, Hickman AB, Jones CE, Ghirlando R, Furano AV.
Nucleic Acids Res (2012 Jan) 40:813-27. Abstract/Full Text
The mutational spectrum of non-CpG DNA varies with CpG content.
Walser JC, Furano AV.
Genome Res (2010 Jul) 20:875-82. Abstract/Full Text
CpG dinucleotides and the mutation rate of non-CpG DNA.
Walser JC, Ponger L, Furano AV.
Genome Res (2008 Sep) 18:1403-14. Abstract/Full Text
Fitness cost of LINE-1 (L1) activity in humans.
Boissinot S, Davis J, Entezam A, Petrov D, Furano AV.
Proc Natl Acad Sci U S A (2006 Jun 20) 103:9590-4. Abstract/Full Text
Human population genetic structure and diversity inferred from polymorphic L1(LINE-1) and Alu insertions.
Witherspoon DJ, Marchani EE, Watkins WS, Ostler CT, Wooding SP, Anders BA, Fowlkes JD, Boissinot S, Furano AV, Ray DA, Rogers AR, Batzer MA, Jorde LB.
Hum Hered (2006) 62:30-46. Abstract/Full Text
The structures of mouse and human L1 elements reflect their insertion mechanism.
Martin SL, Li WL, Furano AV, Boissinot S.
Cytogenet Genome Res (2005) 110:223-8. Abstract/Full Text
The recent evolution of human L1 retrotransposons.
Boissinot S, Furano AV.
Cytogenet Genome Res (2005) 110:402-6. Abstract/Full Text
The insertional history of an active family of L1 retrotransposons in humans.
Boissinot S, Entezam A, Young L, Munson PJ, Furano AV.
Genome Res (2004 Jul) 14:1221-31. Abstract/Full Text
L1 (LINE-1) retrotransposon diversity differs dramatically between mammals and fish.
Furano AV, Duvernell DD, Boissinot S.
Trends Genet (2004 Jan) 20:9-14. Abstract/Full Text
Different rates of LINE-1 (L1) retrotransposon amplification and evolution in New World monkeys.
Boissinot S, Roos C, Furano AV.
J Mol Evol (2004 Jan) 58:122-30. Abstract/Full Text
Fruit flies and humans respond differently to retrotransposons.
Eickbush TH, Furano AV.
Curr Opin Genet Dev (2002 Dec) 12:669-74. Abstract/Full Text
Selection against deleterious LINE-1-containing loci in the human lineage.
Boissinot S, Entezam A, Furano AV.
Mol Biol Evol (2001 Jun) 18:926-35. Abstract/Full Text
L1 (LINE-1) retrotransposon evolution and amplification in recent human history.
Boissinot S, Chevret P, Furano AV.
Mol Biol Evol (2000 Jun) 17:915-28. Abstract/Full Text
The biological properties and evolutionary dynamics of mammalian LINE-1 retrotransposons.
Furano AV.
Prog Nucleic Acid Res Mol Biol (2000) 64:255-94. Abstract/Full Text