Anthony V. Furano, M.D.

Scientific Focus Areas: Cancer Biology, Computational Biology, Genetics and Genomics, Molecular Biology and Biochemistry, Structural Biology
Publications
A selection of recent and significant publications can be viewed below.
Select Publications
- Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations.
- Shen B, Chapman JH, Custance MF, Tricola GM, Jones CE, Furano AV.
- Elife (2020 Jan 6) 9. Abstract/Full Text
- Cryptic genetic variation enhances primate L1 retrotransposon survival by enlarging the functional coiled coil sequence space of ORF1p.
- Furano AV, Jones CE, Periwal V, Callahan KE, Walser JC, Cook PR.
- PLoS Genet (2020 Aug) 16:e1008991. Abstract/Full Text
- Repair of naturally occurring mismatches can induce mutations in flanking DNA.
- Chen J, Miller BF, Furano AV.
- Elife (2014 Apr 29) 3:e02001. Abstract/Full Text
- L1 retrotransposition requires rapid ORF1p oligomerization, a novel coiled coil-dependent property conserved despite extensive remodeling.
- Naufer MN, Callahan KE, Cook PR, Perez-Gonzalez CE, Williams MC, Furano AV.
- Nucleic Acids Res (2016 Jan 8) 44:281-93. Abstract/Full Text
- Breaking bad: The mutagenic effect of DNA repair.
- Chen J, Furano AV.
- DNA Repair (Amst) (2015 Aug) 32:43-51. Abstract/Full Text
Additional Publications
- The challenge of ORF1p phosphorylation: Effects on L1 activity and its host.
- Furano AV, Cook PR.
- Mob Genet Elements (2016 Jan-Feb) 6:e1119927. Abstract/Full Text
- Polymerization and nucleic acid-binding properties of human L1 ORF1 protein.
- Callahan KE, Hickman AB, Jones CE, Ghirlando R, Furano AV.
- Nucleic Acids Res (2012 Jan) 40:813-27. Abstract/Full Text
- The mutational spectrum of non-CpG DNA varies with CpG content.
- Walser JC, Furano AV.
- Genome Res (2010 Jul) 20:875-82. Abstract/Full Text
- CpG dinucleotides and the mutation rate of non-CpG DNA.
- Walser JC, Ponger L, Furano AV.
- Genome Res (2008 Sep) 18:1403-14. Abstract/Full Text
- Fitness cost of LINE-1 (L1) activity in humans.
- Boissinot S, Davis J, Entezam A, Petrov D, Furano AV.
- Proc Natl Acad Sci U S A (2006 Jun 20) 103:9590-4. Abstract/Full Text
- Human population genetic structure and diversity inferred from polymorphic L1(LINE-1) and Alu insertions.
- Witherspoon DJ, Marchani EE, Watkins WS, Ostler CT, Wooding SP, Anders BA, Fowlkes JD, Boissinot S, Furano AV, Ray DA, Rogers AR, Batzer MA, Jorde LB.
- Hum Hered (2006) 62:30-46. Abstract/Full Text
- The structures of mouse and human L1 elements reflect their insertion mechanism.
- Martin SL, Li WL, Furano AV, Boissinot S.
- Cytogenet Genome Res (2005) 110:223-8. Abstract/Full Text
- The recent evolution of human L1 retrotransposons.
- Boissinot S, Furano AV.
- Cytogenet Genome Res (2005) 110:402-6. Abstract/Full Text
- The insertional history of an active family of L1 retrotransposons in humans.
- Boissinot S, Entezam A, Young L, Munson PJ, Furano AV.
- Genome Res (2004 Jul) 14:1221-31. Abstract/Full Text
- L1 (LINE-1) retrotransposon diversity differs dramatically between mammals and fish.
- Furano AV, Duvernell DD, Boissinot S.
- Trends Genet (2004 Jan) 20:9-14. Abstract/Full Text
- Different rates of LINE-1 (L1) retrotransposon amplification and evolution in New World monkeys.
- Boissinot S, Roos C, Furano AV.
- J Mol Evol (2004 Jan) 58:122-30. Abstract/Full Text
- Fruit flies and humans respond differently to retrotransposons.
- Eickbush TH, Furano AV.
- Curr Opin Genet Dev (2002 Dec) 12:669-74. Abstract/Full Text
- Selection against deleterious LINE-1-containing loci in the human lineage.
- Boissinot S, Entezam A, Furano AV.
- Mol Biol Evol (2001 Jun) 18:926-35. Abstract/Full Text
- L1 (LINE-1) retrotransposon evolution and amplification in recent human history.
- Boissinot S, Chevret P, Furano AV.
- Mol Biol Evol (2000 Jun) 17:915-28. Abstract/Full Text
- The biological properties and evolutionary dynamics of mammalian LINE-1 retrotransposons.
- Furano AV.
- Prog Nucleic Acid Res Mol Biol (2000) 64:255-94. Abstract/Full Text