Marvin C. Gershengorn, M.D.

• Chief: Laboratory of Endocrinology & Receptor Biology
• Section Chief: Receptor and Hormone Action Section, Laboratory of Endocrinology & Receptor Biology

Scientific Focus Areas: Cell Biology, Molecular Pharmacology

marvin.gershengorn@nih.gov 301-451-6305 Add to Contacts

Publications

A selection of recent and significant publications can be viewed below.

Select Publications

TSH/IGF1 receptor crosstalk: Mechanism and clinical implications.

Krieger CC, Neumann S, Gershengorn MC.

Pharmacol Ther (2020 May) 209:107502. Abstract/Full Text

Arrestin-β-1 Physically Scaffolds TSH and IGF1 Receptors to Enable Crosstalk.

Krieger CC, Boutin A, Jang D, Morgan SJ, Banga JP, Kahaly GJ, Klubo-Gwiezdzinska J, Neumann S, Gershengorn MC.

Endocrinology (2019 Jun 1) 160:1468-1479. Abstract/Full Text

Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro.

Neumann S, Eliseeva E, Boutin A, Barnaeva E, Ferrer M, Southall N, Kim D, Hu X, Morgan SJ, Marugan JJ, Gershengorn MC.

J Pharmacol Exp Ther (2018 Jan) 364:38-45. Abstract/Full Text

Evidence That Graves' Ophthalmopathy Immunoglobulins Do Not Directly Activate IGF-1 Receptors.

Marcus-Samuels B, Krieger CC, Boutin A, Kahaly GJ, Neumann S, Gershengorn MC.

Thyroid (2018 May) 28:650-655. Abstract/Full Text

Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue.

Dougherty JP, Wolff BS, Cullen MJ, Saligan LN, Gershengorn MC.

Pharmacol Res (2017 Oct) 124:1-8. Abstract/Full Text

Additional Publications

Thyrotropin, but Not Thyroid-Stimulating Antibodies, Induces Biphasic Regulation of Gene Expression in Human Thyrocytes.

Jang D, Morgan SJ, Klubo-Gwiezdzinska J, Banga JP, Neumann S, Gershengorn MC.

Thyroid (2020 Feb) 30:270-276. Abstract/Full Text

Thyrotropin Causes Dose-dependent Biphasic Regulation of cAMP Production Mediated by G(s) and G(i/o) Proteins.

Neumann S, Malik SS, Marcus-Samuels B, Eliseeva E, Jang D, Klubo-Gwiezdzinska J, Krieger CC, Gershengorn MC.

Mol Pharmacol (2020 Jan) 97:2-8. Abstract/Full Text

Normal Human Thyrocytes in Culture.

Morgan SJ, Neumann S, Gershengorn MC.

Methods Mol Biol (2018) 1817:1-7. Abstract/Full Text

Rebuttal to Smith and Janssen (Thyroid 2017;27:746-747. DOI: 10.1089/thy.2017.0281).

Neumann S, Gershengorn MC.

Thyroid (2017 Nov) 27:1459-1460. Abstract/Full Text

TSH/IGF-1 Receptor Cross-Talk Rapidly Activates Extracellular Signal-Regulated Kinases in Multiple Cell Types.

Krieger CC, Perry JD, Morgan SJ, Kahaly GJ, Gershengorn MC.

Endocrinology (2017 Oct 1) 158:3676-3683. Abstract/Full Text

TSHR/IGF-1R Cross-Talk, Not IGF-1R Stimulating Antibodies, Mediates Graves' Ophthalmopathy Pathogenesis.

Krieger CC, Neumann S, Marcus-Samuels B, Gershengorn MC.

Thyroid (2017 May) 27:746-747. Abstract/Full Text

Inhibiting thyrotropin/insulin-like growth factor 1 receptor crosstalk to treat Graves' ophthalmopathy: studies in orbital fibroblasts in vitro.

Place RF, Krieger CC, Neumann S, Gershengorn MC.

Br J Pharmacol (2017 Feb) 174:328-340. Abstract/Full Text

Thyrotropin and Insulin-Like Growth Factor 1 Receptor Crosstalk Upregulates Sodium-Iodide Symporter Expression in Primary Cultures of Human Thyrocytes.

Morgan SJ, Neumann S, Marcus-Samuels B, Gershengorn MC.

Thyroid (2016 Dec) 26:1794-1803. Abstract/Full Text

TSH/IGF-1 Receptor Cross Talk in Graves' Ophthalmopathy Pathogenesis.

Krieger CC, Place RF, Bevilacqua C, Marcus-Samuels B, Abel BS, Skarulis MC, Kahaly GJ, Neumann S, Gershengorn MC.

J Clin Endocrinol Metab (2016 Jun) 101:2340-7. Abstract/Full Text

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse.

Dougherty JP, Springer DA, Gershengorn MC.

J Vis Exp (2016 May 31) Abstract/Full Text