Research Materials
Patents, materials, and other research resources appear below. Some resources may be available for use through Material Transfer Agreements (MTAs) or licensing agreements.
-
Adenovirus gene expression system (U.S. Patent Number 6,824,770)
The invention is directed to an adenoviral vector comprising (a) at least one insertion site for cloning a heterologous gene, and, in an orientation opposite to the direction of transcription of the adenoviral region into which it is inserted, (b) a… -
Inverse agonists & neutral antagonists for the tsh receptor (U.S. Patent Application Number WO 2011127388 A2)
TSHR inverse agonists and neutral antagonists that are useful for treating Graves' orbitopathy, Graves' hyperthyroidism and/or thyroid cancer -
Low molecular weight thyroid stimulating hormone receptor (tshr) agonists (U.S. Patent Application Number WO 2010047674 A1)
NIH investigators have discovered a series of low molecular weight thyroid-stimulating hormone (TSH) receptor modulators for use in the procedure to detect residual thyroid cancer cells following thyroidectomy. As small molecules, these compounds are… -
Methods of identifying negative antagonists for G protein coupled receptors (U.S. Patent Number 6,087,115)
The present invention is directed to a constitutively active G protein coupled receptor of human herpesvirus 8, as well as a method of identifying negative antagonists of a constitutively active G protein coupled receptor. The method comprises… -
Methods of identifying peptide agonists or negative antagonists of a G protein coupled receptor (U.S. Patent Number 6,403,305)
The present invention is directed to a strategy to discover small peptides that will activate any G protein coupled receptor (GPCR) or inactivate any constitutively active GPCR. The strategy uses combinatorial peptide libraries to screen millions of… -
Pituitary TRH receptor (U.S. Patent Number 5,288,621)
Disclosed for the first time is the isolation, sequence, and expression cloning of a cDNA encoding for pituitary thyrotropin-releasing hormone receptor, as well as the amino acid sequence for the receptor per se -
Receptors that regulate cell signaling relating to chemokines (U.S. Patent Number 6,365,356)
A method for discovering molecules that regulate cell signaling specific to the dual presence of Duffy antigen receptor for chemokines (DARC) and a chemokine receptor selected from the group consisting of a CXC receptor, a CC receptor and a CXXXC…