Phillip Gorden, M.D., Director Emeritus


A selection of recent and significant publications can be viewed below.

Select Publications

Syndromic insulin resistance: models for the therapeutic basis of the metabolic syndrome and other targets of insulin resistance.
Gorden P, Zadeh ES, Cochran E, Brown RJ.
Endocr Pract (2012 Sep-Oct) 18:763-71. Abstract/Full Text
Insulin resistance is a sufficient basis for hyperandrogenism in lipodystrophic women with polycystic ovarian syndrome.
Lungu AO, Zadeh ES, Goodling A, Cochran E, Gorden P.
J Clin Endocrinol Metab (2012 Feb) 97:563-7. Abstract/Full Text
Clinical effects of long-term metreleptin treatment in patients with lipodystrophy.
Chan JL, Lutz K, Cochran E, Huang W, Peters Y, Weyer C, Gorden P.
Endocr Pract (2011 Nov-Dec) 17:922-32. Abstract/Full Text
Genetic syndromes of severe insulin resistance.
Semple RK, Savage DB, Cochran EK, Gorden P, O'Rahilly S.
Endocr Rev (2011 Aug) 32:498-514. Abstract/Full Text
Treatment of type B insulin resistance: a novel approach to reduce insulin receptor autoantibodies.
Malek R, Chong AY, Lupsa BC, Lungu AO, Cochran EK, Soos MA, Semple RK, Balow JE, Gorden P.
J Clin Endocrinol Metab (2010 Aug) 95:3641-7. Abstract/Full Text

Additional Publications

Combined Immunosuppressive Therapy Induces Remission in Patients With Severe Type B Insulin Resistance: A Prospective Cohort Study.
Klubo-Gwiezdzinska J, Lange M, Cochran E, Semple RK, Gewert C, Brown RJ, Gorden P.
Diabetes Care (2018 Nov) 41:2353-2360. Abstract/Full Text
Incidence and management of postoperative hyperglycemia in patients undergoing insulinoma resection.
Nockel P, Tirosh A, El Lakis M, Gaitanidis A, Merkel R, Patel D, Nilubol N, Sadowski SM, Cochran C, Gorden P, Kebebew E.
Endocrine (2018 Sep) 61:422-427. Abstract/Full Text
Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy.
Brown RJ, Valencia A, Startzell M, Cochran E, Walter PJ, Garraffo HM, Cai H, Gharib AM, Ouwerkerk R, Courville AB, Bernstein S, Brychta RJ, Chen KY, Walter M, Auh S, Gorden P.
J Clin Invest (2018 Aug 1) 128:3504-3516. Abstract/Full Text
Localization of Insulinoma Using 68Ga-DOTATATE PET/CT Scan.
Nockel P, Babic B, Millo C, Herscovitch P, Patel D, Nilubol N, Sadowski SM, Cochran C, Gorden P, Kebebew E.
J Clin Endocrinol Metab (2017 Jan 1) 102:195-199. Abstract/Full Text
Insulinoma Due to Multiple Pancreatic Microadenoma Localized by Multimodal Imaging.
Babic B, Keutgen X, Nockel P, Miettinen M, Millo C, Herscovitch P, Patel D, Nilubol N, Cochran C, Gorden P, Kebebew E.
J Clin Endocrinol Metab (2016 Oct) 101:3559-3563. Abstract/Full Text
JCL roundtable: Diagnosis and clinical management of lipodystrophy.
Brown WV, Garg A, Gorden P, Shamburek R.
J Clin Lipidol (2016 Jul-Aug) 10:728-736. Abstract/Full Text
Lipid regulation in lipodystrophy versus the obesity-associated metabolic syndrome: the dissociation of HDL-C and triglycerides.
Joseph J, Shamburek RD, Cochran EK, Gorden P, Brown RJ.
J Clin Endocrinol Metab (2014 Sep) 99:E1676-80. Abstract/Full Text
Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease.
Payne F, Lim K, Girousse A, Brown RJ, Kory N, Robbins A, Xue Y, Sleigh A, Cochran E, Adams C, Dev Borman A, Russel-Jones D, Gorden P, Semple RK, Saudek V, O'Rahilly S, Walther TC, Barroso I, Savage DB.
Proc Natl Acad Sci U S A (2014 Jun 17) 111:8901-6. Abstract/Full Text
Effects of leptin replacement therapy on pancreatic β-cell function in patients with lipodystrophy.
Muniyappa R, Brown RJ, Mari A, Joseph J, Warren MA, Cochran EK, Skarulis MC, Gorden P.
Diabetes Care (2014 Apr) 37:1101-7. Abstract/Full Text
Insulin Receptor and the Kidney: Nephrocalcinosis in Patients with Recessive INSR Mutations.
Simpkin A, Cochran E, Cameron F, Dattani M, de Bock M, Dunger DB, Forsander G, Guran T, Harris J, Isaac I, Hussain K, Kleta R, Peters C, Tasic V, Williams R, Yap Kok Peng F, O''Rahilly S, Gorden P, Semple RK, Bockenhauer D.
Nephron Physiol (2014) 128:55-61. Abstract/Full Text
Ectopic growth hormone-releasing hormone secretion by a bronchial carcinoid tumor: clinical experience following tumor resection and long-acting octreotide therapy.
Butler PW, Cochran CS, Merino MJ, Nguyen DM, Schrump DS, Gorden P.
Pituitary (2012 Jun) 15:260-5. Abstract/Full Text
Pregnancy in a woman with congenital generalized lipodystrophy: leptin's vital role in reproduction.
Maguire M, Lungu A, Gorden P, Cochran E, Stratton P.
Obstet Gynecol (2012 Feb) 119:452-5. Abstract/Full Text
Consequences of stopping and restarting leptin in an adolescent with lipodystrophy.
Kamran F, Rother KI, Cochran E, Safar Zadeh E, Gorden P, Brown RJ.
Horm Res Paediatr (2012) 78:320-5. Abstract/Full Text
Founder effect in the Horn of Africa for an insulin receptor mutation that may impair receptor recycling.
Raffan E, Soos MA, Rocha N, Tuthill A, Thomsen AR, Hyden CS, Gregory JW, Hindmarsh P, Dattani M, Cochran E, Al Kaabi J, Gorden P, Barroso I, Morling N, O'Rahilly S, Semple RK.
Diabetologia (2011 May) 54:1057-65. Abstract/Full Text
Is there a human model for the 'metabolic syndrome' with a defined aetiology?
Gorden P, Lupsa BC, Chong AY, Lungu AO.
Diabetologia (2010 Jul) 53:1534-6. Abstract/Full Text
Deletion of 8q24 in an adult with mild dysmorphic features, developmental delay, and ketotic hypoglycemia.
Solomon BD, Lange E, Shubrook J, Service FJ, Herman G, Karne RJ, Gorden P, Muenke M, Stratakis CA.
Am J Med Genet A (2010 Jun) 152A:1545-9. Abstract/Full Text
Insulin secretion and insulin-producing tumors.
Guettier JM, Gorden P.
Expert Rev Endocrinol Metab (2010 Mar 1) 5:217-227. Abstract/Full Text
Insulinoma: pathophysiology, localization and management.
Shin JJ, Gorden P, Libutti SK.
Future Oncol (2010 Feb) 6:229-37. Abstract/Full Text
Mathur A, Gorden P, Libutti SK.
Surg Clin North Am (2009 Oct) 89:1105-21. Abstract/Full Text
Autoimmune forms of hypoglycemia.
Lupsa BC, Chong AY, Cochran EK, Soos MA, Semple RK, Gorden P.
Medicine (Baltimore) (2009 May) 88:141-53. Abstract/Full Text
Localization of insulinomas to regions of the pancreas by intraarterial calcium stimulation: the NIH experience.
Guettier JM, Kam A, Chang R, Skarulis MC, Cochran C, Alexander HR, Libutti SK, Pingpank JF, Gorden P.
J Clin Endocrinol Metab (2009 Apr) 94:1074-80. Abstract/Full Text
Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis.
Semple RK, Sleigh A, Murgatroyd PR, Adams CA, Bluck L, Jackson S, Vottero A, Kanabar D, Charlton-Menys V, Durrington P, Soos MA, Carpenter TA, Lomas DJ, Cochran EK, Gorden P, O'Rahilly S, Savage DB.
J Clin Invest (2009 Feb) 119:315-22. Abstract/Full Text
Complement abnormalities in acquired lipodystrophy revisited.
Savage DB, Semple RK, Clatworthy MR, Lyons PA, Morgan BP, Cochran EK, Gorden P, Raymond-Barker P, Murgatroyd PR, Adams C, Scobie I, Mufti GJ, Alexander GJ, Thiru S, Murano I, Cinti S, Chaudhry AN, Smith KG, O'Rahilly S.
J Clin Endocrinol Metab (2009 Jan) 94:10-6. Abstract/Full Text
Effect of depot medroxyprogesterone acetate on glucose tolerance in generalized lipodystrophy.
Yauger BJ, Gorden P, Park J, Cochran E, Stratton P.
Obstet Gynecol (2008 Aug) 112:445-7. Abstract/Full Text
Plasma adiponectin as a marker of insulin receptor dysfunction: clinical utility in severe insulin resistance.
Semple RK, Cochran EK, Soos MA, Burling KA, Savage DB, Gorden P, O'Rahilly S.
Diabetes Care (2008 May) 31:977-9. Abstract/Full Text
Leptin therapy for partial lipodystrophy linked to a PPAR-gamma mutation.
Guettier JM, Park JY, Cochran EK, Poitou C, Basdevant A, Meier M, Clément K, Magré J, Gorden P.
Clin Endocrinol (Oxf) (2008 Apr) 68:547-554. Abstract/Full Text
Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor.
Lodish MB, Powell AC, Abu-Asab M, Cochran C, Lenz P, Libutti SK, Pingpank JF, Tsokos M, Gorden P.
J Clin Endocrinol Metab (2008 Apr) 93:1123-8. Abstract/Full Text
Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: the effect of long-term leptin therapy.
Park JY, Chong AY, Cochran EK, Kleiner DE, Haller MJ, Schatz DA, Gorden P.
J Clin Endocrinol Metab (2008 Jan) 93:26-31. Abstract/Full Text
Paradoxical elevation of high-molecular weight adiponectin in acquired extreme insulin resistance due to insulin receptor antibodies.
Semple RK, Halberg NH, Burling K, Soos MA, Schraw T, Luan J, Cochran EK, Dunger DB, Wareham NJ, Scherer PE, Gorden P, O'Rahilly S.
Diabetes (2007 Jun) 56:1712-7. Abstract/Full Text
Long-term efficacy of leptin replacement in patients with Dunnigan-type familial partial lipodystrophy.
Park JY, Javor ED, Cochran EK, DePaoli AM, Gorden P.
Metabolism (2007 Apr) 56:508-16. Abstract/Full Text
Guettier JM, Gorden P.
Endocrinol Metab Clin North Am (2006 Dec) 35:753-66, viii-ix. Abstract/Full Text
Elevated plasma adiponectin in humans with genetically defective insulin receptors.
Semple RK, Soos MA, Luan J, Mitchell CS, Wilson JC, Gurnell M, Cochran EK, Gorden P, Chatterjee VK, Wareham NJ, O'Rahilly S.
J Clin Endocrinol Metab (2006 Aug) 91:3219-23. Abstract/Full Text
Spectrum of renal diseases associated with extreme forms of insulin resistance.
Musso C, Javor E, Cochran E, Balow JE, Gorden P.
Clin J Am Soc Nephrol (2006 Jul) 1:616-22. Abstract/Full Text
The clinical utility of leptin therapy in metabolic dysfunction.
Park JY, Gavrilova O, Gorden P.
Minerva Endocrinol (2006 Jun) 31:125-31. Abstract/Full Text
The clinical efficacy of the adipocyte-derived hormone leptin in metabolic dysfunction.
Gorden P, Park JY.
Arch Physiol Biochem (2006 Apr) 112:114-8. Abstract/Full Text
Leptin replacement therapy modulates circulating lymphocyte subsets and cytokine responsiveness in severe lipodystrophy.
Oral EA, Javor ED, Ding L, Uzel G, Cochran EK, Young JR, DePaoli AM, Holland SM, Gorden P.
J Clin Endocrinol Metab (2006 Feb) 91:621-8. Abstract/Full Text
A prospective evaluation of laparoscopic exploration with intraoperative ultrasound as a technique for localizing sporadic insulinomas.
Grover AC, Skarulis M, Alexander HR, Pingpank JF, Javor ED, Chang R, Shawker T, Gorden P, Cochran C, Libutti SK.
Surgery (2005 Dec) 138:1003-8; discussion 1008. Abstract/Full Text
Malignant insulinoma: spectrum of unusual clinical features.
Hirshberg B, Cochran C, Skarulis MC, Libutti SK, Alexander HR, Wood BJ, Chang R, Kleiner DE, Gorden P.
Cancer (2005 Jul 15) 104:264-72. Abstract/Full Text
Clinical evidence that hyperinsulinaemia independent of gonadotropins stimulates ovarian growth.
Musso C, Shawker T, Cochran E, Javor ED, Young J, Gorden P.
Clin Endocrinol (Oxf) (2005 Jul) 63:73-8. Abstract/Full Text
Long-term efficacy of leptin replacement in patients with generalized lipodystrophy.
Javor ED, Cochran EK, Musso C, Young JR, Depaoli AM, Gorden P.
Diabetes (2005 Jul) 54:1994-2002. Abstract/Full Text
The impact of evidence-based medicine on diabetes therapy.
Gorden P, Musso C.
Curr Diab Rep (2005 Jun) 5:157-9. Abstract/Full Text
The use of U-500 in patients with extreme insulin resistance.
Cochran E, Musso C, Gorden P.
Diabetes Care (2005 May) 28:1240-4. Abstract/Full Text
Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy.
Javor ED, Ghany MG, Cochran EK, Oral EA, DePaoli AM, Premkumar A, Kleiner DE, Gorden P.
Hepatology (2005 Apr) 41:753-60. Abstract/Full Text
The long-term effect of recombinant methionyl human leptin therapy on hyperandrogenism and menstrual function in female and pituitary function in male and female hypoleptinemic lipodystrophic patients.
Musso C, Cochran E, Javor E, Young J, Depaoli AM, Gorden P.
Metabolism (2005 Feb) 54:255-63. Abstract/Full Text
Changes in body composition in patients with severe lipodystrophy after leptin replacement therapy.
Moran SA, Patten N, Young JR, Cochran E, Sebring N, Reynolds J, Premkumar A, Depaoli AM, Skarulis MC, Oral EA, Gorden P.
Metabolism (2004 Apr) 53:513-9. Abstract/Full Text