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Deborah Hoshizaki, Ph.D.

Photo of Deborah Hoshizaki
Kidney and Urogenital Development; Kidney and Urology Regeneration and Repair; Urology Centers

Responsibilities & Activities

As director of kidney and urology programs in the areas of developmental biology, regeneration, and aging, I am responsible for administering a grant portfolio on basic cellular, molecular, and genetics of normal development, maturation, and aging of the kidney and lower urinary tract and associated systems, including the immune system, vasculature, and nervous system. Also included are studies on the basic science of normal repair and the progression to maladaptive repair and regeneration of the kidney and organs of the lower urinary tract (bladder, prostate, etc.) and associated systems.

My interests lie in studies that focus on:

  1. Fundamental developmental mechanisms of the kidney and lower urinary tract organs, especially innervation, angiogenesis, and the population of said organs with immune cells
  2. Tissue differentiation leading to physiological function and environmental interactions that lead to congenital abnormalities or alterations in physiological capacity
  3. Cellular response to injury or aging and the transition from normal repair to maladaptive repair, and the regeneration processes that include re-establishment of the vasculature and innervation and repopulation of immune cells

I direct several consortia: the Urology Research Centers program; the GenitoUrinary Development Molecular Anatomy Project (GUDMAP) which facilitates research in the murine and human urinary tract development through the assembly of a molecular atlas of the developing kidney, bladder, and prostate; Rebuilding a Kidney Consortium, which is informing the best strategies for generating nephrons for clinical use.

Research Programs

Kidney Basic Research
The mechanisms and pathophysiology underlying renal disease and its progression.

Kidney Bioengineering, Biotechnology, & Imaging
The development of new technologies for the diagnosis, monitoring, or treatment of renal disease.

Kidney Developmental Biology & Aging
Research on the developing and aging kidney.

Pediatric Kidney Disease
Interventional, epidemiological, descriptive, or natural history studies of children with acute or chronic renal diseases.

Pediatric Urology
Interventional, epidemiological, descriptive, and natural history studies of children with noncancerous urologic disease.

Urology Basic Research
The mechanisms and pathophysiology underlying noncancerous urologic disease and its progression.

Urology Bioengineering, Biotechnology, & Imaging
The development of new technologies for the diagnosis, monitoring, or treatment of noncancerous urologic disease

Urology Developmental Biology & Aging
Research on the developing and aging lower genitourinary tract.

Urology Genetics & Genomics
Genetics and genomics approaches to elucidate the normal and pathologic functions of the lower genitourinary tract.