William Prinz, Ph.D.

Section Chief:
Lipid Trafficking and Organelle Biogenesis Section, Laboratory of Cell and Molecular Biology
Scientific Focus Areas: Cell Biology, Molecular Biology and Biochemistry
Publications
A selection of recent and significant publications can be viewed below.
Select Publications
- Architecture of Lipid Droplets in Endoplasmic Reticulum Is Determined by Phospholipid Intrinsic Curvature.
- Choudhary V, Golani G, Joshi AS, Cottier S, Schneiter R, Prinz WA, Kozlov MM.
- Curr Biol (2018 Mar 19) 28:915-926.e9. Abstract/Full Text
- Lipid droplet and peroxisome biogenesis occur at the same ER subdomains.
- Joshi AS, Nebenfuehr B, Choudhary V, Satpute-Krishnan P, Levine TP, Golden A, Prinz WA.
- Nat Commun (2018 Jul 27) 9:2940. Abstract/Full Text
- An inducible ER-Golgi tether facilitates ceramide transport to alleviate lipotoxicity.
- Liu LK, Choudhary V, Toulmay A, Prinz WA.
- J Cell Biol (2017 Jan 2) 216:131-147. Abstract/Full Text
- A family of membrane-shaping proteins at ER subdomains regulates pre-peroxisomal vesicle biogenesis.
- Joshi AS, Huang X, Choudhary V, Levine TP, Hu J, Prinz WA.
- J Cell Biol (2016 Nov 21) 215:515-529. Abstract/Full Text
- Direct imaging reveals stable, micrometer-scale lipid domains that segregate proteins in live cells.
- Toulmay A, Prinz WA.
- J Cell Biol (2013 Jul 8) 202:35-44. Abstract/Full Text
Additional Publications
- Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER.
- Friedman JR, Kannan M, Toulmay A, Jan CH, Weissman JS, Prinz WA, Nunnari J.
- Dev Cell (2018 Jan 22) 44:261-270.e6. Abstract/Full Text
- Fat storage-inducing transmembrane (FIT or FITM) proteins are related to lipid phosphatase/phosphotransferase enzymes.
- Hayes M, Choudhary V, Ojha N, Shin JJ, Han GS, Carman GM, Loewen CJ, Prinz WA, Levine T.
- Microb Cell (2017 Dec 28) 5:88-103. Abstract/Full Text
- A cholesterol-sensing mechanism unfolds.
- Prinz WA.
- J Biol Chem (2017 Dec 8) 292:19974-19975. Abstract/Full Text
- Sequences flanking the transmembrane segments facilitate mitochondrial localization and membrane fusion by mitofusin.
- Huang X, Zhou X, Hu X, Joshi AS, Guo X, Zhu Y, Chen Q, Prinz WA, Hu J.
- Proc Natl Acad Sci U S A (2017 Nov 14) 114:E9863-E9872. Abstract/Full Text
- Sterol transporters at membrane contact sites regulate TORC1 and TORC2 signaling.
- Murley A, Yamada J, Niles BJ, Toulmay A, Prinz WA, Powers T, Nunnari J.
- J Cell Biol (2017 Sep 4) 216:2679-2689. Abstract/Full Text
- Organelle biogenesis in the endoplasmic reticulum.
- Joshi AS, Zhang H, Prinz WA.
- Nat Cell Biol (2017 Aug) 19:876-882. Abstract/Full Text
- Phosphatidylserine synthesis at membrane contact sites promotes its transport out of the ER.
- Kannan M, Lahiri S, Liu LK, Choudhary V, Prinz WA.
- J Lipid Res (2017 Mar) 58:553-562. Abstract/Full Text
- Glycerolipid synthesis and lipid trafficking in plant mitochondria.
- Michaud M, Prinz WA, Jouhet J.
- FEBS J (2017 Feb) 284:376-390. Abstract/Full Text
- Endoplasmic reticulum stress affects the transport of phosphatidylethanolamine from mitochondria to the endoplasmic reticulum in S.cerevisiae.
- Kannan M, Sivaprakasam C, Prinz WA, Nachiappan V.
- Biochim Biophys Acta (2016 Dec) 1861:1959-1967. Abstract/Full Text
- Keeping FIT, storing fat: Lipid droplet biogenesis.
- Choudhary V, Golden A, Prinz WA.
- Worm (2016 Apr-Jun) 5:e1170276. Abstract/Full Text
- AtMic60 Is Involved in Plant Mitochondria Lipid Trafficking and Is Part of a Large Complex.
- Michaud M, Gros V, Tardif M, Brugière S, Ferro M, Prinz WA, Toulmay A, Mathur J, Wozny M, Falconet D, Maréchal E, Block MA, Jouhet J.
- Curr Biol (2016 Mar 7) 26:627-39. Abstract/Full Text
- A conserved family of proteins facilitates nascent lipid droplet budding from the ER.
- Choudhary V, Ojha N, Golden A, Prinz WA.
- J Cell Biol (2015 Oct 26) 211:261-71. Abstract/Full Text
- Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts.
- Murley A, Sarsam RD, Toulmay A, Yamada J, Prinz WA, Nunnari J.
- J Cell Biol (2015 May 25) 209:539-48. Abstract/Full Text
- Membrane contact sites, gateways for lipid homeostasis.
- Lahiri S, Toulmay A, Prinz WA.
- Curr Opin Cell Biol (2015 Apr) 33:82-87. Abstract/Full Text
- A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria.
- Lahiri S, Chao JT, Tavassoli S, Wong AK, Choudhary V, Young BP, Loewen CJ, Prinz WA.
- PLoS Biol (2014 Oct) 12:e1001969. Abstract/Full Text
- Editorial overview: Cell organelles.
- Banfield DK, Prinz W.
- Curr Opin Cell Biol (2014 Aug) 29:v-vi. Abstract/Full Text
- Bridging the gap: membrane contact sites in signaling, metabolism, and organelle dynamics.
- Prinz WA.
- J Cell Biol (2014 Jun 23) 205:759-69. Abstract/Full Text
- The lipid trade.
- Prinz WA.
- Nat Rev Mol Cell Biol (2014 Feb) 15:79. Abstract/Full Text
- Plasma membrane--endoplasmic reticulum contact sites regulate phosphatidylcholine synthesis.
- Tavassoli S, Chao JT, Young BP, Cox RC, Prinz WA, de Kroon AI, Loewen CJ.
- EMBO Rep (2013 May) 14:434-40. Abstract/Full Text
- A bridge to understanding lipid droplet growth.
- Prinz WA.
- Dev Cell (2013 Feb 25) 24:335-6. Abstract/Full Text
- ER-shaping proteins facilitate lipid exchange between the ER and mitochondria in S. cerevisiae.
- Voss C, Lahiri S, Young BP, Loewen CJ, Prinz WA.
- J Cell Sci (2012 Oct 15) 125:4791-9. Abstract/Full Text
- Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion.
- Liu TY, Bian X, Sun S, Hu X, Klemm RW, Prinz WA, Rapoport TA, Hu J.
- Proc Natl Acad Sci U S A (2012 Aug 7) 109:E2146-54. Abstract/Full Text
- The budding yeast nuclear envelope adjacent to the nucleolus serves as a membrane sink during mitotic delay.
- Witkin KL, Chong Y, Shao S, Webster MT, Lahiri S, Walters AD, Lee B, Koh JL, Prinz WA, Andrews BJ, Cohen-Fix O.
- Curr Biol (2012 Jun 19) 22:1128-33. Abstract/Full Text
- The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae.
- Anwar K, Klemm RW, Condon A, Severin KN, Zhang M, Ghirlando R, Hu J, Rapoport TA, Prinz WA.
- J Cell Biol (2012 Apr 16) 197:209-17. Abstract/Full Text
- A conserved membrane-binding domain targets proteins to organelle contact sites.
- Toulmay A, Prinz WA.
- J Cell Sci (2012 Jan 1) 125:49-58. Abstract/Full Text
- Weaving the web of ER tubules.
- Hu J, Prinz WA, Rapoport TA.
- Cell (2011 Dec 9) 147:1226-31. Abstract/Full Text
- Lipid transfer and signaling at organelle contact sites: the tip of the iceberg.
- Toulmay A, Prinz WA.
- Curr Opin Cell Biol (2011 Aug) 23:458-63. Abstract/Full Text
- A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking.
- Du X, Kumar J, Ferguson C, Schulz TA, Ong YS, Hong W, Prinz WA, Parton RG, Brown AJ, Yang H.
- J Cell Biol (2011 Jan 10) 192:121-35. Abstract/Full Text
- Lipid trafficking sans vesicles: where, why, how?
- Prinz WA.
- Cell (2010 Dec 10) 143:870-4. Abstract/Full Text
- Mechanisms determining the morphology of the peripheral ER.
- Shibata Y, Shemesh T, Prinz WA, Palazzo AF, Kozlov MM, Rapoport TA.
- Cell (2010 Nov 24) 143:774-88. Abstract/Full Text
- Metabolic response to iron deficiency in Saccharomyces cerevisiae.
- Shakoury-Elizeh M, Protchenko O, Berger A, Cox J, Gable K, Dunn TM, Prinz WA, Bard M, Philpott CC.
- J Biol Chem (2010 May 7) 285:14823-33. Abstract/Full Text
- The diverse functions of oxysterol-binding proteins.
- Raychaudhuri S, Prinz WA.
- Annu Rev Cell Dev Biol (2010) 26:157-77. Abstract/Full Text
- Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues.
- Schulz TA, Choi MG, Raychaudhuri S, Mears JA, Ghirlando R, Hinshaw JE, Prinz WA.
- J Cell Biol (2009 Dec 14) 187:889-903. Abstract/Full Text
- Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response.
- Schuck S, Prinz WA, Thorn KS, Voss C, Walter P.
- J Cell Biol (2009 Nov 16) 187:525-36. Abstract/Full Text
- Membrane-bending proteins.
- Prinz WA, Hinshaw JE.
- Crit Rev Biochem Mol Biol (2009 Sep-Oct) 44:278-91. Abstract/Full Text
- A class of dynamin-like GTPases involved in the generation of the tubular ER network.
- Hu J, Shibata Y, Zhu PP, Voss C, Rismanchi N, Prinz WA, Rapoport TA, Blackstone C.
- Cell (2009 Aug 7) 138:549-61. Abstract/Full Text
- Control of protein and sterol trafficking by antagonistic activities of a type IV P-type ATPase and oxysterol binding protein homologue.
- Muthusamy BP, Raychaudhuri S, Natarajan P, Abe F, Liu K, Prinz WA, Graham TR.
- Mol Biol Cell (2009 Jun) 20:2920-31. Abstract/Full Text
- Calmodulin-driven nuclear entry: trigger for sex determination and terminal differentiation.
- Hanover JA, Love DC, Prinz WA.
- J Biol Chem (2009 May 8) 284:12593-7. Abstract/Full Text
- Nonvesicular phospholipid transfer between peroxisomes and the endoplasmic reticulum.
- Raychaudhuri S, Prinz WA.
- Proc Natl Acad Sci U S A (2008 Oct 14) 105:15785-90. Abstract/Full Text
- Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae.
- Federovitch CM, Jones YZ, Tong AH, Boone C, Prinz WA, Hampton RY.
- Mol Biol Cell (2008 Oct) 19:4506-20. Abstract/Full Text
- The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum.
- Shibata Y, Voss C, Rist JM, Hu J, Rapoport TA, Prinz WA, Voeltz GK.
- J Biol Chem (2008 Jul 4) 283:18892-904. Abstract/Full Text
- Dynamics of cholesterol exchange in the oxysterol binding protein family.
- Canagarajah BJ, Hummer G, Prinz WA, Hurley JH.
- J Mol Biol (2008 May 2) 378:737-48. Abstract/Full Text
- Membrane proteins of the endoplasmic reticulum induce high-curvature tubules.
- Hu J, Shibata Y, Voss C, Shemesh T, Li Z, Coughlin M, Kozlov MM, Rapoport TA, Prinz WA.
- Science (2008 Feb 29) 319:1247-50. Abstract/Full Text
- Sterol transport in yeast and the oxysterol binding protein homologue (OSH) family.
- Schulz TA, Prinz WA.
- Biochim Biophys Acta (2007 Jun) 1771:769-80. Abstract/Full Text
- Sheets, ribbons and tubules - how organelles get their shape.
- Voeltz GK, Prinz WA.
- Nat Rev Mol Cell Biol (2007 Mar) 8:258-64. Abstract/Full Text