William Prinz, Ph.D.

Publications

A selection of recent and significant publications can be viewed below.

Select Publications

Architecture of Lipid Droplets in Endoplasmic Reticulum Is Determined by Phospholipid Intrinsic Curvature.
Choudhary V, Golani G, Joshi AS, Cottier S, Schneiter R, Prinz WA, Kozlov MM.
Curr Biol (2018 Mar 19) 28:915-926.e9. Abstract/Full Text
Lipid droplet and peroxisome biogenesis occur at the same ER subdomains.
Joshi AS, Nebenfuehr B, Choudhary V, Satpute-Krishnan P, Levine TP, Golden A, Prinz WA.
Nat Commun (2018 Jul 27) 9:2940. Abstract/Full Text
An inducible ER-Golgi tether facilitates ceramide transport to alleviate lipotoxicity.
Liu LK, Choudhary V, Toulmay A, Prinz WA.
J Cell Biol (2017 Jan 2) 216:131-147. Abstract/Full Text
A family of membrane-shaping proteins at ER subdomains regulates pre-peroxisomal vesicle biogenesis.
Joshi AS, Huang X, Choudhary V, Levine TP, Hu J, Prinz WA.
J Cell Biol (2016 Nov 21) 215:515-529. Abstract/Full Text
Direct imaging reveals stable, micrometer-scale lipid domains that segregate proteins in live cells.
Toulmay A, Prinz WA.
J Cell Biol (2013 Jul 8) 202:35-44. Abstract/Full Text

Additional Publications

Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER.
Friedman JR, Kannan M, Toulmay A, Jan CH, Weissman JS, Prinz WA, Nunnari J.
Dev Cell (2018 Jan 22) 44:261-270.e6. Abstract/Full Text
Fat storage-inducing transmembrane (FIT or FITM) proteins are related to lipid phosphatase/phosphotransferase enzymes.
Hayes M, Choudhary V, Ojha N, Shin JJ, Han GS, Carman GM, Loewen CJ, Prinz WA, Levine T.
Microb Cell (2017 Dec 28) 5:88-103. Abstract/Full Text
A cholesterol-sensing mechanism unfolds.
Prinz WA.
J Biol Chem (2017 Dec 8) 292:19974-19975. Abstract/Full Text
Sequences flanking the transmembrane segments facilitate mitochondrial localization and membrane fusion by mitofusin.
Huang X, Zhou X, Hu X, Joshi AS, Guo X, Zhu Y, Chen Q, Prinz WA, Hu J.
Proc Natl Acad Sci U S A (2017 Nov 14) 114:E9863-E9872. Abstract/Full Text
Sterol transporters at membrane contact sites regulate TORC1 and TORC2 signaling.
Murley A, Yamada J, Niles BJ, Toulmay A, Prinz WA, Powers T, Nunnari J.
J Cell Biol (2017 Sep 4) 216:2679-2689. Abstract/Full Text
Organelle biogenesis in the endoplasmic reticulum.
Joshi AS, Zhang H, Prinz WA.
Nat Cell Biol (2017 Aug) 19:876-882. Abstract/Full Text
Phosphatidylserine synthesis at membrane contact sites promotes its transport out of the ER.
Kannan M, Lahiri S, Liu LK, Choudhary V, Prinz WA.
J Lipid Res (2017 Mar) 58:553-562. Abstract/Full Text
Glycerolipid synthesis and lipid trafficking in plant mitochondria.
Michaud M, Prinz WA, Jouhet J.
FEBS J (2017 Feb) 284:376-390. Abstract/Full Text
Endoplasmic reticulum stress affects the transport of phosphatidylethanolamine from mitochondria to the endoplasmic reticulum in S.cerevisiae.
Kannan M, Sivaprakasam C, Prinz WA, Nachiappan V.
Biochim Biophys Acta (2016 Dec) 1861:1959-1967. Abstract/Full Text
Keeping FIT, storing fat: Lipid droplet biogenesis.
Choudhary V, Golden A, Prinz WA.
Worm (2016 Apr-Jun) 5:e1170276. Abstract/Full Text
AtMic60 Is Involved in Plant Mitochondria Lipid Trafficking and Is Part of a Large Complex.
Michaud M, Gros V, Tardif M, Brugière S, Ferro M, Prinz WA, Toulmay A, Mathur J, Wozny M, Falconet D, Maréchal E, Block MA, Jouhet J.
Curr Biol (2016 Mar 7) 26:627-39. Abstract/Full Text
A conserved family of proteins facilitates nascent lipid droplet budding from the ER.
Choudhary V, Ojha N, Golden A, Prinz WA.
J Cell Biol (2015 Oct 26) 211:261-71. Abstract/Full Text
Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts.
Murley A, Sarsam RD, Toulmay A, Yamada J, Prinz WA, Nunnari J.
J Cell Biol (2015 May 25) 209:539-48. Abstract/Full Text
Membrane contact sites, gateways for lipid homeostasis.
Lahiri S, Toulmay A, Prinz WA.
Curr Opin Cell Biol (2015 Apr) 33:82-87. Abstract/Full Text
A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria.
Lahiri S, Chao JT, Tavassoli S, Wong AK, Choudhary V, Young BP, Loewen CJ, Prinz WA.
PLoS Biol (2014 Oct) 12:e1001969. Abstract/Full Text
Editorial overview: Cell organelles.
Banfield DK, Prinz W.
Curr Opin Cell Biol (2014 Aug) 29:v-vi. Abstract/Full Text
Bridging the gap: membrane contact sites in signaling, metabolism, and organelle dynamics.
Prinz WA.
J Cell Biol (2014 Jun 23) 205:759-69. Abstract/Full Text
The lipid trade.
Prinz WA.
Nat Rev Mol Cell Biol (2014 Feb) 15:79. Abstract/Full Text
Plasma membrane--endoplasmic reticulum contact sites regulate phosphatidylcholine synthesis.
Tavassoli S, Chao JT, Young BP, Cox RC, Prinz WA, de Kroon AI, Loewen CJ.
EMBO Rep (2013 May) 14:434-40. Abstract/Full Text
A bridge to understanding lipid droplet growth.
Prinz WA.
Dev Cell (2013 Feb 25) 24:335-6. Abstract/Full Text
ER-shaping proteins facilitate lipid exchange between the ER and mitochondria in S. cerevisiae.
Voss C, Lahiri S, Young BP, Loewen CJ, Prinz WA.
J Cell Sci (2012 Oct 15) 125:4791-9. Abstract/Full Text
Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion.
Liu TY, Bian X, Sun S, Hu X, Klemm RW, Prinz WA, Rapoport TA, Hu J.
Proc Natl Acad Sci U S A (2012 Aug 7) 109:E2146-54. Abstract/Full Text
The budding yeast nuclear envelope adjacent to the nucleolus serves as a membrane sink during mitotic delay.
Witkin KL, Chong Y, Shao S, Webster MT, Lahiri S, Walters AD, Lee B, Koh JL, Prinz WA, Andrews BJ, Cohen-Fix O.
Curr Biol (2012 Jun 19) 22:1128-33. Abstract/Full Text
The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae.
Anwar K, Klemm RW, Condon A, Severin KN, Zhang M, Ghirlando R, Hu J, Rapoport TA, Prinz WA.
J Cell Biol (2012 Apr 16) 197:209-17. Abstract/Full Text
A conserved membrane-binding domain targets proteins to organelle contact sites.
Toulmay A, Prinz WA.
J Cell Sci (2012 Jan 1) 125:49-58. Abstract/Full Text
Weaving the web of ER tubules.
Hu J, Prinz WA, Rapoport TA.
Cell (2011 Dec 9) 147:1226-31. Abstract/Full Text
Lipid transfer and signaling at organelle contact sites: the tip of the iceberg.
Toulmay A, Prinz WA.
Curr Opin Cell Biol (2011 Aug) 23:458-63. Abstract/Full Text
A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking.
Du X, Kumar J, Ferguson C, Schulz TA, Ong YS, Hong W, Prinz WA, Parton RG, Brown AJ, Yang H.
J Cell Biol (2011 Jan 10) 192:121-35. Abstract/Full Text
Lipid trafficking sans vesicles: where, why, how?
Prinz WA.
Cell (2010 Dec 10) 143:870-4. Abstract/Full Text
Mechanisms determining the morphology of the peripheral ER.
Shibata Y, Shemesh T, Prinz WA, Palazzo AF, Kozlov MM, Rapoport TA.
Cell (2010 Nov 24) 143:774-88. Abstract/Full Text
Metabolic response to iron deficiency in Saccharomyces cerevisiae.
Shakoury-Elizeh M, Protchenko O, Berger A, Cox J, Gable K, Dunn TM, Prinz WA, Bard M, Philpott CC.
J Biol Chem (2010 May 7) 285:14823-33. Abstract/Full Text
The diverse functions of oxysterol-binding proteins.
Raychaudhuri S, Prinz WA.
Annu Rev Cell Dev Biol (2010) 26:157-77. Abstract/Full Text
Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues.
Schulz TA, Choi MG, Raychaudhuri S, Mears JA, Ghirlando R, Hinshaw JE, Prinz WA.
J Cell Biol (2009 Dec 14) 187:889-903. Abstract/Full Text
Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response.
Schuck S, Prinz WA, Thorn KS, Voss C, Walter P.
J Cell Biol (2009 Nov 16) 187:525-36. Abstract/Full Text
Membrane-bending proteins.
Prinz WA, Hinshaw JE.
Crit Rev Biochem Mol Biol (2009 Sep-Oct) 44:278-91. Abstract/Full Text
A class of dynamin-like GTPases involved in the generation of the tubular ER network.
Hu J, Shibata Y, Zhu PP, Voss C, Rismanchi N, Prinz WA, Rapoport TA, Blackstone C.
Cell (2009 Aug 7) 138:549-61. Abstract/Full Text
Control of protein and sterol trafficking by antagonistic activities of a type IV P-type ATPase and oxysterol binding protein homologue.
Muthusamy BP, Raychaudhuri S, Natarajan P, Abe F, Liu K, Prinz WA, Graham TR.
Mol Biol Cell (2009 Jun) 20:2920-31. Abstract/Full Text
Calmodulin-driven nuclear entry: trigger for sex determination and terminal differentiation.
Hanover JA, Love DC, Prinz WA.
J Biol Chem (2009 May 8) 284:12593-7. Abstract/Full Text
Nonvesicular phospholipid transfer between peroxisomes and the endoplasmic reticulum.
Raychaudhuri S, Prinz WA.
Proc Natl Acad Sci U S A (2008 Oct 14) 105:15785-90. Abstract/Full Text
Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae.
Federovitch CM, Jones YZ, Tong AH, Boone C, Prinz WA, Hampton RY.
Mol Biol Cell (2008 Oct) 19:4506-20. Abstract/Full Text
The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum.
Shibata Y, Voss C, Rist JM, Hu J, Rapoport TA, Prinz WA, Voeltz GK.
J Biol Chem (2008 Jul 4) 283:18892-904. Abstract/Full Text
Dynamics of cholesterol exchange in the oxysterol binding protein family.
Canagarajah BJ, Hummer G, Prinz WA, Hurley JH.
J Mol Biol (2008 May 2) 378:737-48. Abstract/Full Text
Membrane proteins of the endoplasmic reticulum induce high-curvature tubules.
Hu J, Shibata Y, Voss C, Shemesh T, Li Z, Coughlin M, Kozlov MM, Rapoport TA, Prinz WA.
Science (2008 Feb 29) 319:1247-50. Abstract/Full Text
Sterol transport in yeast and the oxysterol binding protein homologue (OSH) family.
Schulz TA, Prinz WA.
Biochim Biophys Acta (2007 Jun) 1771:769-80. Abstract/Full Text
Sheets, ribbons and tubules - how organelles get their shape.
Voeltz GK, Prinz WA.
Nat Rev Mol Cell Biol (2007 Mar) 8:258-64. Abstract/Full Text