Publications

A selection of recent and significant publications can be viewed below.

Select Publications

Architecture of Lipid Droplets in Endoplasmic Reticulum Is Determined by Phospholipid Intrinsic Curvature.: Choudhary V, Golani G, Joshi AS, Cottier S, Schneiter R, Prinz WA, Kozlov MM.; Curr Biol (2018 Mar 19) 28:915-926.e9. Abstract/Full Text
Lipid droplet and peroxisome biogenesis occur at the same ER subdomains.: Joshi AS, Nebenfuehr B, Choudhary V, Satpute-Krishnan P, Levine TP, Golden A, Prinz WA.; Nat Commun (2018 Jul 27) 9:2940. Abstract/Full Text
An inducible ER-Golgi tether facilitates ceramide transport to alleviate lipotoxicity.: Liu LK, Choudhary V, Toulmay A, Prinz WA.; J Cell Biol (2017 Jan 2) 216:131-147. Abstract/Full Text
A family of membrane-shaping proteins at ER subdomains regulates pre-peroxisomal vesicle biogenesis.: Joshi AS, Huang X, Choudhary V, Levine TP, Hu J, Prinz WA.; J Cell Biol (2016 Nov 21) 215:515-529. Abstract/Full Text
Direct imaging reveals stable, micrometer-scale lipid domains that segregate proteins in live cells.: Toulmay A, Prinz WA.; J Cell Biol (2013 Jul 8) 202:35-44. Abstract/Full Text

Additional Publications

Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER.: Friedman JR, Kannan M, Toulmay A, Jan CH, Weissman JS, Prinz WA, Nunnari J.; Dev Cell (2018 Jan 22) 44:261-270.e6. Abstract/Full Text
Fat storage-inducing transmembrane (FIT or FITM) proteins are related to lipid phosphatase/phosphotransferase enzymes.: Hayes M, Choudhary V, Ojha N, Shin JJ, Han GS, Carman GM, Loewen CJ, Prinz WA, Levine T.; Microb Cell (2017 Dec 28) 5:88-103. Abstract/Full Text
A cholesterol-sensing mechanism unfolds.: Prinz WA.; J Biol Chem (2017 Dec 8) 292:19974-19975. Abstract/Full Text
Sequences flanking the transmembrane segments facilitate mitochondrial localization and membrane fusion by mitofusin.: Huang X, Zhou X, Hu X, Joshi AS, Guo X, Zhu Y, Chen Q, Prinz WA, Hu J.; Proc Natl Acad Sci U S A (2017 Nov 14) 114:E9863-E9872. Abstract/Full Text
Sterol transporters at membrane contact sites regulate TORC1 and TORC2 signaling.: Murley A, Yamada J, Niles BJ, Toulmay A, Prinz WA, Powers T, Nunnari J.; J Cell Biol (2017 Sep 4) 216:2679-2689. Abstract/Full Text
Organelle biogenesis in the endoplasmic reticulum.: Joshi AS, Zhang H, Prinz WA.; Nat Cell Biol (2017 Aug) 19:876-882. Abstract/Full Text
Phosphatidylserine synthesis at membrane contact sites promotes its transport out of the ER.: Kannan M, Lahiri S, Liu LK, Choudhary V, Prinz WA.; J Lipid Res (2017 Mar) 58:553-562. Abstract/Full Text
Glycerolipid synthesis and lipid trafficking in plant mitochondria.: Michaud M, Prinz WA, Jouhet J.; FEBS J (2017 Feb) 284:376-390. Abstract/Full Text
Endoplasmic reticulum stress affects the transport of phosphatidylethanolamine from mitochondria to the endoplasmic reticulum in S.cerevisiae.: Kannan M, Sivaprakasam C, Prinz WA, Nachiappan V.; Biochim Biophys Acta (2016 Dec) 1861:1959-1967. Abstract/Full Text
Keeping FIT, storing fat: Lipid droplet biogenesis.: Choudhary V, Golden A, Prinz WA.; Worm (2016 Apr-Jun) 5:e1170276. Abstract/Full Text
AtMic60 Is Involved in Plant Mitochondria Lipid Trafficking and Is Part of a Large Complex.: Michaud M, Gros V, Tardif M, Brugière S, Ferro M, Prinz WA, Toulmay A, Mathur J, Wozny M, Falconet D, Maréchal E, Block MA, Jouhet J.; Curr Biol (2016 Mar 7) 26:627-39. Abstract/Full Text
A conserved family of proteins facilitates nascent lipid droplet budding from the ER.: Choudhary V, Ojha N, Golden A, Prinz WA.; J Cell Biol (2015 Oct 26) 211:261-71. Abstract/Full Text
Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts.: Murley A, Sarsam RD, Toulmay A, Yamada J, Prinz WA, Nunnari J.; J Cell Biol (2015 May 25) 209:539-48. Abstract/Full Text
Membrane contact sites, gateways for lipid homeostasis.: Lahiri S, Toulmay A, Prinz WA.; Curr Opin Cell Biol (2015 Apr) 33:82-87. Abstract/Full Text
A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria.: Lahiri S, Chao JT, Tavassoli S, Wong AK, Choudhary V, Young BP, Loewen CJ, Prinz WA.; PLoS Biol (2014 Oct) 12:e1001969. Abstract/Full Text
Editorial overview: Cell organelles.: Banfield DK, Prinz W.; Curr Opin Cell Biol (2014 Aug) 29:v-vi. Abstract/Full Text
Bridging the gap: membrane contact sites in signaling, metabolism, and organelle dynamics.: Prinz WA.; J Cell Biol (2014 Jun 23) 205:759-69. Abstract/Full Text
The lipid trade.: Prinz WA.; Nat Rev Mol Cell Biol (2014 Feb) 15:79. Abstract/Full Text
Plasma membrane--endoplasmic reticulum contact sites regulate phosphatidylcholine synthesis.: Tavassoli S, Chao JT, Young BP, Cox RC, Prinz WA, de Kroon AI, Loewen CJ.; EMBO Rep (2013 May) 14:434-40. Abstract/Full Text
A bridge to understanding lipid droplet growth.: Prinz WA.; Dev Cell (2013 Feb 25) 24:335-6. Abstract/Full Text
ER-shaping proteins facilitate lipid exchange between the ER and mitochondria in S. cerevisiae.: Voss C, Lahiri S, Young BP, Loewen CJ, Prinz WA.; J Cell Sci (2012 Oct 15) 125:4791-9. Abstract/Full Text
Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion.: Liu TY, Bian X, Sun S, Hu X, Klemm RW, Prinz WA, Rapoport TA, Hu J.; Proc Natl Acad Sci U S A (2012 Aug 7) 109:E2146-54. Abstract/Full Text
The budding yeast nuclear envelope adjacent to the nucleolus serves as a membrane sink during mitotic delay.: Witkin KL, Chong Y, Shao S, Webster MT, Lahiri S, Walters AD, Lee B, Koh JL, Prinz WA, Andrews BJ, Cohen-Fix O.; Curr Biol (2012 Jun 19) 22:1128-33. Abstract/Full Text
The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae.: Anwar K, Klemm RW, Condon A, Severin KN, Zhang M, Ghirlando R, Hu J, Rapoport TA, Prinz WA.; J Cell Biol (2012 Apr 16) 197:209-17. Abstract/Full Text
A conserved membrane-binding domain targets proteins to organelle contact sites.: Toulmay A, Prinz WA.; J Cell Sci (2012 Jan 1) 125:49-58. Abstract/Full Text
Weaving the web of ER tubules.: Hu J, Prinz WA, Rapoport TA.; Cell (2011 Dec 9) 147:1226-31. Abstract/Full Text
Lipid transfer and signaling at organelle contact sites: the tip of the iceberg.: Toulmay A, Prinz WA.; Curr Opin Cell Biol (2011 Aug) 23:458-63. Abstract/Full Text
A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking.: Du X, Kumar J, Ferguson C, Schulz TA, Ong YS, Hong W, Prinz WA, Parton RG, Brown AJ, Yang H.; J Cell Biol (2011 Jan 10) 192:121-35. Abstract/Full Text
Lipid trafficking sans vesicles: where, why, how?: Prinz WA.; Cell (2010 Dec 10) 143:870-4. Abstract/Full Text
Mechanisms determining the morphology of the peripheral ER.: Shibata Y, Shemesh T, Prinz WA, Palazzo AF, Kozlov MM, Rapoport TA.; Cell (2010 Nov 24) 143:774-88. Abstract/Full Text
Metabolic response to iron deficiency in Saccharomyces cerevisiae.: Shakoury-Elizeh M, Protchenko O, Berger A, Cox J, Gable K, Dunn TM, Prinz WA, Bard M, Philpott CC.; J Biol Chem (2010 May 7) 285:14823-33. Abstract/Full Text
The diverse functions of oxysterol-binding proteins.: Raychaudhuri S, Prinz WA.; Annu Rev Cell Dev Biol (2010) 26:157-77. Abstract/Full Text
Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues.: Schulz TA, Choi MG, Raychaudhuri S, Mears JA, Ghirlando R, Hinshaw JE, Prinz WA.; J Cell Biol (2009 Dec 14) 187:889-903. Abstract/Full Text
Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response.: Schuck S, Prinz WA, Thorn KS, Voss C, Walter P.; J Cell Biol (2009 Nov 16) 187:525-36. Abstract/Full Text
Membrane-bending proteins.: Prinz WA, Hinshaw JE.; Crit Rev Biochem Mol Biol (2009 Sep-Oct) 44:278-91. Abstract/Full Text
A class of dynamin-like GTPases involved in the generation of the tubular ER network.: Hu J, Shibata Y, Zhu PP, Voss C, Rismanchi N, Prinz WA, Rapoport TA, Blackstone C.; Cell (2009 Aug 7) 138:549-61. Abstract/Full Text
Control of protein and sterol trafficking by antagonistic activities of a type IV P-type ATPase and oxysterol binding protein homologue.: Muthusamy BP, Raychaudhuri S, Natarajan P, Abe F, Liu K, Prinz WA, Graham TR.; Mol Biol Cell (2009 Jun) 20:2920-31. Abstract/Full Text
Calmodulin-driven nuclear entry: trigger for sex determination and terminal differentiation.: Hanover JA, Love DC, Prinz WA.; J Biol Chem (2009 May 8) 284:12593-7. Abstract/Full Text
Nonvesicular phospholipid transfer between peroxisomes and the endoplasmic reticulum.: Raychaudhuri S, Prinz WA.; Proc Natl Acad Sci U S A (2008 Oct 14) 105:15785-90. Abstract/Full Text
Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae.: Federovitch CM, Jones YZ, Tong AH, Boone C, Prinz WA, Hampton RY.; Mol Biol Cell (2008 Oct) 19:4506-20. Abstract/Full Text
The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum.: Shibata Y, Voss C, Rist JM, Hu J, Rapoport TA, Prinz WA, Voeltz GK.; J Biol Chem (2008 Jul 4) 283:18892-904. Abstract/Full Text
Dynamics of cholesterol exchange in the oxysterol binding protein family.: Canagarajah BJ, Hummer G, Prinz WA, Hurley JH.; J Mol Biol (2008 May 2) 378:737-48. Abstract/Full Text
Membrane proteins of the endoplasmic reticulum induce high-curvature tubules.: Hu J, Shibata Y, Voss C, Shemesh T, Li Z, Coughlin M, Kozlov MM, Rapoport TA, Prinz WA.; Science (2008 Feb 29) 319:1247-50. Abstract/Full Text
Sterol transport in yeast and the oxysterol binding protein homologue (OSH) family.: Schulz TA, Prinz WA.; Biochim Biophys Acta (2007 Jun) 1771:769-80. Abstract/Full Text
Sheets, ribbons and tubules - how organelles get their shape.: Voeltz GK, Prinz WA.; Nat Rev Mol Cell Biol (2007 Mar) 8:258-64. Abstract/Full Text