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Krystyna Rys-Sikora, Ph.D.

Responsibilities & Activities

As director of the Acute Kidney Injury and Chronic Kidney Disease Basic Science programs, my responsibilities include overseeing a portfolio of research on these and related disorders. These research programs focus on the causes, pathogenetic mechanisms, and pathophysiology of acute kidney injury and chronic kidney disease in humans and animal models. Other topics in my portfolio include podocyte biology, fibrosis,renal hemodynamics; renal conditions associated with hypertension, kidney cellular signaling and crosstalk, lipid-mediated signaling, multi-omics studies, systems biology, and imaging techniques. I also am the Kidney T32 program director.

Research Programs

Acute Kidney Injury
The mechanisms and pathophysiology underlying AKI and its progression.

Chronic Kidney Disease
The mechanisms and pathophysiology underlying renal disease and its progression.

Diabetic Kidney Disease
The mechanisms and pathophysiology underlying diabetic nephropathy and its progression.

End-Stage Renal Disease
The mechanisms and pathophysiology of kidney failure and the progression of chronic kidney disease to kidney failure.

Kidney Basic Research
The mechanisms and pathophysiology underlying renal disease and its progression.

Kidney Bioengineering, Biotechnology, & Imaging
The development of new technologies for the diagnosis, monitoring, or treatment of renal disease.

Kidney Developmental Biology & Aging
Research on the developing and aging kidney.

Kidney Inflammation & Inflammatory Diseases
Normal and pathologic renal processes involving immune- or inflammatory-mediated mechanisms.

Committees & Working Groups

  • NIDDK Fibrosis Initiative Working Group, Member
  • KUH Kidney Precision Medicine Project - Tissue Interrogation Sites, Member
  • NIDDK Regenerative Medicine Focus Group - Working Group, Member
  • NIDDK Training Directors Work Group, Member