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  4. Sheryl Sato, Ph.D.

Sheryl Sato, Ph.D.

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Basic mechanisms underlying the organogenesis and regeneration of pancreatic islets during health and disease

Responsibilities & Activities

My responsibilities include managing basic science research programs in developmental biology, stem cell biology and the regeneration of endocrine tissues and organs. I direct a program in islet biology that supports mechanistic studies to understand integrated islet function, pancreatic beta cell renewal, and the pathophysiology of type 1 and type 2 diabetes.

In addition, I help coordinate research in the Human Islet Research Network (HIRN), a basic science research effort which is developing innovative strategies for the treatment, prevention and monitoring of type 1 diabetes. Within HIRN, I serve as the project scientist for the Consortium on Human Islet Biomimetics (CHIB).  I am the project scientist for the Microphysiological Systems for Modeling Diabetes (MPS-MOD), a tissue chip consortium that is developing human disease models of diabetes and obesity. In addition, I serve as the program officer for the Integrated Islet Distribution Program.

In addition to my duties in the Division of Diabetes, Endocrinology, and Metabolic Diseases, I also participate in NIDDK working groups that focus on Type 1 diabetes and Regenerative Medicine.  I serve on the Regenerative Medicine Innovation Project, a trans-NIH committee that is implementing the 21st Century Cures Act in Regenerative Medicine.

Research Programs

Bioengineering, Biotechnology, and Imaging as applied to Diabetes, Metabolic, and Endocrine Diseases
Cutting-edge technologies and integrated approaches that treat and elucidate the underlying mechanisms of endocrine and metabolic diseases, including diabetes.

Endocrine Pancreas
Biology, development, and function of the endocrine pancreas and clinical studies on islet transplantation for type 1 diabetes treatment.

Genetic Metabolic Disease
Basic and clinical studies on the pathophysiology and treatment of inborn errors of metabolism and rare genetic metabolic diseases.

Committees & Working Groups

  • NIDDK Type 1 Diabetes Working Group, Member