Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.
The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit
Updates regarding government operating status and resumption of normal operations can be found at

U.S. Department of Health and Human Services
Arthur Castle

 Contact Info

Tel: 301-594-7719

 Select Experience

  • Bioinformatics Scientist/ Manager/Project ManagerGene Logic2000-2004
  • PRAT FellowNIDDK/NIGMS, NIH1999-2000
  • Postdoctoral TrainingNIDDK, NIH1997-1998
  • Ph.D.University of Texas1997

Arthur L. Castle, Ph.D.

Program Director, Division of Diabetes, Endocrinology, and Metabolic Diseases

Current Responsibilities and Activities

I direct programs that study metabolomics and informatics.  As such, I manage a research portfolio that applies technology to measure the large-scale integrated metabolism of cells, tissues, and organ systems.  These studies measure and identify many metabolites within multiple pathways and aim to discover new relationships between metabolite profile changes and the pathology of specific metabolic diseases or syndromes.  I am a co-coordinator of the Common Fund Metabolomics Initiative.  The NIH Common Fund addresses key roadblocks in biomedical research that impede basic scientific discovery and its translation into improved human health.

As director of the training program, I manage a research portfolio of fellowships and institutional training grants in diabetes, endocrinology, and metabolism.  These fellowships and training appointments provide stipend support for predoctoral and postdoctoral students and fellows doing research in NIDDK mission-related fields.

As the informatics director, I manage a research portfolio of bioinformatics and modeling grants and serve on committees related to bioinformatics.

​Research Programs

Bioengineering, Biotechnology, and Imaging as applied to Diabetes, Metabolic, and Endocrine Diseases
This program supports research that is aimed at applying sophisticated, cutting-edge technologies to advance the understanding of the mechanisms that underlie diabetes and other endocrine and metabolic diseases