U.S. Department of Health and Human Services
Carol Renfrew Haft

 Contact Info

Tel: 301-594-7689
Email: haftc@mail.nih.gov

 Select Experience

  • Program DirectorCell Biology and Adipocyte Biology, NIDDK, NIH2000-2004
  • Staff ScientistDiabetes Branch, NIDDK, NIH1999-2000
  • Senior Staff FellowNIDDK, NIH1996-1999
  • Research FellowNIDDK, NIH1991-1996
  • Ph.D.The Johns Hopkins University School of Medicine1991

Carol Renfrew Haft, Ph.D.

Program Director, Division of Diabetes, Endocrinology, and Metabolic Diseases

Current Responsibilities & Activities

As a senior advisor for cell biology, I am responsible for managing a research portfolio focused on fundamental cell processes such as endoplasmic reticulum stress, the unfolded protein response (UPR), as well as protein secretion, mis-folding and mis-processing in cells of metabolic tissues.  I also serve as director for the Adipocyte Biology program and manage a portfolio of grants that focus on the life cycle of adipocytes and on fat tissue biology.  The program includes studies of the development, maintenance, plasticity and turnover of different types of adipocytes (white, brown, beige and marrow fat cells); lipid droplet biogenesis and signaling; regulation of fatty acid turnover and storage; adipokine generation and secretion;  the role of immune cells, endothelial cells, extracellular matrix components and cells of the stroma in determining the metabolic properties of different fat depot and in each depot’s response to excess nutrients and signals from other tissues; and the regulation of thermogenesis.  Studies in model organisms, rodents, human cells, human subjects as well as bioengineered materials are welcomed.

I coordinate the Division’s NIDDK Advisory Council activities and work with other units in the NIDDK to coordinate the Division’s expenditure of funds.  I participate in several NIDDK working groups, including those focused on obesity, translation, council operations, and training and career development.

​Research Programs

Endocrinology and Hormone Signaling
This program supports basic and clinical research on neuroendocrinology and general endocrinology, the HPA axis, bone metabolism, mechanisms of nuclear receptor signaling, and signaling pathways involved in nutrient sensing at target tissues

Genetic Metabolic Disease
This program supports basic and clinical research that addresses the pathophysiology and treatment of inborn errors of metabolism and rare genetic metabolic diseases, including lipodystrophy, maturity onset diabetes of the young (MODY), Primary Hyperoxaluria, systemic amyloidosis and porphyria.

Metabolic Pathways
This program supports research on the pathways that are involved in intermediary metabolism, from a whole-body, tissue, cellular, or the molecular perspective, as they impact metabolic diseases

Metabolism, Energy Balance, and Obesity
This program supports research on metabolism, energy balance, and obesity