U.S. Department of Health and Human Services
Luke Stoeckel

 Contact Info

Tel: 301-741-9223
Email: luke.stoeckel@nih.gov

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Luke E Stoeckel, Ph.D.

Program Director, Division of Diabetes, Endocrinology, and Metabolic Diseases

Current Responsibilities & Activities

As Director of the Cognitive and Clinical Neuroscience of Obesity and Diabetes Program, I manage a portfolio of basic and applied cognitive, behavioral, and clinical neuroscience research focused on the non-homeostatic brain-behavior mechanisms related to the pathophysiology, diagnosis, prevention, and treatment of obesity and diabetes across the lifespan and in special populations.. Special populations include individuals with neurological disease and psychiatric illness, but only if the work directly relates to obesity, diabetes, or other metabolic disease. The goal of this program is to translate basic neuroscience discoveries into novel, brain-based interventions for obesity and diabetes. My portfolio also includes  basic behavioral science in humans to understand mechanisms of behavior change and identify psychological or behavioral phenotypes that explain individual differences in outcomes or response to intervention.


Specific areas of support and interest include the interaction between homeostatic and non-homeostatic neural systems and peripheral endocrine and metabolic signals; mapping abnormal patterns of brain connectivity between homeostatic and non-homeostatic neural systems; computational and statistical modeling of high-dimensional genetic, neuroimaging, and cognitive data and the contribution to complex behaviors such as food intake and physical activity; cognitive dysfunction in obesity and diabetes; the interaction between brain function and other non-ingestive biological (e.g., sleep) and environmental (e.g., stress) factors that contribute to obesity and diabetes; and the effects of treatment (e.g., weight loss surgery, cognitive and psychological therapy) on brain function and behavior in obesity and diabetes.


Research projects employ invasive and non-invasive neuroimaging tools (e.g., optogenetics, TMS, TDCS, EEG, fNIRS, PET, MRI/fMRI) and advanced methods for recording, modeling, and altering brain structure and function and associated neuropsychological functions in humans and other animals.


​Research Programs

Bioengineering, Biotechnology, and Imaging as applied to Diabetes, Metabolic, and Endocrine Diseases
This program supports research that is aimed at applying sophisticated, cutting-edge technologies to advance the understanding of the mechanisms that underlie diabetes and other endocrine and metabolic diseases

Clinical Research in Type 2 Diabetes
This program supports studies in humans aimed at the prevention, treatment, and diagnosis of type 2 diabetes across the lifespan, as well as further characterizing and understanding the mechanistic aspects of the etiology of type 2 diabetes

Diabetes: Treatment, Prevention, and Complications
This program supports both basic and clinical studies aimed at addressing the prevention, treatment, and pathophysiology of type 1 and type 2 diabetes

Metabolism, Energy Balance, and Obesity
This program supports research on metabolism, energy balance, and obesity

Neurobiology of Obesity
The Neurobiology of Obesity program encompasses research on the regulation of body composition by circulating factors