U.S. Department of Health and Human Services
Aaron Cypess

 Contact Info

Tel: 301-435-9267
Email: aaron.cypess@nih.gov

 Select Experience

  • Assistant Professor of MedicineHarvard Medical School2010-2014
  • Assistant Investigator and Staff PhysicianJoslin Diabetes Center2010-2014
  • Beth Israel Deaconess Medical CenterStaff Physician2006-2014
  • M.M.Sc.Harvard Medical School2008
  • M.D.Cornell Medical College2000
  • Ph.D.Rockefeller University1999
  • A.B.Princeton University1992

 Related Links


Aaron M. Cypess, M.D., Ph.D., M.M.Sc.

Acting Section Chief, Translational Physiology SectionDiabetes, Endocrinology, and Obesity Branch
  • Cell Biology/Cell Signaling
  • Clinical Research
  • Molecular Biology/Biochemistry
  • Molecular Pharmacology/Toxicology


A selection of recent and significant publications can be viewed below.

Cypess AM, Weiner LS, Roberts-Toler C, Franquet Elía E, Kessler SH, Kahn PA, English J, Chatman K, Trauger SA, Doria A, Kolodny GM. Activation of human brown adipose tissue by a β3-adrenergic receptor agonist. Cell Metab. 2015 Jan 6; 21 (2015 Jan 6; 21; 1):33-8. [Full Text/Abstract]
Cypess AM, Haft CR, Laughlin MR, Hu HH. Brown fat in humans: consensus points and experimental guidelines. Cell Metab. 2014 Sep 2; 20 (20; 2014 Sep 2; 3):408-15. [Full Text/Abstract]
Srinivasa S, Wong K, Fitch KV, Wei J, Petrow E, Cypess AM, Torriani M, Grinspoon SK. Effects of lifestyle modification and metformin on irisin and FGF21 among HIV-infected subjects with the metabolic syndrome. Clin Endocrinol (Oxf). 2014 Aug 16; 82 (2014 Aug 16; 82; 5):678-85. [Full Text/Abstract]
Mori MA, Thomou T, Boucher J, Lee KY, Lallukka S, Kim JK, Torriani M, Yki-Järvinen H, Grinspoon SK, Cypess AM, Kahn CR. Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. J Clin Invest. 2014 Aug 1; 124 (124; 8; 2014 Aug 1):3339-51. [Full Text/Abstract]
Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Sci Transl Med. 2014 Jul 30; 6 (6; 247; 2014 Jul 30):247ra103. [Full Text/Abstract]
Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED. IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell. 2014 Jul 3; 158 (158; 1; 2014 Jul 3):69-83. [Full Text/Abstract]
Zhang Z, Cypess AM, Miao Q, Ye H, Liew CW, Zhang Q, Xue R, Zhang S, Zuo C, Xu Z, Tang Q, Hu R, Guan Y, Li Y. The prevalence and predictors of active brown adipose tissue in Chinese adults. Eur J Endocrinol. 2014 Mar; 170 (2014 Mar; 170; 3):359-66. [Full Text/Abstract]
Cypess AM, Doyle AN, Sass CA, Huang TL, Mowschenson PM, Rosen HN, Tseng YH, Palmer EL 3rd, Kolodny GM. Quantification of human and rodent brown adipose tissue function using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT. J Nucl Med. 2013 Nov; 54 (2013 Nov; 54; 11):1896-901. [Full Text/Abstract]
Chen YC, Cypess AM, Chen YC, Palmer M, Kolodny G, Kahn CR, Kwong KK. Measurement of human brown adipose tissue volume and activity using anatomic MR imaging and functional MR imaging. J Nucl Med. 2013 Sep; 54 (2013 Sep; 9; 54):1584-7. [Full Text/Abstract]
Cypess AM, White AP, Vernochet C, Schulz TJ, Xue R, Sass CA, Huang TL, Roberts-Toler C, Weiner LS, Sze C, Chacko AT, Deschamps LN, Herder LM, Truchan N, Glasgow AL, Holman AR, Gavrila A, Hasselgren PO, Mori MA, Molla M, Tseng YH. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med. 2013 May; 19 (2013 May; 19; 5):635-9. [Full Text/Abstract]
Schulz TJ, Huang P, Huang TL, Xue R, McDougall LE, Townsend KL, Cypess AM, Mishina Y, Gussoni E, Tseng YH. Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature. 2013 Mar 21; 495 (495; 7441; 2013 Mar 21):379-83. [Full Text/Abstract]
Torriani M, Zanni MV, Fitch K, Stavrou E, Bredella MA, Lim R, Cypess AM, Grinspoon S. Increased FDG uptake in association with reduced extremity fat in HIV patients. Antivir Ther. 2013; 18 (2; 18; 2013):243-8. [Full Text/Abstract]
Chen YI, Cypess AM, Sass CA, Brownell AL, Jokivarsi KT, Kahn CR, Kwong KK. Anatomical and functional assessment of brown adipose tissue by magnetic resonance imaging. Obesity (Silver Spring). 2012 Jul; 20 (20; 7; 2012 Jul):1519-26. [Full Text/Abstract]
Cypess AM, Chen YC, Sze C, Wang K, English J, Chan O, Holman AR, Tal I, Palmer MR, Kolodny GM, Kahn CR. Cold but not sympathomimetics activates human brown adipose tissue in vivo. Proc Natl Acad Sci U S A. 2012 Jun 19; 109 (25; 109; 2012 Jun 19):10001-5. [Full Text/Abstract]
Torriani M, Fitch K, Stavrou E, Bredella MA, Lim R, Sass CA, Cypess AM, Grinspoon S. Deiodinase 2 expression is increased in dorsocervical fat of patients with HIV-associated lipohypertrophy syndrome. J Clin Endocrinol Metab. 2012 Apr; 97 (97; 4; 2012 Apr):E602-7. [Full Text/Abstract]
Drubach LA, Palmer EL 3rd, Connolly LP, Baker A, Zurakowski D, Cypess AM. Pediatric brown adipose tissue: detection, epidemiology, and differences from adults. J Pediatr. 2011 Dec; 159 (6; 2011 Dec; 159):939-44. [Full Text/Abstract]
Cypess AM, Zhang H, Schulz TJ, Huang TL, Espinoza DO, Kristiansen K, Unterman TG, Tseng YH. Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways. Endocrinology. 2011 Oct; 152 (152; 2011 Oct; 10):3680-9. [Full Text/Abstract]
Cypess AM. A new connection between muscle and brown fat. J Pediatr. 2011 May; 158 (158; 5; 2011 May):696-8. [Full Text/Abstract]
Cypess AM, Kahn CR. The role and importance of brown adipose tissue in energy homeostasis. Curr Opin Pediatr. 2010 Aug; 22 (4; 2010 Aug; 22):478-84. [Full Text/Abstract]
Tseng YH, Cypess AM, Kahn CR. Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov. 2010 Jun; 9 (2010 Jun; 6; 9):465-82. [Full Text/Abstract]
Cypess AM, Kahn CR. Brown fat as a therapy for obesity and diabetes. Curr Opin Endocrinol Diabetes Obes. 2010 Apr; 17 (2; 17; 2010 Apr):143-9. [Full Text/Abstract]
Bouche C, Lopez X, Fleischman A, Cypess AM, O'Shea S, Stefanovski D, Bergman RN, Rogatsky E, Stein DT, Kahn CR, Kulkarni RN, Goldfine AB. Insulin enhances glucose-stimulated insulin secretion in healthy humans. Proc Natl Acad Sci U S A. 2010 Mar 9; 107 (107; 2010 Mar 9; 10):4770-5. [Full Text/Abstract]
Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009 Apr 9; 360 (2009 Apr 9; 15; 360):1509-17. [Full Text/Abstract]
Tseng YH, Butte AJ, Kokkotou E, Yechoor VK, Taniguchi CM, Kriauciunas KM, Cypess AM, Niinobe M, Yoshikawa K, Patti ME, Kahn CR. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol. 2005 Jun; 7 (6; 7; 2005 Jun):601-11. [Full Text/Abstract]
Carucci JA, Ignatius R, Wei Y, Cypess AM, Schaer DA, Pope M, Steinman RM, Mojsov S. Calcitonin gene-related peptide decreases expression of HLA-DR and CD86 by human dendritic cells and dampens dendritic cell-driven T cell-proliferative responses via the type I calcitonin gene-related peptide receptor. J Immunol. 2000 Apr 1; 164 (164; 2000 Apr 1; 7):3494-9. [Full Text/Abstract]
Cypess AM, Unson CG, Wu CR, Sakmar TP. Two cytoplasmic loops of the glucagon receptor are required to elevate cAMP or intracellular calcium. J Biol Chem. 1999 Jul 2; 274 (27; 1999 Jul 2; 274):19455-64. [Full Text/Abstract]
Unson CG, Cypess AM, Kim HN, Goldsmith PK, Carruthers CJ, Merrifield RB, Sakmar TP. Characterization of deletion and truncation mutants of the rat glucagon receptor. Seven transmembrane segments are necessary for receptor transport to the plasma membrane and glucagon binding. J Biol Chem. 1995 Nov 17; 270 (46; 270; 1995 Nov 17):27720-7. [Full Text/Abstract]
Buxbaum JD, Ruefli AA, Parker CA, Cypess AM, Greengard P. Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. Proc Natl Acad Sci U S A. 1994 May 10; 91 (1994 May 10; 91; 10):4489-93. [Full Text/Abstract]
Lloyd DK, Cypess AM, Wainer IW. Determination of cytosine-beta-D-arabinoside in plasma using capillary electrophoresis. J Chromatogr. 1991 Jul 17; 568 (1991 Jul 17; 568; 1):117-24. [Full Text/Abstract]
Maneval DC, Magill HL, Cypess AM, Rodman JH. Measurement of skin-to-kidney distance in children: implications for quantitative renography. J Nucl Med. 1990 Mar; 31 (1990 Mar; 3; 31):287-91. [Full Text/Abstract]