U.S. Department of Health and Human Services
Alan Schechter

 Contact Info

Tel: 301-496-5408
Email: aschecht@helix.nih.gov

 Select Experience

  • Special Research FellowNIAMS, NIH1967-1969
  • Research AssociateNIAMS, NIH1965-1967
  • ResidentAlbert Einstein Medical College1963-1965
  • M.D.Columbia University1963
  • B.A.Cornell University1959

 Related Links

  • Molecular Biology/Biochemistry
  • Molecular Pharmacology/Toxicology
Research Summary/In Plain Language

Research Summary

Research Goal

Studying the interaction of blood, especially red cells and hemoglobin, with the recently discovered signaling molecule nitric oxide (NO) should provide new information about normal and abnormal physiology and potential pharmacology.

Current Research

Our research program is currently focused on the interaction of NO and hemoglobin, with the goal of understanding how NO may be transported by blood and thus act at distal sites, opening up its use as a pharmacological agent.  This work has the potential for developing therapies for a variety of ischemic diseases, as well as sickle cell anemia and related hemoglobinopathies in which blood flow is impaired.  Other research projects currently underway involve studies of the pathophysiological role of cell-free hemoglobin, cell signaling in the NO pathway, and the effects of nitrite/NO on platelet function.​

Applying our Research

This research may give us clues regarding how to develop new therapies for several common diseases, as well as improve our understanding and treatment of the genetic anemias.

Need for Further Study

The control of blood flow in human beings, both normally and in disease states, requires further study.