U.S. Department of Health and Human Services
Alison Hickman

 Contact Info

Tel: 301-402-4377
Email: alisonh@helix.nih.gov

 Select Experience

  • Ph.D.Massachusetts Institute of Technology1990
  • B.Sc.McGill University1983

 Related Links


Alison B. Hickman, Ph.D.

Staff Scientist, Structural Biochemistry SectionLaboratory of Molecular Biology
  • Molecular Biology/Biochemistry
  • Structural Biology


A selection of recent and significant publications can be viewed below.

Hickman AB, Ewis HE, Li X, Knapp JA, Laver T, Doss AL, Tolun G, Steven AC, Grishaev A, Bax A, Atkinson PW, Craig NL, Dyda F. Structural basis of hAT transposon end recognition by Hermes, an octameric DNA transposase from Musca domestica. Cell. 2014 Jul 17; 158 (2014 Jul 17; 2; 158):353-367. [Full Text/Abstract]
Dyda F, Chandler M, Hickman AB. The emerging diversity of transpososome architectures. Q Rev Biophys. 2012 Nov; 45 (4; 2012 Nov; 45):493-521. [Full Text/Abstract]
Maggin JE, James JA, Chappie JS, Dyda F, Hickman AB. The amino acid linker between the endonuclease and helicase domains of adeno-associated virus type 5 Rep plays a critical role in DNA-dependent oligomerization. J Virol. 2012 Mar; 86 (86; 6; 2012 Mar):3337-46. [Full Text/Abstract]
Hickman AB, James JA, Barabas O, Pasternak C, Ton-Hoang B, Chandler M, Sommer S, Dyda F. DNA recognition and the precleavage state during single-stranded DNA transposition in D. radiodurans. EMBO J. 2010 Nov 17; 29 (2010 Nov 17; 29; 22):3840-52. [Full Text/Abstract]
Hickman AB, Chandler M, Dyda F. Integrating prokaryotes and eukaryotes: DNA transposases in light of structure. Crit Rev Biochem Mol Biol. 2010 Feb; 45 (2010 Feb; 45; 1):50-69. [Full Text/Abstract]
Hickman AB, Perez ZN, Zhou L, Musingarimi P, Ghirlando R, Hinshaw JE, Craig NL, Dyda F. Molecular architecture of a eukaryotic DNA transposase. Nat Struct Mol Biol. 2005 Aug; 12 (8; 12; 2005 Aug):715-21. [Full Text/Abstract]
Zhou L, Mitra R, Atkinson PW, Hickman AB, Dyda F, Craig NL. Transposition of hAT elements links transposable elements and V(D)J recombination. Nature. 2004 Dec 23; 432 (432; 7020; 2004 Dec 23):995-1001. [Full Text/Abstract]
Hickman AB, Ronning DR, Perez ZN, Kotin RM, Dyda F. The nuclease domain of adeno-associated virus rep coordinates replication initiation using two distinct DNA recognition interfaces. Mol Cell. 2004 Feb 13; 13 (2004 Feb 13; 13; 3):403-14. [Full Text/Abstract]