U.S. Department of Health and Human Services
Alison Hickman
 

 Contact Info

 
Tel: 301-402-4377
Email: alisonh@helix.nih.gov
 

 Select Experience

 
  • Ph.D.Massachusetts Institute of Technology1990
  • B.Sc.McGill University1983
 

 Related Links

 

Alison B. Hickman, Ph.D.

Staff Scientist, Structural Biochemistry SectionLaboratory of Molecular Biology
Specialties
  • Molecular Biology/Biochemistry
  • Structural Biology

​Research Images

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TitleDescriptionImage
The domain organization of the Hermes transposase and the 3D structure of the protein aloneThe Hermes transposase consists of 612 amino acids. On the monomer level, it is a multidomain protein (domains are represented as colored boxes in the schematic on top) organized around a central catalytic core (orange) that is structurally related to E. coli RNase H.The domain organization of the Hermes transposase and the 3D structure of the protein aloneEnlarge
Introduction to the Hermes transposon #1This image depicts some of the reasons why we study Hermes transposition.Introduction to the Hermes transposon #1Enlarge
Introduction to the Hermes transposon #2This image depicts a schematic representation of the cut-and-paste reaction catalyzed by the Hermes transposase. For simplicity, the reactions are shown for only one end (the so-called Left End) of the transposon, so you must imagine the identical reactions are carried out on the Right End (not shown). For comparison, the reaction pathway for a simple bacterial transposase (carried by the Tn5 transposon) is also shown.Introduction to the Hermes transposon #2Enlarge