U.S. Department of Health and Human Services
Andy Golden

 Contact Info

Tel: 301-594-4367
Email: andyg@nih.gov

 Select Experience

  • Senior InvestigatorNIDDKNIH 2006-present
  • InvestigatorNIDDK, NIH2000-2006
  • Program FellowNCI-Frederick1994-1999
  • Post-doctoral FellowCalifornia Institute of Technology1990-1994
  • Ph.D.State University of New York at Stony Brook1990
  • B.S.Muhlenberg College1982

 Related Links

  • Cell Biology/Cell Signaling
  • Developmental Biology
  • Genetics/Genomics
  • Modeling disease in C. elegans


A selection of recent and significant publications can be viewed below.

Boateng R, Nguyen KCQ, Hall DH, Golden A, Allen AK. Novel functions for the RNA-binding protein ETR-1 in Caenorhabditis elegans reproduction and engulfment of germline apoptotic cell corpses. Dev Biol. 2017 Jun 22; 429 (2017 Jun 22; 1; 429):306-320. [Full Text/Abstract]
Kim S, Twigg SRF, Scanlon VA, Chandra A, Hansen TJ, Alsubait A, Fenwick AL, McGowan SJ, Lord H, Lester T, Sweeney E, Weber A, Cox H, Wilkie AOM, Golden A, Corsi AK. Localized TWIST1 and TWIST2 basic domain substitutions cause four distinct human diseases that can be modeled in Caenorhabditis elegans. Hum Mol Genet. 2017 Mar 27; 26 (2017 Mar 27; 26; 11):2118-2132. [Full Text/Abstract]
Jaramillo-Lambert A, Fabritius AS, Hansen TJ, Smith HE, Golden A. The Identification of a Novel Mutant Allele of topoisomerase II in Caenorhabditis elegans Reveals a Unique Role in Chromosome Segregation During Spermatogenesis. Genetics. 2016 Oct 5; 204 (2016 Oct 5; 204; 4):1407-1422. [Full Text/Abstract]
Smith HE, Fabritius AS, Jaramillo-Lambert A, Golden A. Mapping Challenging Mutations by Whole-Genome Sequencing. G3 (Bethesda). 2016 Mar 4; 6 (2016 Mar 4; 6; 5):1297-304. [Full Text/Abstract]
Stein KK, Golden A. The C. elegans eggshell. WormBook. 2015 Dec 30; 2018 (2015 Dec 30; 2018):1-36. [Full Text/Abstract]
Singaravelu G, Rahimi S, Krauchunas A, Rizvi A, Dharia S, Shakes D, Smith H, Golden A, Singson A. Forward Genetics Identifies a Requirement for the Izumo-like Immunoglobulin Superfamily spe-45 Gene in Caenorhabditis elegans Fertilization. Curr Biol. 2015 Dec 6; 25 (25; 2015 Dec 6; 24):3220-4. [Full Text/Abstract]
Choudhary V, Ojha N, Golden A, Prinz WA. A conserved family of proteins facilitates nascent lipid droplet budding from the ER. J Cell Biol. 2015 Oct 26; 211 (211; 2; 2015 Oct 26):261-71. [Full Text/Abstract]
Jaramillo-Lambert A, Fuchsman AS, Fabritius AS, Smith HE, Golden A. Rapid and Efficient Identification of Caenorhabditis elegans Legacy Mutations Using Hawaiian SNP-Based Mapping and Whole-Genome Sequencing. G3 (Bethesda). 2015 Mar 4; 5 (5; 2015 Mar 4):1007-19. [Full Text/Abstract]
Allen AK, Nesmith JE, Golden A. An RNAi-based suppressor screen identifies interactors of the Myt1 ortholog of Caenorhabditis elegans. G3 (Bethesda). 2014 Oct 8; 4 (2014 Oct 8; 4; 12):2329-43. [Full Text/Abstract]
O'Connell KF, Golden A. Confocal Imaging of the Microtubule Cytoskeleton in C. elegans Embryos and Germ Cells. Methods Mol Biol. 2014; 1075 (2014; 1075):257-72. [Full Text/Abstract]
Shakes DC, Allen AK, Albert KM, Golden A. emb-1 encodes the APC16 subunit of the Caenorhabditis elegans anaphase-promoting complex. Genetics. 2011 Oct; 189 (2; 189; 2011 Oct):549-60. [Full Text/Abstract]
Richie CT, Bembenek JN, Chestnut B, Furuta T, Schumacher JM, Wallenfang M, Golden A. Protein phosphatase 5 is a negative regulator of separase function during cortical granule exocytosis in C. elegans. J Cell Sci. 2011 Sep 1; 124 (124; Pt 17; 2011 Sep 1):2903-13. [Full Text/Abstract]
Stein KK, Nesmith JE, Ross BD, Golden A. Functional redundancy of paralogs of an anaphase promoting complex/cyclosome subunit in Caenorhabditis elegans meiosis. Genetics. 2010 Dec; 186 (186; 2010 Dec; 4):1285-93. [Full Text/Abstract]
Golden A, Liu J, Cohen-Fix O. Inactivation of the C. elegans lipin homolog leads to ER disorganization and to defects in the breakdown and reassembly of the nuclear envelope. J Cell Sci. 2009 Jun 15; 122 (Pt 12; 122; 2009 Jun 15):1970-8. [Full Text/Abstract]
Arur S, Ohmachi M, Nayak S, Hayes M, Miranda A, Hay A, Golden A, Schedl T. Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development. Proc Natl Acad Sci U S A. 2009 Mar 24; 106 (106; 2009 Mar 24; 12):4776-81. [Full Text/Abstract]
Bembenek JN, Richie CT, Squirrell JM, Campbell JM, Eliceiri KW, Poteryaev D, Spang A, Golden A, White JG. Cortical granule exocytosis in C. elegans is regulated by cell cycle components including separase. Development. 2007 Nov; 134 (2007 Nov; 134; 21):3837-48. [Full Text/Abstract]
Golden A, O'Connell KF. Silence is golden: combining RNAi and live cell imaging to study cell cycle regulatory genes during Caenorhabditis elegans development. Methods. 2007 Feb; 41 (2; 41; 2007 Feb):190-7. [Full Text/Abstract]
Stein KK, Davis ES, Hays T, Golden A. Components of the spindle assembly checkpoint regulate the anaphase-promoting complex during meiosis in Caenorhabditis elegans. Genetics. 2007 Jan; 175 (175; 2007 Jan; 1):107-23. [Full Text/Abstract]
Burrows AE, Sceurman BK, Kosinski ME, Richie CT, Sadler PL, Schumacher JM, Golden A. The C. elegans Myt1 ortholog is required for the proper timing of oocyte maturation. Development. 2006 Feb; 133 (2006 Feb; 133; 4):697-709. [Full Text/Abstract]
Richie CT, Golden A. Chromosome segregation: Aurora B gets Tousled. Curr Biol. 2005 May 24; 15 (15; 2005 May 24; 10):R379-82. [Full Text/Abstract]
Golden A, Cohen-Fix O. Getting (chromosomes) loaded--a new role for timeless. Dev Cell. 2003 Jul; 5 (2003 Jul; 5; 1):7-9. [Full Text/Abstract]
Shakes DC, Sadler PL, Schumacher JM, Abdolrasulnia M, Golden A. Developmental defects observed in hypomorphic anaphase-promoting complex mutants are linked to cell cycle abnormalities. Development. 2003 Apr; 130 (130; 8; 2003 Apr):1605-20. [Full Text/Abstract]
Ashcroft N, Golden A. CDC-25.1 regulates germline proliferation in Caenorhabditis elegans. Genesis. 2002 May; 33 (2002 May; 33; 1):1-7. [Full Text/Abstract]
Davis ES, Wille L, Chestnut BA, Sadler PL, Shakes DC, Golden A. Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I. Genetics. 2002 Feb; 160 (2; 160; 2002 Feb):805-13. [Full Text/Abstract]
Morton DG, Shakes DC, Nugent S, Dichoso D, Wang W, Golden A, Kemphues KJ. The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo. Dev Biol. 2002 Jan 1; 241 (2002 Jan 1; 241; 1):47-58. [Full Text/Abstract]