U.S. Department of Health and Human Services
Arthur Sherman

 Contact Info

Tel: 301-496-4325
Email: arthurs@mail.nih.gov

 Select Experience

  • Ph.D.New York University1986
  • M.S.New York University1983
  • B.A.Cornell University1973

 Related Links

  • Cell Biology/Cell Signaling
  • Computational Biology/Bioinformatics/Biostatistics/Mathematics
  • Neuroscience/Neurophysiology/Neurodevelopment


A selection of recent and significant publications can be viewed below.

McKenna JP, Ha J, Merrins MJ, Satin LS, Sherman A, Bertram R. Ca(2+) Effects on ATP Production and Consumption Have Regulatory Roles on Oscillatory Islet Activity. Biophys J. 2016 Feb 2; 110 (110; 3; 2016 Feb 2):733-42. [Full Text/Abstract]
Merrins MJ, Poudel C, McKenna JP, Ha J, Sherman A, Bertram R, Satin LS. Phase Analysis of Metabolic Oscillations and Membrane Potential in Pancreatic Islet β-Cells. Biophys J. 2016 Feb 2; 110 (110; 3; 2016 Feb 2):691-9. [Full Text/Abstract]
Watts M, Ha J, Kimchi O, Sherman A. Paracrine regulation of glucagon secretion: the β/α/δ model. Am J Physiol Endocrinol Metab. 2016 Feb 2; 310 (8; 310; 2016 Feb 2):E597-E611. [Full Text/Abstract]
Ha J, Satin LS, Sherman AS. A Mathematical Model of the Pathogenesis, Prevention, and Reversal of Type 2 Diabetes. Endocrinology. 2015 Dec 28; 157 (157; 2; 2015 Dec 28):624-635. [Full Text/Abstract]
Glynn E, Thompson B, Vadrevu S, Lu S, Kennedy RT, Ha J, Sherman A, Satin LS. Chronic Glucose Exposure Systematically Shifts the Oscillatory Threshold of Mouse Islets: Experimental Evidence for an Early Intrinsic Mechanism of Compensation for Hyperglycemia. Endocrinology. 2015 Dec 23; 157 (157; 2015 Dec 23; 2):611-623. [Full Text/Abstract]
Peercy BE, Sherman AS, Bertram R. Modeling of glucose-induced cAMP oscillations in pancreatic β cells: cAMP rocks when metabolism rolls. Biophys J. 2015 Jul 21; 109 (109; 2015 Jul 21; 2):439-49. [Full Text/Abstract]
Satin LS, Butler PC, Ha J, Sherman AS. Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes. Mol Aspects Med. 2015 Jan 28; 42 (42; 2015 Jan 28):61-77. [Full Text/Abstract]
Osinga HM, Sherman A, Tsaneva-Atanasova K. CROSS-CURRENTS BETWEEN BIOLOGY AND MATHEMATICS: THE CODIMENSION OF PSEUDO-PLATEAU BURSTING. Discrete Contin Dyn Syst Ser A. 2012 Aug; 32 (2012 Aug; 32; 8):2853-2877. [Full Text/Abstract]
Khadra A, Yan Z, Coddou C, Tomić M, Sherman A, Stojilkovic SS. Gating properties of the P2X2a and P2X2b receptor channels: experiments and mathematical modeling. J Gen Physiol. 2012 May; 139 (2012 May; 139; 5):333-48. [Full Text/Abstract]
Yan Z, Khadra A, Sherman A, Stojilkovic SS. Calcium-dependent block of P2X7 receptor channel function is allosteric. J Gen Physiol. 2011 Oct; 138 (138; 4; 2011 Oct):437-52. [Full Text/Abstract]
Sherman A. Dynamical systems theory in physiology. J Gen Physiol. 2011 Jul; 138 (138; 2011 Jul; 1):13-9. [Full Text/Abstract]
Matveev V, Bertram R, Sherman A. Calcium cooperativity of exocytosis as a measure of Ca²+ channel domain overlap. Brain Res. 2011 Jun 29; 1398 (2011 Jun 29; 1398):126-38. [Full Text/Abstract]
Khadra A, Pietropaolo M, Nepom GT, Sherman A. Investigating the role of T-cell avidity and killing efficacy in relation to type 1 diabetes prediction. PLoS One. 2011 May 10; 6 (6; 2011 May 10; 5):e14796. [Full Text/Abstract]
Yan Z, Khadra A, Li S, Tomic M, Sherman A, Stojilkovic SS. Experimental characterization and mathematical modeling of P2X7 receptor channel gating. J Neurosci. 2010 Oct 20; 30 (30; 2010 Oct 20; 42):14213-24. [Full Text/Abstract]
Sherman A. Lessons from models of pancreatic beta cells for engineering glucose-sensing cells. Math Biosci. 2010 Sep; 227 (2010 Sep; 227; 1):12-9. [Full Text/Abstract]
Peercy BE, Sherman AS. How pancreatic beta-cells discriminate long and short timescale cAMP signals. Biophys J. 2010 Jul 21; 99 (2010 Jul 21; 2; 99):398-406. [Full Text/Abstract]
Merrins MJ, Fendler B, Zhang M, Sherman A, Bertram R, Satin LS. Metabolic oscillations in pancreatic islets depend on the intracellular Ca2+ level but not Ca2+ oscillations. Biophys J. 2010 Jul 7; 99 (2010 Jul 7; 99; 1):76-84. [Full Text/Abstract]
Tsaneva-Atanasova K, Sherman A. Accounting for near-normal glucose sensitivity in Kir6.2[AAA] transgenic mice. Biophys J. 2009 Nov 4; 97 (97; 9; 2009 Nov 4):2409-18. [Full Text/Abstract]
Matveev V, Bertram R, Sherman A. Ca2+ current versus Ca2+ channel cooperativity of exocytosis. J Neurosci. 2009 Sep 30; 29 (39; 29; 2009 Sep 30):12196-209. [Full Text/Abstract]
Pedersen MG, Sherman A. Newcomer insulin secretory granules as a highly calcium-sensitive pool. Proc Natl Acad Sci U S A. 2009 May 5; 106 (106; 2009 May 5; 18):7432-6. [Full Text/Abstract]
Stern JV, Osinga HM, LeBeau A, Sherman A. Resetting behavior in a model of bursting in secretory pituitary cells: distinguishing plateaus from pseudo-plateaus. Bull Math Biol. 2008 Jan; 70 (2008 Jan; 70; 1):68-88. [Full Text/Abstract]
Bertram R, Sherman A, Satin LS. Metabolic and electrical oscillations: partners in controlling pulsatile insulin secretion. Am J Physiol Endocrinol Metab. 2007 Oct; 293 (2007 Oct; 293; 4):E890-900. [Full Text/Abstract]
Nunemaker CS, Bertram R, Sherman A, Tsaneva-Atanasova K, Daniel CR, Satin LS. Glucose modulates [Ca2+]i oscillations in pancreatic islets via ionic and glycolytic mechanisms. Biophys J. 2006 Sep 15; 91 (2006 Sep 15; 6; 91):2082-96. [Full Text/Abstract]
Nunemaker CS, Zhang M, Wasserman DH, McGuinness OP, Powers AC, Bertram R, Sherman A, Satin LS. Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo?. Diabetes. 2005 Dec; 54 (2005 Dec; 12; 54):3517-22. [Full Text/Abstract]
Pedersen MG, Bertram R, Sherman A. Intra- and inter-islet synchronization of metabolically driven insulin secretion. Biophys J. 2005 Jul; 89 (2005 Jul; 1; 89):107-19. [Full Text/Abstract]
Bertram R, Sherman A. Filtering of calcium transients by the endoplasmic reticulum in pancreatic beta-cells. Biophys J. 2004 Dec; 87 (6; 87; 2004 Dec):3775-85. [Full Text/Abstract]
Bertram R, Satin L, Zhang M, Smolen P, Sherman A. Calcium and glycolysis mediate multiple bursting modes in pancreatic islets. Biophys J. 2004 Nov; 87 (87; 2004 Nov; 5):3074-87. [Full Text/Abstract]
Bertram R, Sherman A. A calcium-based phantom bursting model for pancreatic islets. Bull Math Biol. 2004 Sep; 66 (66; 5; 2004 Sep):1313-44. [Full Text/Abstract]
Sedaghat AR, Sherman A, Quon MJ. A mathematical model of metabolic insulin signaling pathways. Am J Physiol Endocrinol Metab. 2002 Nov; 283 (2002 Nov; 283; 5):E1084-101. [Full Text/Abstract]
Bertram R, Sherman A, Stanley EF. Single-domain/bound calcium hypothesis of transmitter release and facilitation. J Neurophysiol. 1996 May; 75 (1996 May; 5; 75):1919-31. [Full Text/Abstract]
Bertram R, Butte MJ, Kiemel T, Sherman A. Topological and phenomenological classification of bursting oscillations. Bull Math Biol. 1995 May; 57 (1995 May; 3; 57):413-39. [Full Text/Abstract]