U.S. Department of Health and Human Services
Arthur Sherman

 Contact Info

Tel: 301-496-4325
Email: arthurs@mail.nih.gov

 Select Experience

  • Ph.D.New York University1986
  • M.S.New York University1983
  • B.A.Cornell University1973

 Related Links

  • Cell Biology/Cell Signaling
  • Computational Biology/Bioinformatics/Biostatistics/Mathematics
  • Neuroscience/Neurophysiology/Neurodevelopment


A selection of recent and significant publications can be viewed below.

Merrins MJ, Poudel C, McKenna JP, Ha J, Sherman A, Bertram R, Satin LS. Phase Analysis of Metabolic Oscillations and Membrane Potential in Pancreatic Islet β-Cells. Biophys J. 2016 Feb 2; 110 (110; 3; 2016 Feb 2):691-9. [Full Text/Abstract]
Watts M, Ha J, Kimchi O, Sherman A. Paracrine regulation of glucagon secretion: the β/α/δ model. Am J Physiol Endocrinol Metab. 2016 Feb 2; 310 (8; 310; 2016 Feb 2):E597-E611. [Full Text/Abstract]
McKenna JP, Ha J, Merrins MJ, Satin LS, Sherman A, Bertram R. Ca(2+) Effects on ATP Production and Consumption Have Regulatory Roles on Oscillatory Islet Activity. Biophys J. 2016 Feb 2; 110 (110; 3; 2016 Feb 2):733-42. [Full Text/Abstract]
Ha J, Satin LS, Sherman AS. A Mathematical Model of the Pathogenesis, Prevention, and Reversal of Type 2 Diabetes. Endocrinology. 2015 Dec 28; 157 (157; 2; 2015 Dec 28):624-635. [Full Text/Abstract]
Glynn E, Thompson B, Vadrevu S, Lu S, Kennedy RT, Ha J, Sherman A, Satin LS. Chronic Glucose Exposure Systematically Shifts the Oscillatory Threshold of Mouse Islets: Experimental Evidence for an Early Intrinsic Mechanism of Compensation for Hyperglycemia. Endocrinology. 2015 Dec 23; 157 (157; 2015 Dec 23; 2):611-623. [Full Text/Abstract]
Peercy BE, Sherman AS, Bertram R. Modeling of glucose-induced cAMP oscillations in pancreatic β cells: cAMP rocks when metabolism rolls. Biophys J. 2015 Jul 21; 109 (109; 2015 Jul 21; 2):439-49. [Full Text/Abstract]
Satin LS, Butler PC, Ha J, Sherman AS. Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes. Mol Aspects Med. 2015 Jan 28; 42 (42; 2015 Jan 28):61-77. [Full Text/Abstract]
Osinga HM, Sherman A, Tsaneva-Atanasova K. CROSS-CURRENTS BETWEEN BIOLOGY AND MATHEMATICS: THE CODIMENSION OF PSEUDO-PLATEAU BURSTING. Discrete Contin Dyn Syst Ser A. 2012 Aug; 32 (2012 Aug; 32; 8):2853-2877. [Full Text/Abstract]
Khadra A, Yan Z, Coddou C, Tomić M, Sherman A, Stojilkovic SS. Gating properties of the P2X2a and P2X2b receptor channels: experiments and mathematical modeling. J Gen Physiol. 2012 May; 139 (2012 May; 139; 5):333-48. [Full Text/Abstract]
Yan Z, Khadra A, Sherman A, Stojilkovic SS. Calcium-dependent block of P2X7 receptor channel function is allosteric. J Gen Physiol. 2011 Oct; 138 (138; 4; 2011 Oct):437-52. [Full Text/Abstract]
Sherman A. Dynamical systems theory in physiology. J Gen Physiol. 2011 Jul; 138 (138; 2011 Jul; 1):13-9. [Full Text/Abstract]
Matveev V, Bertram R, Sherman A. Calcium cooperativity of exocytosis as a measure of Ca²+ channel domain overlap. Brain Res. 2011 Jun 29; 1398 (2011 Jun 29; 1398):126-38. [Full Text/Abstract]
Khadra A, Pietropaolo M, Nepom GT, Sherman A. Investigating the role of T-cell avidity and killing efficacy in relation to type 1 diabetes prediction. PLoS One. 2011 May 10; 6 (6; 2011 May 10; 5):e14796. [Full Text/Abstract]
Yan Z, Khadra A, Li S, Tomic M, Sherman A, Stojilkovic SS. Experimental characterization and mathematical modeling of P2X7 receptor channel gating. J Neurosci. 2010 Oct 20; 30 (30; 2010 Oct 20; 42):14213-24. [Full Text/Abstract]
Sherman A. Lessons from models of pancreatic beta cells for engineering glucose-sensing cells. Math Biosci. 2010 Sep; 227 (2010 Sep; 227; 1):12-9. [Full Text/Abstract]
Peercy BE, Sherman AS. How pancreatic beta-cells discriminate long and short timescale cAMP signals. Biophys J. 2010 Jul 21; 99 (2010 Jul 21; 2; 99):398-406. [Full Text/Abstract]
Merrins MJ, Fendler B, Zhang M, Sherman A, Bertram R, Satin LS. Metabolic oscillations in pancreatic islets depend on the intracellular Ca2+ level but not Ca2+ oscillations. Biophys J. 2010 Jul 7; 99 (2010 Jul 7; 99; 1):76-84. [Full Text/Abstract]
Tsaneva-Atanasova K, Sherman A. Accounting for near-normal glucose sensitivity in Kir6.2[AAA] transgenic mice. Biophys J. 2009 Nov 4; 97 (97; 9; 2009 Nov 4):2409-18. [Full Text/Abstract]
Matveev V, Bertram R, Sherman A. Ca2+ current versus Ca2+ channel cooperativity of exocytosis. J Neurosci. 2009 Sep 30; 29 (39; 29; 2009 Sep 30):12196-209. [Full Text/Abstract]
Pedersen MG, Sherman A. Newcomer insulin secretory granules as a highly calcium-sensitive pool. Proc Natl Acad Sci U S A. 2009 May 5; 106 (106; 2009 May 5; 18):7432-6. [Full Text/Abstract]
Stern JV, Osinga HM, LeBeau A, Sherman A. Resetting behavior in a model of bursting in secretory pituitary cells: distinguishing plateaus from pseudo-plateaus. Bull Math Biol. 2008 Jan; 70 (2008 Jan; 70; 1):68-88. [Full Text/Abstract]
Bertram R, Sherman A, Satin LS. Metabolic and electrical oscillations: partners in controlling pulsatile insulin secretion. Am J Physiol Endocrinol Metab. 2007 Oct; 293 (2007 Oct; 293; 4):E890-900. [Full Text/Abstract]
Nunemaker CS, Bertram R, Sherman A, Tsaneva-Atanasova K, Daniel CR, Satin LS. Glucose modulates [Ca2+]i oscillations in pancreatic islets via ionic and glycolytic mechanisms. Biophys J. 2006 Sep 15; 91 (2006 Sep 15; 6; 91):2082-96. [Full Text/Abstract]
Nunemaker CS, Zhang M, Wasserman DH, McGuinness OP, Powers AC, Bertram R, Sherman A, Satin LS. Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo?. Diabetes. 2005 Dec; 54 (2005 Dec; 12; 54):3517-22. [Full Text/Abstract]
Pedersen MG, Bertram R, Sherman A. Intra- and inter-islet synchronization of metabolically driven insulin secretion. Biophys J. 2005 Jul; 89 (2005 Jul; 1; 89):107-19. [Full Text/Abstract]
Bertram R, Sherman A. Filtering of calcium transients by the endoplasmic reticulum in pancreatic beta-cells. Biophys J. 2004 Dec; 87 (6; 87; 2004 Dec):3775-85. [Full Text/Abstract]
Bertram R, Satin L, Zhang M, Smolen P, Sherman A. Calcium and glycolysis mediate multiple bursting modes in pancreatic islets. Biophys J. 2004 Nov; 87 (87; 2004 Nov; 5):3074-87. [Full Text/Abstract]
Bertram R, Sherman A. A calcium-based phantom bursting model for pancreatic islets. Bull Math Biol. 2004 Sep; 66 (66; 5; 2004 Sep):1313-44. [Full Text/Abstract]
Sedaghat AR, Sherman A, Quon MJ. A mathematical model of metabolic insulin signaling pathways. Am J Physiol Endocrinol Metab. 2002 Nov; 283 (2002 Nov; 283; 5):E1084-101. [Full Text/Abstract]
Bertram R, Sherman A, Stanley EF. Single-domain/bound calcium hypothesis of transmitter release and facilitation. J Neurophysiol. 1996 May; 75 (1996 May; 5; 75):1919-31. [Full Text/Abstract]
Bertram R, Butte MJ, Kiemel T, Sherman A. Topological and phenomenological classification of bursting oscillations. Bull Math Biol. 1995 May; 57 (1995 May; 3; 57):413-39. [Full Text/Abstract]