Genomes are massive databases that tell the body how to create cells, tissues, and organs. It is important to protect these databases and make sure that the genes within them keep their integrity. This is essential for fertility in animals and the survival of each species. Additionally, loss of genomic integrity has been observed in many diseases including cancer.
To protect these databases, the body uses various kinds of molecular guards. Our group studies a particular class of molecular guards that protect germ cells. Little is known about their elaborate surveillance system and defense strategies. We aim to generate valuable knowledge of how these databases are maintained.