U.S. Department of Health and Human Services
 

 Contact Info

 
Tel: 301-402-2616
Email: piknovab@mail.nih.gov
 

 Select Experience

 
  • NIH Staff ScientistPresent Molecular Medicine Branch, NIDDK2010
  • NIH Contractor Staff ScientistMolecular Medicine Branch, NIDDK2005–2010
  • Senior Research FellowNational Biomedical Electron Paramagnetic Resonance Center, Medical College of Wisconsin2003–2005
  • Postdoctoral FellowMolecular Medicine Department, Oregon Health & Science University1998–2003
  • Postdoctoral FellowBiochemistry Department, University of Illinois1996–1998
  • Postdoctoral FellowBiochemistry Department, University of Virginia1993–1996
  • Pre- and Postdoctoral FellowNational Centre for Scientific Research, Toulouse, France1991–1993
  • Ph.D.Comenius University, Bratislava, Slovakia1992
 

 Related Links

 

Barbora Piknova, Ph.D.

Staff Scientist, Molecular Biology and Genetics SectionMolecular Medicine Branch
Specialties
  • Biomedical Engineering/Biophysics/Physics
Research Summary/In Plain Language

Research Summary

Research Goal

The goal of our research is to provide a better understanding of vascular homeostasis regulation, especially in context of functional hyperemia.

Current Research

Our research examines the role of nitric oxide in vascular homeostasis, particularly in neurovascular coupling and hemodynamic response in the brain and in exercise-induced functional hyperemia in skeletal muscle.  In brain tissue, we focus on nitrite as an alternative source of nitric oxide and in the possibility of involvement of ascorbic acid in nitrite conversion to nitric oxide and importance of this process in neurovascular coupling.  The second area of interest includes nitric oxide metabolism and the balance of NOx compounds (nitrite, nitrate, and RSNO) in the vasculature and tissues that are associated with limited oxygen supply during ischemia.  We examine the possible use of NOx compounds in the prevention and treatment of reperfusion injury.  Recently, our focus shifted to mammalian tissue nitrate and nitrite reductases as well as nonenzymatic nitrite reduction into nitric oxide and their importance in normal physiology and as a possible source of nitric oxide for exercise-induced hyperemia.

Applying our Research

Some nitric oxide precursors are a part of normal healthy diet. Better understanding of their cycle and bio-transformation could affect prevention and treatment of vascular diseases.

Need for Further Study

More research is needed to understand the basic normal physiology of nitric oxide and its cycle in healthy humans.