The goal is to understand the mechanism through which GATA-1 controls erythropoiesis. GATA-1 exerts its effects by binding to specific DNA sites to activate genes and to participate in long-range chromatin interactions. It also participates in many protein-protein interactions. The downstream consequences of these are not yet completely understood.
My research is focused on the major erythroid transcription factor GATA-1 and the role it plays in DNA binding, regulating gene expression, and in controlling red blood cell development.