U.S. Department of Health and Human Services

 Contact Info

Tel: 301-594-8416
Email: cuilingl@mail.nih.gov

 Select Experience

  • Research AssociateContractor, Mammalian Genetics Section, GDDB, NIDDK, NIH2004-2006
  • BIO-TRAC training course: Transgenic Technology: Method and ApplicationFAES Graduate School at NIH2000
  • Research FellowGDDB, NIDDK, NIH1998-2004
  • Visiting FellowLaboratory of Biochemistry and Metabolism, NIDDK, NIH1996-1998
  • CertificateShanghai College of Traditional Chinese Medicine1993
  • Research AssistantSchool of Pharmacy, Medical University1992-1994
  • B.S.Shanghai Medical University, School of Pharmacy1992

 Related Links


Cuiling Li, Ph.D.

Biologist, Office of the Chief, Genetics of Development and Disease Branch
Biologist, Mouse CRISPR/Cas9 Genome Editing Facility
  • Cancer Biology
  • Cell Biology/Cell Signaling
  • Developmental Biology
  • Genetics/Genomics
  • Molecular Biology/Biochemistry
  • Stem Cells/Induced Pluripotent Stem Cells
Research Summary/In Plain Language

Research in Plain Language

Mice, humans, and most mammals—including dogs, cats, rabbits, monkeys, and apes—have roughly the same number of nucleotides in their genomes:  about 3 billion base pairs.  This comparable DNA content implies that all mammals contain more or less the same number of genes.  Inherited human diseases can be caused by a single alteration in one DNA molecule, leading to inheritance of sickle cell disease, cystic fibrosis, breast cancer, and many other diseases.

Because mouse and humans share about 85 percent of the same genes, we can idendify the gene in a mouse model, modify it (or create mutations), then transfer that mutation from generation to generation of study mice.  By targeting these modified genes in mouse models, scientists can study human diseases safely and learn how to treat or prevent certain illnesses.