U.S. Department of Health and Human Services

 Contact Info

Tel: 301-496-6370
Email: cuiyingx@mail.nih.gov

 Select Experience

  • Staff ScientistNIH2011-present
  • ContractorAnimal Biologist, NIH2011
  • Research FellowNIH2009-2010
  • Postdoctoral fellowNIH2004-2008
  • Associate ProfessorWest China Center of Medical Sciences, Sichuan University, Chengdu, Sichuan, China2003
  • Lecturer, Associate ProfessorWest China University of Medical Sciences1995-2001
  • Visiting ScholarNijmegen University1994-1995
  • Ph.D.Sichuan University2003
  • Visiting Ph.D. StudentWeizmann Institute of Science2001-2002
  • Master of MedicineWest China Center of Medical Sciences, Sichuan University, Chengdu, Sichuan, China1989
  • M.D.Luzhou Medical College, Luzhou, Sichuan, China1983

 Related Links


Cuiying Xiao, M.D., Ph.D.

Staff Scientist, Energy Homeostasis SectionDiabetes, Endocrinology, and Obesity Branch
  • Genetics/Genomics
  • Molecular Biology/Biochemistry


A selection of recent and significant publications can be viewed below.

Xiao C, Goldgof M, Gavrilova O, Reitman ML. Anti-obesity and metabolic efficacy of the β3-adrenergic agonist, CL316243, in mice at thermoneutrality compared to 22°C. Obesity (Silver Spring). 2015 Jun 5; 23 (2015 Jun 5; 23; 7):1450-1459. [Full Text/Abstract]
Abreu-Vieira G, Xiao C, Gavrilova O, Reitman ML. Integration of body temperature into the analysis of energy expenditure in the mouse. Mol Metab. 2015 Jun; 4 (6; 4; 2015 Jun):461-70. [Full Text/Abstract]
Lateef DM, Xiao C, Reitman ML. Search for an Endogenous Bombesin-Like Receptor 3 (BRS-3) Ligand Using Parabiotic Mice. PLoS One. 2015 Nov 12; 10 (2015 Nov 12; 10; 11):e0142637. [Full Text/Abstract]
Vassilopoulos A, Xiao C, Chisholm C, Chen W, Xu X, Lahusen TJ, Bewley C, Deng CX. Synergistic Therapeutic Effect of Cisplatin and Phosphatidylinositol 3-Kinase (PI3K) Inhibitors in Cancer Growth and Metastasis of Brca1 Mutant Tumors. J Biol Chem. 2014 Jul 8; 289 (35; 289; 2014 Jul 8):24202-14. [Full Text/Abstract]
Lute B, Jou W, Lateef DM, Goldgof M, Xiao C, Piñol RA, Kravitz AV, Miller NR, Huang YG, Girardet C, Butler AA, Gavrilova O, Reitman ML. Biphasic effect of melanocortin agonists on metabolic rate and body temperature. Cell Metab. 2014 Aug 5; 20 (20; 2014 Aug 5; 2):333-45. [Full Text/Abstract]
Masri S, Rigor P, Cervantes M, Ceglia N, Sebastian C, Xiao C, Roqueta-Rivera M, Deng C, Osborne TF, Mostoslavsky R, Baldi P, Sassone-Corsi P. Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism. Cell. 2014 Jul 31; 158 (158; 3; 2014 Jul 31):659-72. [Full Text/Abstract]
Goldgof M, Xiao C, Chanturiya T, Jou W, Gavrilova O, Reitman ML. The Chemical Uncoupler 2,4-Dinitrophenol (DNP) Protects Against Diet-induced Obesity and Improves Energy Homeostasis in Mice at Thermoneutrality. J Biol Chem. 2014 Jul 11; 289 (28; 2014 Jul 11; 289):19341-50. [Full Text/Abstract]
Lateef DM, Abreu-Vieira G, Xiao C, Reitman ML. Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3. Am J Physiol Endocrinol Metab. 2014 Mar; 306 (2014 Mar; 6; 306):E681-7. [Full Text/Abstract]
Ravussin Y, Xiao C, Gavrilova O, Reitman ML. Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice. PLoS One. 2014 Jan 17; 9 (2014 Jan 17; 9; 1):e85876. [Full Text/Abstract]
Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, Li YH, Wang X, Laurent G, German NJ, Xu X, Li C, Wang RH, Lee J, Csibi A, Cerione R, Blenis J, Clish CB, Kimmelman A, Deng CX, Haigis MC. SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell. 2013 Apr 15; 23 (23; 4; 2013 Apr 15):450-63. [Full Text/Abstract]
Xiao C, Wang RH, Lahusen TJ, Park O, Bertola A, Maruyama T, Reynolds D, Chen Q, Xu X, Young HA, Chen WJ, Gao B, Deng CX. Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J Biol Chem. 2012 Dec 7; 287 (50; 287; 2012 Dec 7):41903-13. [Full Text/Abstract]
Lee MH, Lahusen T, Wang RH, Xiao C, Xu X, Hwang YS, He WW, Shi Y, Deng CX. Yin Yang 1 positively regulates BRCA1 and inhibits mammary cancer formation. Oncogene. 2012 Jan 5; 31 (1; 31; 2012 Jan 5):116-27. [Full Text/Abstract]
Wang RH, Kim HS, Xiao C, Xu X, Gavrilova O, Deng CX. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J Clin Invest. 2011 Nov; 121 (2011 Nov; 121; 11):4477-90. [Full Text/Abstract]
Xiao C, Kim HS, Lahusen T, Wang RH, Xu X, Gavrilova O, Jou W, Gius D, Deng CX. SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J Biol Chem. 2010 Nov 19; 285 (285; 2010 Nov 19; 47):36776-84. [Full Text/Abstract]
Shukla V, Coumoul X, Lahusen T, Wang RH, Xu X, Vassilopoulos A, Xiao C, Lee MH, Man YG, Ouchi M, Ouchi T, Deng CX. BRCA1 affects global DNA methylation through regulation of DNMT1. Cell Res. 2010 Nov; 20 (2010 Nov; 20; 11):1201-15. [Full Text/Abstract]
Kim HS, Xiao C, Wang RH, Lahusen T, Xu X, Vassilopoulos A, Vazquez-Ortiz G, Jeong WI, Park O, Ki SH, Gao B, Deng CX. Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab. 2010 Sep 8; 12 (12; 3; 2010 Sep 8):224-36. [Full Text/Abstract]
Wang RH, Zheng Y, Kim HS, Xu X, Cao L, Luhasen T, Lee MH, Xiao C, Vassilopoulos A, Chen W, Gardner K, Man YG, Hung MC, Finkel T, Deng CX. Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol Cell. 2008 Oct 10; 32 (32; 2008 Oct 10; 1):11-20. [Full Text/Abstract]
Wang RH, Sengupta K, Li C, Kim HS, Cao L, Xiao C, Kim S, Xu X, Zheng Y, Chilton B, Jia R, Zheng ZM, Appella E, Wang XW, Ried T, Deng CX. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell. 2008 Oct 7; 14 (14; 4; 2008 Oct 7):312-23. [Full Text/Abstract]
Li W, Xiao C, Vonderhaar BK, Deng CX. A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation. Oncogene. 2007 Nov 8; 26 (2007 Nov 8; 26; 51):7204-12. [Full Text/Abstract]
Xiao C, Sharp JA, Kawahara M, Davalos AR, Difilippantonio MJ, Hu Y, Li W, Cao L, Buetow K, Ried T, Chadwick BP, Deng CX, Panning B. The XIST noncoding RNA functions independently of BRCA1 in X inactivation. Cell. 2007 Mar 9; 128 (2007 Mar 9; 128; 5):977-89. [Full Text/Abstract]
Shukla V, Coumoul X, Cao L, Wang RH, Xiao C, Xu X, Andò S, Yakar S, Leroith D, Deng C. Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members. Cancer Res. 2006 Jul 15; 66 (66; 14; 2006 Jul 15):7151-7. [Full Text/Abstract]
Xu X, Kobayashi S, Qiao W, Li C, Xiao C, Radaeva S, Stiles B, Wang RH, Ohara N, Yoshino T, LeRoith D, Torbenson MS, Gores GJ, Wu H, Gao B, Deng CX. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest. 2006 Jul; 116 (7; 116; 2006 Jul):1843-52. [Full Text/Abstract]
Cao L, Kim S, Xiao C, Wang RH, Coumoul X, Wang X, Li WM, Xu XL, De Soto JA, Takai H, Mai S, Elledge SJ, Motoyama N, Deng CX. ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. EMBO J. 2006 May 17; 25 (25; 2006 May 17; 10):2167-77. [Full Text/Abstract]
Wang RH, Li C, Xu X, Zheng Y, Xiao C, Zerfas P, Cooperman S, Eckhaus M, Rouault T, Mishra L, Deng CX. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2005 Dec; 2 (6; 2; 2005 Dec):399-409. [Full Text/Abstract]