U.S. Department of Health and Human Services
Daniel Appella

 Contact Info

Tel: 301-451-1052
Email: appellad@niddk.nih.gov

 Select Experience

  • Assistant ProfessorNorthwestern University2001-2004
  • Postdoctoral FellowMassachusetts Institute of Technology1998 – 2001
  • Ph.D.University of Wisconsin-Madison1998

 Related Links

  • Chemistry/Chemical Biology


Patents, materials, and other research resources appear below. Some resources may be available for use through Material Transfer Agreements (MTAs) or licensing agreements.

Resource Name Description
PNA-Detection of Pathogens (U.S. Patent Number 13/592,490)

The laboratory of Daniel Appella, PhD. has developed a prototype HIV testing kit that employs a peptide nucleic acid probe to capture HIV RNA recovered from patient blood.  The probe targets a highly conserved segment of the Gag sequence.   Initial…

Programmable self-assembled nanostructures based on sidechain-modified pna for the multivalent display of ligands (U.S. Patent Number EP 2569328 A2)

The invention concerns compositions comprising strands of polynucleotide and strands of PNA, each PNA strand comprising:

  • (i) from 2 to 50 nucleobase subunits and
  • (ii) one or more gamma substituents.

The PNA strands are complementary to at least a…

Anti-HIV Acylthiol & Thioether prodrugs (U.S. Patent Number 12/414,321)
These inventions provide the compositions, pharmaceutical carrier, and usages of the new Acylthiols (E-329-2000 family) and Thioether pro-drug (E-177-2010 family) compounds in treatment of retroviral infections such as HIV. These compounds target the…
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Clinical Trials

Open studies conducted by NIDDK Principal Investigators appear below that are currently recruiting, not yet recruiting, or available for expanded access.

Study Title
There are no associated clinical trials.
Search for more clinical trials at ClinicalTrials.gov